본문 바로가기
KERD
논문KCI 등재

12주간의 비타민D 섭취와 순환운동이 비타민D 결핍제2형 당뇨병 노인 여성의 골격근량에 미치는 영향

The Effects of 12-Weeks of Vitamin D Supplementation and Circuit Training on Skeletal Muscle Mass in Elderly Women with Type-2 Diabetes Mellitus and Vitamin D Deficiency

0

조회

0

다운로드

6

인용

0

참고문헌

키워드

주제분류체육

초록

이 연구에서는 12주간의 비타민D 섭취와 순환운동이 비타민D 결핍 제2형 당뇨병 노인 여성의 골격근량에 미치는 영향을 구명하고자 하였다. 아울러 이 변인들과 밀접한 관계가 있는 신체구성, 인슐린 저항성 및 비타민D에 대한 영향도 함께 구명하고자 하였다. 연구 대상자로 비타민D 결핍 제2형 당뇨병 노인 여성 48명을 통제집단, 비타민D 섭취집단, 순환운동집단, 복합처치집단으로 무선할당하였다. 비타민D는 12주간 매일 하루 1,200 IU 섭취하였으며, 순환운동프로그램은 주 3회 실시하였다. 사전검사와 사후검사에서 신체구성을 측정하였고, 혈액을 통해 25(OH)D, 공복혈당, 그리고 인슐린 농도를 분석하였다. 12주간의 비타민D 섭취와 순환운동 트레이닝 후 순환운동집단과 복합처치집단의 체지방률이 유의하게 감소하였고, 비타민D 섭취집단, 순환운동집단, 복합처치집단의 25(OH)D 수준이 유의하게 증가하였다. 또한 공복혈당, 인슐린, 그리고 HOMA-IR의 경우 모든 집단에서 유의한 차이가 나타나지 않았으며, 제지방량은 복합처치집단에서만 유의하게 증가하였다. 이상의 결과를 종합해보면, 12주간의 비타민D 섭취와 순환운동은 제지방량의 증가에 있어 단일처치보다 복합처치 시 긍정적인 영향을 주는 것으로 결론지을 수 있다.

Abstract

The objective of this study was to investigate the effects of 12-weeks of vitamin D supplementation and circuit training on skeletal muscle mass in elderly women with type 2 diabetes mellitus and vitamin D deficiency. Forty eight elderly women with type-2 diabetes mellitus and vitamin D deficiency were randomly assigned to control(n=10), vitamin D supplement(n=11), exercise(n=12), and vitamin D supplement+exercise(n=15) groups. Dependent variables were measured before and after the 12-week interventions. Major outcomes included body composition, fasting glucose, insulin, and 25(OH)D concentration. ASM(apeendicular skeletal muscle mass), SMI(skeletal muscle mass), and HOMA-IR (homeostasis model for insulin resistance) were calculated. Women assigned to the vitamin D supplement consumed 1,200 IU of vitamin D orally per week for 12 weeks. Women assigned to the exercise intervention performed a circuit training at an intensity of 60%~80% of HRmax with a frequency of 3 days per week for 12 weeks. Compared to control group, all groups had significant loss of body weight and increases in serum 25(OH)D after the 12-week intervention. ASM and SMI increased significantly in only vitamin D+exercise group. Regardless of treatments, no significant group differences were found in changed scores of fasting glucose, insulin, and HOMA-IR. In conclusion, vitamin D + exercise would improve the loss of ASM and SMI compared with vitamin D or exercise alone.

참고문헌 (66)

  1. 권영섭, "Brief review of muscle hypertrophy mechanism", 스포츠건강의학 학술지, 9(2), pp.13~20 (2007)
  2. 김상훈, "12주간의 순환운동이 노인비만여성의 비만, 체력 및 대사증후군 지표에 미치는 영향", 한국노년학, 29(3), pp.823~835 (2009), 한국노년학회
  3. 김인경, "비타민 D 섭취와 운동프로그램 적용이 여성 노인의 생리적 지표, 근육량 및 신체 기능에 미치는 영향", 박사, 간호과학과, pp.2012
  4. 대한당뇨학회, "Diabetes fact sheet in Korea 2012", ~ (2012)
  5. 대한비만학회, "Fact sheet", ~ (2010)
  6. 박상갑, "복합운동프로그램이 Sarcopenia 여성노인을 위한 건강체력과 항노화호르몬 및 근감소증예방에 미치는 영향", 한국사회체육학회지, 40(40), pp.435~442 (2010), 한국사회체육학회
  7. 소위영, "미용덤벨 운동이 노인의 근감소증 예방을 위한 신체조성, 체력 및 혈중지질에 미치는 영향", 한국노년학, 29(3), pp.837~850 (2009), 한국노년학회
  8. 오수일, "복합운동프로그램이 중년 여성의 신체구성, 건강관련체력 및 대사증후군 위험인자에 미치는 영향", 운동학 학술지, 15(3), pp.91~100 (2013), 대한운동학회
  9. 유민주, "단거리 육상선수와 일반여대생의 신체구성, 골밀도와 골밀도 관련 요인 분석", 한국여성체육학회지, 25(3), pp.121~134 (2011), 한국여성체육학회
  10. 정성림, "순환운동과 유산소운동이 비만 중년여성의 대사성증후군 위험인자 및 동맥경화 지수 변화에 미치는 영향", 한국체육과학회지, 18(1), pp.1019~1030 (2009), 한국체육과학회
  11. 최영미, "당뇨병환자에서 칼슘과 비타민 D 섭취가 인슐린저항성에 미치는 영향", Diabetes and Metabolism Journal, 33(4), pp.324~334 (2009), 대한당뇨병학회
  12. 홍상모, "Sarcopenia의 최신지견: 근감소증", 대한내과학회지, 83(4), pp.444~454 (2012), 대한내과학회[DOI]
  13. Baker, S., "Effects and clinical potential of very-low-calorie diets(VLCDs)in type 2 diabetes", Diabetes Research and Clinical Practice, 85(3), pp.235~242 (2009)
  14. Bassil, M. S., "Muscle protein anabolism in type 2 diabetes", Current Opinion in Clinical Nutrition & Metabolic Care, 16(1), pp.83~88 (2013)
  15. Baumgartner, R. N., "Epidemiology of sarcopenia among the elderly in New Mexico", American Journal of Epidemiology, 147(8), pp.755~763 (1998)
  16. Bischoff-Ferrari, H. A., "Estimation of optimal serum concentrations of 25-hydroxy vitamin D for multiple health outcomes", The American Journal of Clinical Nutrition, 84(1), pp.18~28 (2006)
  17. Borissova, A. M., "The effect of vitamin D3 on insulin secretion and peripheral insulin sensitivity in type 2diabetic patients", International Journal of Clinical Practice, 57(4), pp.258~261 (2003)
  18. Choi, H. S., "Vitamin D insufficiency in Korea—a greater threat to younger generation : the Korea National Health and Nutrition Examination Survey(KNHANES)2008", Journal of Clinical Endocrinology & Metabolism, 96(3), pp.643~651 (2011)
  19. Christ-Roberts, C. Y., "Exercise training increases glycogen synthase activity and GLUT4 expression but not insulin signaling in overweight nondiabetic and type 2 diabetic subjects", Metabolism, 53(9), pp.1233~1242 (2004)
  20. Colberg, S. R., "Exercise and Type 2 Diabetes The American College of Sports Medicine and the American Diabetes Association : joint position statement executive summary", Diabetes Care, 33(12), pp.2692~2696 (2010)
  21. Cuff, D. J., "Effective exercise modality to reduce insulin resistance in women with type 2 diabetes", Diabetes Care, 26(11), pp.2977~2982 (2003)
  22. Dalgård, C., "Vitamin D status in relation to glucose metabolism and type 2 diabetes in septuagenarians", Diabetes Care, 34(6), pp.1284~1288 (2011)
  23. Davidson, L. E., "Effects of exercise modality on insulin resistance and functional limitation in older adults : a randomized controlled trial", Archives of Internal Medicine, 169(2), pp.122~131 (2009)
  24. Delmonico, M. J., "Alternative definitions of sarcopenia, lower extremity performance, and functional impairment with aging in older men and women", Journal of the American Geriatrics Society, 55(5), pp.769~774 (2007)
  25. Doherty, T. J., "Invited review : aging and sarcopenia", Journal of Applied Physiology, 95(4), pp.1717~1727 (2003)
  26. Duncan, G. E., "Exercise training, without weight loss, increases insulin sensitivity and post heparin plasma lipase activity in previously sedentary adults", Diabetes Care, 26(3), pp.557~562 (2003)
  27. Fujita, S., "Aerobic exercise overcomes the age-related insulin resistance of muscle protein metabolism by improving endothelial function and Akt", mammalian target of rapamycin signaling, 2007, pp.56(6), 1615~1622
  28. George, P. S., "Effect of vitamin D supplementation on glycemic control and insulin resistance", Diabetic Medicine, 29(8), pp.142~150 (2012)
  29. Goodpaster, B. H., "Enhanced fat oxidation through physical activity is associated with improvements in insulin sensitivity in obesity", Diabetes, 52(9), pp.2191~2197 (2003)
  30. Holick, M. F., "Vitamin D : photobiology, metabolism, mechanism of action, and clinical applications. In : Favus M, ed. Primer on the metabolic bone diseases and disorders of mineral metabolism", American Society for Bone and Mineral Research, 5, pp.129~137 (2003)
  31. Holick, M. F., "Vitamin D deficiency", New England Journal of Medicine, 357(3), pp.266~281 (2007)
  32. Hurskainen, A. R., "Association of serum 25‐hydroxy vitamin D with type 2 diabetes and markers of insulin resistance in a general older population in Finland", Diabetes, 2012, pp.28(5), 418~423
  33. Iannuzzi-Sucich, M., "Prevalence of sarcopenia and predictors of skeletal muscle mass in healthy, older men and women", The Journals of Gerontology Series A : Biological Sciences and Medical Sciences, 57(12), pp.772~777 (2002)
  34. Ibañez, J., "Twice-weekly progressive resistance training decreases abdominal fat and improves insulin sensitivity in older men with type 2 diabetes", Diabetes Care, 28(3), pp.662~667 (2005)
  35. Kelley, G. A., "Effects of aerobic exercise on lipids and lipoproteins in adults with type 2diabetes : a meta-analysis of randomized-controlled trials", Public Health, 121(9), pp.643~655 (2007)
  36. 김경수, "Management of Type 2 Diabetes Mellitus in Older Adults", Diabetes and Metabolism Journal, 36(5), pp.336~344 (2012), 대한당뇨병학회[DOI]
  37. Kim, T. N., "Prevalence and determinant factors of sarcopenia in patients with type 2diabetes: the Korean Sarcopenic Obesity Study (KSOS)", Diabetes Care, 33(7), pp.1497~1499 (2010)
  38. Koopman, R., "Aging, exercise, and muscle protein metabolism", Journal of Applied Physiology, 106(6), pp.2040~2048 (2009)
  39. Krentz, A. J., "Insulin resistance : a risk marker for disease and disability in the older person", Diabetic Medicine, 30(5), pp.535~548 (2013)
  40. Landi, F., "Sarcopenia and Diabetes : Two Sides of the Same Coin", Journal of the American Medical Directors Association, 14(8), pp.540~541 (2013)
  41. Lee, J. H., "Vitamin D Deficiency; An Important, Common, and Easily Treatable Cardiovascular Risk Factor?", Journal of the American College of Cardiology, 52(24), pp.1949~1956 (2008)
  42. Additive association of vitamin D insufficiency and sarcopenia with low femoral bone mineral density in non-institutionalized elderly population:the Korea National Health and Nutrition Examination Surveys 2009-2010, "Lee, S. G.", Osteoporosis International, 1~11 (2013)
  43. Lim, S., "Vitamin D inadequacy is associated with significant coronary artery stenosis in a community-based elderly cohort : the Korean Longitudinal Study on Health and Aging", Journal of Clinical Endocrinology & Metabolism, 97(1), pp.169~178 (2012)
  44. Malabanan, A., "Redefining vitamin D insufficiency", The Lancet, 351(9105), pp.805~806 (1998)
  45. Marcus, R. L., "Comparison of combined aerobic and high-force eccentric resistance exercise with aerobic exercise only for people with type 2diabetes mellitus", Physical Therapy, 88(11), pp.1345~1354 (2008)
  46. Mason, C., "Influence of diet, exercise, and serum vitamin D on sarcopenia in postmenopausal women", Medicine and Science in Sports and Exercise, 45(4), pp.607~614 (2012)
  47. Mattila, C., "Serum 25-hydroxy vitamin D concentration and subsequent risk of type 2 diabetes", Diabetes Care, 30(10), pp.2569~2570 (2007)
  48. Meneilly, G. S., "Diabetes in elderly adults", The Journals of Gerontology Series A : Biological Sciences and Medical Sciences, 56(1), pp.5~13 (2001)
  49. Need, A. G., "Relationship between fasting serum glucose, age, body mass index and serum 25 hydroxy vitamin D in postmenopausal women", Clinical Endocrinology, 62(6), pp.738~741 (2005)
  50. Newman, A. B., "Sarcopenia : alternative definitions and associations with lower extremity function", Journal of the American Geriatrics Society, 51(11), pp.1602~1609 (2003)
  51. Pan, X. R., "Effects of diet and exercise in preventing NIDDM in people with impaired glucose tolerance : the Da Qing IGT and Diabetes Study", Diabetes Care, 20(4), pp.537~544 (1997)
  52. Park, S. W., "Excessive loss of skeletal muscle mass in older adults with type 2 diabetes", Diabetes Care, 32(11), pp.1993~1997 (2009)
  53. Patel, P., "Lack of effect of subtherapeutic vitamin D treatment on glycemic and lipid parameters in Type 2 diabetes : A pilot prospective randomized trial", Journal of Diabetes, 2(1), pp.36~40 (2010)
  54. Pittas, A. G., "The role of vitamin D and calcium in type 2 diabetes. A systematic review and meta-analysis", Journal of Clinical Endocrinology & Metabolism, 92(6), pp.2017~2029 (2007)
  55. Rejeski, W. J., "Lifestyle change and mobility in obese adults with type 2 diabetes", New England Journal of Medicine, 366(13), pp.1209~1217 (2012)
  56. Scragg, R., "Serum 25-hydroxy vitamin D, diabetes, and ethnicity in the Third National Health and Nutrition Examination Survey", Diabetes Care, 27(12), pp.2813~2818 (2004)
  57. Sigal, R. J., "Effects of aerobic training, resistance training, or both on glycemic control in type 2 diabetes; A randomized trial", Annals of Internal Medicine, 147(6), pp.357~369 (2007)
  58. Singh, M. A. F., "Insulin-like growth factor I in skeletal muscle after weight-lifting exercise in frail elders", American Journal of Physiology-Endocrinology and Metabolism, 277(1), pp.135~143 (1999)
  59. Snowling, N. J., "Effects of Different Modes of Exercise Training on Glucose Control and Risk Factors for Complications in Type 2 Diabetic Patients A meta-analysis", Diabetes Care, 29(11), pp.2518~2527 (2006)
  60. Verschueren, S. M., "The effects of whole‐body vibration training and vitamin D supplementation on muscle strength, muscle mass, and bone density in institutionalized elderly women : A 6‐month randomized, controlled trial", Journal of Bone and Mineral Research, 26(1), pp.42~49 (2011)
  61. Volpi, E., "Muscle tissue changes with aging", Current Opinion in Clinical Nutrition and Metabolic Care, 7(4), pp.405~410 (2004)
  62. Von Hurst, P. R., "Vitamin D supplementation reduces insulin resistance in South Asian women living in New Zealand who are insulin resistant and vitamin D deficient–a randomized, placebocontrolled trial", British Journal of Nutrition, 103(4), pp.549~ (2010)
  63. Wang, T. J., "Vitamin D deficiency and risk of cardiovascular disease", Circulation, 117(4), pp.503~511 (2008)
  64. Yarasheski, K. E., "Resistance exercise training increases mixed muscle protein synthesis rate in frail women and men≥ 76 yr old", American Journal of Physiology-Endocrinology and Metabolism, 277(1), pp.118~125 (1999)
  65. Zhou, Q. G., "1, 25-Dihydroxy vitamin D improved the free fatty‐acid‐induced insulin resistance in cultured C2C12 cells", Diabetes, 2008, pp.24(6), 459~464
  66. Ziambaras, K., "Reversible muscle weakness in patients with vitamin D deficiency", Western Journal of Medicine, 167(6), pp.435~439 (1997)

관련 논문AI추천

이 간행물의 다른 논문 (15건)