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Factors Associated with Macular Staphyloma Area on Ultra-widefield Fundus Images

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초록

Purpose: To assess the feasibility of applying ultra-widefield fundus (UWF) images for macular staphyloma area (MSA) measurementand investigate the associated factors with MSA. Methods: This is a retrospective study. MSA was measured by UWF imaging. Central foveal thickness, subfoveal choroidalthickness, subfoveal scleral thickness were measured on spectral domain optical coherence tomography. Intraclass correlationcoefficients of MSA measurement would be evaluated. Multiple linear regression analysis was used to analyze the associatedfactors with MSA. Results: In total, 135 eyes of 92 patients were enrolled. The mean age was 64.73 ± 10.84 years. Mean MSA on UWF imagewas 279.67 ± 71.70 mm2. Intraclass correlation coefficients of MSA measurement was 0.965 (95% confidence interval [CI], 0.946to 0.977; p < 0.001). In the multiple linear regression analysis, after adjusting for subfoveal choroidal thickness, best-correctedvisual acuity, central foveal thickness, and subfoveal scleral thickness, the factors independently related to MSA were axiallength (β = 8.352; 95% CI, 3.306 to 13.398; p = 0.001), sex (β = -26.673; 95% CI, -51.759 to -1.586; p = 0.037), age (β = 1.184;95% CI, 0.020 to 2.348; p = 0.046). Conclusions: It is feasible to measure MSA on UWF image. Female, longer axial length, and older age may indicate largerMSA.

Abstract

Purpose: To assess the feasibility of applying ultra-widefield fundus (UWF) images for macular staphyloma area (MSA) measurementand investigate the associated factors with MSA. Methods: This is a retrospective study. MSA was measured by UWF imaging. Central foveal thickness, subfoveal choroidalthickness, subfoveal scleral thickness were measured on spectral domain optical coherence tomography. Intraclass correlationcoefficients of MSA measurement would be evaluated. Multiple linear regression analysis was used to analyze the associatedfactors with MSA. Results: In total, 135 eyes of 92 patients were enrolled. The mean age was 64.73 ± 10.84 years. Mean MSA on UWF imagewas 279.67 ± 71.70 mm2. Intraclass correlation coefficients of MSA measurement was 0.965 (95% confidence interval [CI], 0.946to 0.977; p < 0.001). In the multiple linear regression analysis, after adjusting for subfoveal choroidal thickness, best-correctedvisual acuity, central foveal thickness, and subfoveal scleral thickness, the factors independently related to MSA were axiallength (β = 8.352; 95% CI, 3.306 to 13.398; p = 0.001), sex (β = -26.673; 95% CI, -51.759 to -1.586; p = 0.037), age (β = 1.184;95% CI, 0.020 to 2.348; p = 0.046). Conclusions: It is feasible to measure MSA on UWF image. Female, longer axial length, and older age may indicate largerMSA.

참고문헌 (40)

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