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논문KCI 등재

사상자의 세포자기살해능이 자궁경부암세포에 미치는 영향

Effects of Apoptosis of Torilis Japonica on Cervical Cancer Cell

김기봉|박장경|안상현|권나연
대한한방부인과학회 (The Society Of Oriental Obstetrics & Gynecology)|2023.02|대한한방부인과학회지 (The Journal of Oriental Obstetrics ＆ Gynecology)|제36권 제1호|pp. 23-34|DOI 10.15204/jkobgy.2023.36.1.023

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키워드

ApoptosisCervical CancerTorilis JaponicaAnti-cancer Activity
주제분류한의학

초록

Objectives: This study was conducted to confirm the anticancer effect of Torilis Japonica (TJ) on cervical cancer and to determine whether the effect was apoptosis. Methods: In this study, the effect of TJ extract on toxicity, mitochondrial morphology, nuclear morphological changes, Extracellular signal-regulated kinase (ERK) and p38 mitogen-activated protein kinase (MAPK) pathway were investigated in HeLa cell, human cervical cancer cell. Results: The cytotoxicity, ratio of cells with nuclear changes to the total number of cells, and P38 phosphorylation increased in a concentration-dependent manner after administration of TJ extract. The length of mitochondria and ERK phosphorylation in HeLa cells decreased in a concentration-dependent manner after administration of TJ extract. Conclusions: TJ extract has an anticancer effect on cervical cancer cells, which is presumed to be due to apoptosis, and showed potential as a future cervical cancer treatment.

Abstract

Objectives: This study was conducted to confirm the anticancer effect of Torilis Japonica (TJ) on cervical cancer and to determine whether the effect was apoptosis. Methods: In this study, the effect of TJ extract on toxicity, mitochondrial morphology, nuclear morphological changes, Extracellular signal-regulated kinase (ERK) and p38 mitogen-activated protein kinase (MAPK) pathway were investigated in HeLa cell, human cervical cancer cell. Results: The cytotoxicity, ratio of cells with nuclear changes to the total number of cells, and P38 phosphorylation increased in a concentration-dependent manner after administration of TJ extract. The length of mitochondria and ERK phosphorylation in HeLa cells decreased in a concentration-dependent manner after administration of TJ extract. Conclusions: TJ extract has an anticancer effect on cervical cancer cells, which is presumed to be due to apoptosis, and showed potential as a future cervical cancer treatment.

참고문헌 (35)

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관련 논문AI추천

자궁경부암에 대한 천남성의 세포사멸 유도를 통한 항암 효과김수정, 이진무, 이창훈, 장준복, 황덕상대한한방부인과학회 · 대한한방부인과학회지2024 · 제37권 제4호濟川煎이 子宮頸部癌細胞(HeLa cell)에 미치는 影響김덕님, 김양호, 박경미, 유심근, 조한백대한한방부인과학회 · 대한한방부인과학회지2003 · 제16권 제2호자궁경부암세포에 대한 天花粉의 성장억제 및 세포사멸효과이현희, 임은미대한한방부인과학회 · 대한한방부인과학회지2005 · 제18권 제3호香稜丸이 子宮頸部癌細胞(HeLa Cell)의 apoptosis에 미치는 影響김송백, 박종규, 유심근, 조한백대한한방부인과학회 · 대한한방부인과학회지2004 · 제17권 제2호三稜이 子宮頸部癌細胞(HeLa cell)의 Apoptosis에 미치는 影響공복철, 김주연, 유심근, 최창민, 홍기철대한한방부인과학회 · 대한한방부인과학회지2005 · 제18권 제4호Orostachys japonicus induce caspase-dependent apoptosis in HeLa human cervical cancer cells김선희, 이동석한국영양학회 · Nutrition Research and Practice2025 · 제19권 제1호

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