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Clinical Features of Respiratory Syncytial Virus Infection in Neonates: A Single Center Study

Gwang Cheon Jang|Shin Won Yoon|Sung Hui Chang
대한신생아학회 (THE KOREAN SOCIETY OF NEONATOLOGY)|2018.11|Neonatal medicine|제25권 제4호|pp. 144-152|DOI https://doi.org/10.5385/nm.2018.25.4.144

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NewbornRespiratory syncytial virusesPalivizumabPost-natal care center

초록

Purpose: The aim of this study was to investigate the clinical characteristics of Respiratory syncytial virus (RSV) infection during the neonatal period to provide information that is useful in clinical practice and suggest extension of the palivizumab administration. Methods: Neonates admitted to the National Health Insurance Service Ilsan Hospital neonatal intensive care unit due to respiratory symptoms and for whom multiplex reverse transcription-polymerase chain reaction and multiplex real time-polymerase chain reaction tests were performed between October 2011 and May 2016 were included in this study. Medical records were retrospectively reviewed, and data was collected for 156 neonates. Results: Among the 156 neonates, RSV was detected in 114 (73.1%), non-RSV in 25 (16%), and no virus in 17 (10.9%). The majority were full term infants (92.4%) and peak incidence of RSV infection was in January. Post-natal care center infection was more common in the RSV group (46.6%) than that in the other virus groups (24%, P= 0.0243). Clinical symptoms were severe in the RSV group in contrast to that in the non-RSV or others groups. The RSV group frequently needed oxygen therapy (P= 0.0001) and the duration of hospital stays were longer (P=0.0001). Conclusion: RSV is a significant cause of respiratory infection in neonates and the severity is higher in contrast to that with other viral causes of infection. Infants in post-natal care centers have a high-risk of developing RSV infections; therefore, palivizumab administration may be considered in this group to prevent hospitalization and reduce the duration of hospital stay.

Abstract

Purpose: The aim of this study was to investigate the clinical characteristics of Respiratory syncytial virus (RSV) infection during the neonatal period to provide information that is useful in clinical practice and suggest extension of the palivizumab administration. Methods: Neonates admitted to the National Health Insurance Service Ilsan Hospital neonatal intensive care unit due to respiratory symptoms and for whom multiplex reverse transcription-polymerase chain reaction and multiplex real time-polymerase chain reaction tests were performed between October 2011 and May 2016 were included in this study. Medical records were retrospectively reviewed, and data was collected for 156 neonates. Results: Among the 156 neonates, RSV was detected in 114 (73.1%), non-RSV in 25 (16%), and no virus in 17 (10.9%). The majority were full term infants (92.4%) and peak incidence of RSV infection was in January. Post-natal care center infection was more common in the RSV group (46.6%) than that in the other virus groups (24%, P= 0.0243). Clinical symptoms were severe in the RSV group in contrast to that in the non-RSV or others groups. The RSV group frequently needed oxygen therapy (P= 0.0001) and the duration of hospital stays were longer (P=0.0001). Conclusion: RSV is a significant cause of respiratory infection in neonates and the severity is higher in contrast to that with other viral causes of infection. Infants in post-natal care centers have a high-risk of developing RSV infections; therefore, palivizumab administration may be considered in this group to prevent hospitalization and reduce the duration of hospital stay.

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관련 논문AI추천

신생아집중치료실에서의 급성 호흡기 감염-바이러스의 검출 및 respiratory syncytial virus 감염의 임상적 특징차한, 박선희, 선용한, 손동우, 심소연, 은병욱, 전인상, 조혜정대한신생아학회 · Neonatal medicine2009 · 제16권 제2호Clinical Characteristics of Acute Respiratory Tract Infections in Full-Term Newborns without Risk FactorsByung Jin Song, Won Duck Kim, Woo Sun Song대한신생아학회 · Neonatal medicine2015 · 제22권 제1호기관지폐이형성증을 가진 미숙아 환아에서 하기도 호흡기감염의 임상 양상김세진, 이나현, 최희정대한 소아알레르기 호흡기학회 · Allergy Asthma & Respiratory Disease2017 · 제5권 제2호Respiratory syncytial virus로 인한 급성 하기도 감염 입원 환자에서 Palivizumab 예방요법 유무에 따른 비교 분석강은경, 김도현, 김희섭, 민성주, 선한수, 송정숙, 최장환대한소아감염학회 · Pediatric Infection and Vaccine2011 · 제18권 제2호미숙아에서 무호흡이 동반된 Respiratory Syncytial Virus에 의한 폐렴 1례마상혁, 이규만대한소아감염학회 · Pediatric Infection and Vaccine1999 · 제6권 제1호호흡기세포융합 바이러스 아형에 따른 영아기 폐렴 및 모세기관지염의 임상 양상: 2010.2012 일개 삼차병원의 경험김여향, 윤가현대한 소아알레르기 호흡기학회 · Allergy Asthma & Respiratory Disease2013 · 제1권 제1호

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