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자궁경부암 조직에서 Clusterin의 발현양상

The Expression of Clusterin inCervical Cancer tissues

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초록

=목적: 정상자궁경부조직과 자궁경부암 조직에서의 clusterin 발현의 차이를 알아본다.연구 방법: 조직학적으로 규명된 15예의 정상 자궁경부 조직과 32예의 자궁경부암 조직에서 clusterin의 발현양상을 면역화학조직 염색법을 이용하여 정량화한 후 자궁경부암에서 clusterin의 발현이 유의한 차이를 보이는 지 통계학적으로 분석한다.결과: 정상 자궁경부조직에서 clusterin 발현은 평균 1.25이었고 자궁경부암 조직에서는 4.08로 clusterin은 정상 자궁경부조직에 비하여 자궁경부암 조직에서 높은 발현양상을 보였으며 민감도 89.7%와 특이도 94.4%로 Cut off 2.25를 취하였을 때 통계학적으로 유의한 차이를 보였다 (P<0.05).

참고문헌 (21)

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