A Case of Therapy of Aerosolized Ribavirin in a Leukemia Infant with RSV Infection
0
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Respiratory syncytial virus (RSV) is the major cause of lower respiratory tract infection in infants. Life-threatening RSV infection is often reported in young children and immunocompromised hosts. Since there is no report on ribavirin therapy for RSV pneumonia in pediatric cancer patients in Korea, we report one case of RSV pneumonia that developed in an infant with acute lymphoblastic leukemia (ALL). Despite administration of oral ribavirin and intravenous immunoglobulin,the patient’s respiratory distress worsened and admission to an intensive care unit was necessary. Chest x-ray showed multifocal consolidation, pneumothorax, and pneumomediastinum. Treatment with aerosolized ribavirin led to significant clinical improvement. The role of aerosolized ribavirin is still controversial, but it might have a therapeutic potential for severe RSV pneumonia in children with leukemia.
Abstract
Respiratory syncytial virus (RSV) is the major cause of lower respiratory tract infection in infants. Life-threatening RSV infection is often reported in young children and immunocompromised hosts. Since there is no report on ribavirin therapy for RSV pneumonia in pediatric cancer patients in Korea, we report one case of RSV pneumonia that developed in an infant with acute lymphoblastic leukemia (ALL). Despite administration of oral ribavirin and intravenous immunoglobulin,the patient’s respiratory distress worsened and admission to an intensive care unit was necessary. Chest x-ray showed multifocal consolidation, pneumothorax, and pneumomediastinum. Treatment with aerosolized ribavirin led to significant clinical improvement. The role of aerosolized ribavirin is still controversial, but it might have a therapeutic potential for severe RSV pneumonia in children with leukemia.
참고문헌 (19)
- Wright M, "Respiratory syncytial virus prevention and therapy: past, present, and future", Pediatr Pulmonol, 46, pp.324~347 (2011)
- Law BJ, "An update on respiratory syncytial virus epidemiology: a developed country perspective", Respir Med, 96, pp.1~7 (2002)
- Welliver RC, "Review of epidemiology and clinical risk factors for severe respiratory syncytial virus (RSV) infection", J Pediatr, 143, pp.112~117 (2003)
- De Pauw B, "Revised definitions of invasive fungal disease from the European Organization for Research and Treatment of Cancer", Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and Infectious Diseases Mycoses Study Group (EORTC, Clin Infect Dis, pp.2008, 46[DOI]
- Harrington RD, "An outbreak of respiratory syncytial virus in a bone marrow transplant center", J Infect Dis, 165, pp.987~993 (1992)
- Torres HA, "Characteristics and outcome of respiratory syncytial virus infection in patients with leukemia", Haematologica, 92, pp.1216~1223 (2007)
- Hall CB, "Respiratory syncytial viral infection in children with compromised immune function", N Engl J Med, 315, pp.77~81 (1986)
- El Saleeby CM, "Risk factors for severe respiratory syncytial virus disease in children with cancer: the importance of lymphopenia and young age", Pediatrics, 121, pp.235~243 (2008)
- Raboni SM, "Respiratory tract viral infections in bone marrow transplant patients", Transplantation, 76, pp.142~146 (2003)
- Groothuis JR, "Early ribavirin treatment of respiratory syncytial viral infection in high-risk children", J Pediatr, 117, pp.792~798 (1990)
- Hall CB, "Aerosolized ribavirin treatment of infants with respiratory syncytial viral infection. A randomized double-blind study", N Engl J Med, 308, pp.1443~1447 (1983)
- Shults RA, "Health care worker exposure to aerosolized ribavirin: biological and air monitoring", J Occup Environ Med, 38, pp.257~263 (1996)
- Anak S, "Respiratory syncytial virus infection outbreak among pediatric patients with oncologic diseases and", or BMT, 2010, pp.45, 307~311
- Raza K, "Successful outcome of human metapneumovirus (hMPV) pneumonia in a lung transplant recipient treated with intravenous ribavirin", J Heart Lung Transplant, 26, pp.862~864 (2007)
- Sparrelid E, "Ribavirin therapy in bone marrow transplant recipients with viral respiratory tract infections", Bone Marrow Transplant, 19, pp.905~908 (1997)
- Hasejima N, "Invasive pulmonary aspergillosis associated with influenza B", Respirology, 10, pp.116~119 (2005)
- Alba D, "Invasive pulmonary aspergillosis associated with influenza virus", An Med Interna, 13, pp.34~36 (1996)
- Marr KA, "Invasive aspergillosis in allogeneic stem cell transplant recipients: changes in epidemiology and risk factors", Blood, 100, pp.4358~4366 (2002)
- Martino R, "Lower respiratory tract respiratory virus infections increase the risk of invasive aspergillosis after a reduced-intensity allogeneic hematopoietic SCT", Bone Marrow Transplant, 44, pp.749~756 (2009)