본문 바로가기
KERD
논문KCI 등재

Use of hypnotics and the risk of or mortality from heart disease: a meta-analysis of observational studies

2

조회

0

다운로드

0

인용

0

참고문헌

키워드

주제분류내과학

초록

Background/Aims: Some observational epidemiologic studies have reported conflicting results on the relationship between hypnotics use and the risk of developing and/or dying from heart disease. We investigated these associations using a meta-analysis of available literatures. Methods: We searched the databases PubMed and EMBASE, along with the bibliographies of relevant articles to find additional publications in February 2016. Results: Of 495 articles satisfying our initial criteria, two case-control studies and six cohort studies met our inclusion criteria and were included in the final analyses. Compared with never having used any kind of hypnotics, the odds ratio for overall use was 0.84 for risk of or mortality from heart disease (95% confidence interval, 0.79 to 0.89) in a random-effects meta-analysis of all eight studies. With respect to the geographical region, use of hypnotics was associated with a decreased risk or mortality of heart disease in Asia but not in Western countries. Among various types of sleep medications, zolpidem showed a decreased risk (–29%) of developing or dying from heart disease, but benzodiazepines were related with an increased risk (80%) of or mortality from heart disease. Conclusions: The current meta-analysis of observational epidemiological studies suggested an evidence of association between hypnotics use and a decreased risk of heart disease.

Abstract

Background/Aims: Some observational epidemiologic studies have reported conflicting results on the relationship between hypnotics use and the risk of developing and/or dying from heart disease. We investigated these associations using a meta-analysis of available literatures. Methods: We searched the databases PubMed and EMBASE, along with the bibliographies of relevant articles to find additional publications in February 2016. Results: Of 495 articles satisfying our initial criteria, two case-control studies and six cohort studies met our inclusion criteria and were included in the final analyses. Compared with never having used any kind of hypnotics, the odds ratio for overall use was 0.84 for risk of or mortality from heart disease (95% confidence interval, 0.79 to 0.89) in a random-effects meta-analysis of all eight studies. With respect to the geographical region, use of hypnotics was associated with a decreased risk or mortality of heart disease in Asia but not in Western countries. Among various types of sleep medications, zolpidem showed a decreased risk (–29%) of developing or dying from heart disease, but benzodiazepines were related with an increased risk (80%) of or mortality from heart disease. Conclusions: The current meta-analysis of observational epidemiological studies suggested an evidence of association between hypnotics use and a decreased risk of heart disease.

참고문헌 (40)

  1. Colten HR, "Sleep Disorders and Sleep Deprivation: An Unmet Public Health Problem" (2006), National Academies Press
  2. Nomura K, "Impact of insomnia on individual health dissatisfaction in Japan, South Korea, and Taiwan", Sleep, 28, pp.1328~1332 (2005)[DOI]
  3. Ancoli-Israel S, "Characteristics of insomnia in the United States: results of the 1991 National Sleep Foundation Survey. I", Sleep, 22(Suppl 2), pp.S347~S353 (1999)
  4. Morin CM, "Epidemiology of insomnia: prevalence, self-help treatments, consultations, and determinants of help-seeking behaviors", Sleep Med, 7, pp.123~130 (2006)[DOI]
  5. Mellinger GD, "Insomnia and its treatment: prevalence and correlates", Arch Gen Psychiatry, 42, pp.225~232 (1985)[DOI]
  6. Ohayon MM, "Psychotropic medication consumption patterns in the UK general population", J Clin Epidemiol, 51, pp.273~283 (1998)[DOI]
  7. Vermeeren A, "Residual effects of hypnotics: epidemiology and clinical implications", CNS Drugs, 18, pp.297~328 (2004)[DOI]
  8. Alvarenga JM, "Prevalence and sociodemographic characteristics associated with benzodiazepines use among community dwelling older adults: the Bambui Health and Aging Study (BHAS)", Rev Bras Psiquiatr, 30, pp.7~11 (2008)
  9. Sanna E, "Comparison of the effects of zaleplon, zolpidem, and triazolam at various GABA(A) receptor subtypes", Eur J Pharmacol, 451, pp.103~110 (2002)[DOI]
  10. Inagaki T, "Adverse reactions to zolpidem: case reports and a review of the literature", Prim Care Companion J Clin Psychiatry, 12, pp.e1~e8 (2010)
  11. Mailliet F, "Comparative effects of melatonin, zolpidem and diazepam on sleep, body temperature, blood pressure and heart rate measured by radiotelemetry in Wistar rats", Psychopharmacology (Berl), 156, pp.417~426 (2001)[DOI]
  12. Jehle J, "Mechanisms of zolpideminduced long QT syndrome: acute inhibition of recombinant hERG K(+) channels and action potential prolongation in human cardiomyocytes derived from induced pluripotent stem cells", Br J Pharmacol, 168, pp.1215~1229 (2013)[DOI]
  13. Kim DH, "Comparative anticancer effects of flavonoids and diazepam in cultured cancer cells", Biol Pharm Bull, 31, pp.255~259 (2008)[DOI]
  14. [URL]
  15. Mallon L, "Is usage of hypnotics associated with mortality?", Sleep Med, 10, pp.279~286 (2009)[DOI]
  16. Higgins JP, "Quantifying heterogeneity in a meta-analysis", Stat Med, 21, pp.1539~1558 (2002)[DOI]
  17. DerSimonian R, "Meta-analysis in clinical trials", Control Clin Trials, 7, pp.177~188 (1986)[DOI]
  18. Merlo J, "Increased risk of ischaemic heart disease mortality in elderly men using anxiolytics-hypnotics and analgesics: results of the 10-year follow-up of the prospective population study "Men born in 1914", Malmo, Sweden", Eur J Clin Pharmacol, 49, pp.261~265 (1996)[DOI]
  19. Zhou X, "Use of non-benzodiazepine hypnotics is associated with decreased risk of coronary artery disease", Intern Med, 51, pp.829~832 (2012)[DOI]
  20. Mallon L, "Sleep complaints predict coronary artery disease mortality in males: a 12-year follow-up study of a middle-aged Swedish population", J Intern Med, 251, pp.207~216 (2002)[DOI]
  21. Belleville G, "Mortality hazard associated with anxiolytic and hypnotic drug use in the National Population Health Survey", Can J Psychiatry, 55, pp.558~567 (2010)[DOI]
  22. Rod NH, "Psychosocial risk factors and heart failure hospitalization: a prospective cohort study", Am J Epidemiol, 174, pp.672~680 (2011)[DOI]
  23. Jaussent I, "Hypnotics and mortality in an elderly general population: a 12-year prospective study", BMC Med, 11, pp.212~ (2013)[DOI]
  24. Lan TY, "The use of hypnotics and mortality: a population-based retrospective cohort study", PLoS One, 10, pp.e0145271~ (2015)[DOI]
  25. Sofi F, "Insomnia and risk of cardiovascular disease: a meta-analysis", Eur J Prev Cardiol, 21, pp.57~64 (2014)[DOI]
  26. Vogelzangs N, "Cardiovascular disease in persons with depressive and anxiety disorders", J Affect Disord, 125, pp.241~248 (2010)[DOI]
  27. Roest AM, "Anxiety and risk of incident coronary heart disease: a meta-analysis", J Am Coll Cardiol, 56, pp.38~46 (2010)[DOI]
  28. Huang MP, "Effects of eszopiclone and zolpidem on sleep-wake behavior, anxiety-like behavior and contextual memory in rats", Behav Brain Res, 210, pp.54~66 (2010)[DOI]
  29. Price JF, "Risk factors and the sex differential in coronary artery disease", Epidemiology, 8, pp.584~591 (1997)[DOI]
  30. Gensini GF, "Classical risk factors and emerging elements in the risk profile for coronary artery disease", Eur Heart J, 19(Suppl A), pp.A53~A61 (1998)
  31. Virmani R, "Risk factors in the pathogenesis of coronary artery disease", Compr Ther, 24, pp.519~529 (1998)
  32. Lapane KL, "Is the use of psychotropic drugs associated with increased risk of ischemic heart disease?", Epidemiology, 6, pp.376~381 (1995)[DOI]
  33. Muzet A, "Benzodiazepine hypnotics increase heart rate during sleep", Sleep, 5, pp.256~261 (1982)[DOI]
  34. Hojer J, "Management of benzodiazepine overdose", CNS Drugs, 2, pp.7~17 (1994)[DOI]
  35. Ickowicz S, "Benzodiazepine use as an independent risk factor for HIV infection in a Canadian setting", Drug Alcohol Depend, 155, pp.190~194 (2015)[DOI]
  36. Kingery JR, "Short-term and long-term cardiovascular risk, metabolic syndrome and HIV in Tanzania", Heart, 102, pp.1200~1205 (2016)[DOI]
  37. Bach P, "Benzodiazepine use and hepatitis C seroconversion in a cohort of persons who inject drugs", Am J Public Health, 106, pp.1067~1072 (2016)[DOI]
  38. Domont F, "Chronic hepatitis C virus infection, a new cardiovascular risk factor?", Liver Int, 36, pp.621~627 (2016)[DOI]
  39. Bild DE, "Ethnic differences in coronary calcification: the Multi-Ethnic Study of Atherosclerosis (MESA)", Circulation, 111, pp.1313~1320 (2005)[DOI]
  40. deLemos AS, "Identification of genetic variants in endothelial lipase in persons with elevated high-density lipoprotein cholesterol", Circulation, 106, pp.1321~1326 (2002)[DOI]

관련 논문AI추천

이 간행물의 다른 논문 (23건)