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Prevalence of Atrial Fibrillation in Korean Population

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초록

Atrial fibrillation (AF) is the most common cardiac arrhythmia in clinical practice and has been a major public health problem. The prevalence of AF globally has been reported to range from 0.4% to 2% in the adult population; however, the prevalence widely varies depending on the study population. Although AF prevalence in Asian population is about 1% lower than that in European and North American population, the number of AF patients in Asia is rapidly increasing concomitant with the increased aging of the population. However, previous studies that reported AF epidemiology in the Korean population are limited. According to a recent report based on the national health claims database, prevalence of AF in 2015 was 0.7% in the entire Korean adult population and showed a continuous increase with population aging. Additionally, among patients with AF, mean CHA2DS2-VASc score was significantly increased and the number of high thromboembolic risk patients has increased over time. Although oral anticoagulation (OAC) prescription in AF patients increased from 35% to 51%, especially after introduction of non-vitamin K antagonist anticoagulants, a substantial proportion of Korean patients with AF still remain undertreated. In this review, we aimed to summarize temporal changes in the prevalence and incidence of AF and to evaluate the thromboembolic risk in patients with AF. In addition, we also discussed the utilization of OAC therapy in patients with AF in Korean population.

Abstract

Atrial fibrillation (AF) is the most common cardiac arrhythmia in clinical practice and has been a major public health problem. The prevalence of AF globally has been reported to range from 0.4% to 2% in the adult population; however, the prevalence widely varies depending on the study population. Although AF prevalence in Asian population is about 1% lower than that in European and North American population, the number of AF patients in Asia is rapidly increasing concomitant with the increased aging of the population. However, previous studies that reported AF epidemiology in the Korean population are limited. According to a recent report based on the national health claims database, prevalence of AF in 2015 was 0.7% in the entire Korean adult population and showed a continuous increase with population aging. Additionally, among patients with AF, mean CHA2DS2-VASc score was significantly increased and the number of high thromboembolic risk patients has increased over time. Although oral anticoagulation (OAC) prescription in AF patients increased from 35% to 51%, especially after introduction of non-vitamin K antagonist anticoagulants, a substantial proportion of Korean patients with AF still remain undertreated. In this review, we aimed to summarize temporal changes in the prevalence and incidence of AF and to evaluate the thromboembolic risk in patients with AF. In addition, we also discussed the utilization of OAC therapy in patients with AF in Korean population.

참고문헌 (49)

  1. Schnabel RB, "50-year trends in atrial fibrillation prevalence, incidence, risk factors, and mortality in the Framingham Heart Study: a cohort study", Lancet, 386, pp.154~162 (2015)
  2. Wolf PA, "Atrial fibrillation as an independent risk factor for stroke: the Framingham Study", Stroke, 22, pp.983~988 (1991)
  3. Colilla S, "Estimates of current and future incidence and prevalence of atrial fibrillation in the population", Am J Cardiol, 112, pp.1142~1147 (2013)
  4. Krijthe BP, "Projections on the number of individuals with atrial fibrillation in the European Union, from 2000 to 2060", Eur Heart J, 34, pp.2746~2751 (2013)
  5. Rahman F, "Global epidemiology of atrial fibrillation", Nat Rev Cardiol, 11, pp.639~654 (2014)
  6. Guo Y, "Prevalence, incidence, and lifetime risk of atrial fibrillation in China: new insights into the global burden of atrial fibrillation", Chest, 147, pp.109~119 (2015)
  7. Tse HF, "Stroke prevention in atrial fibrillation – an Asian stroke perspective", Heart Rhythm, 10, pp.1082~1088 (2013)
  8. Lee SR, "Trends in the incidence and prevalence of atrial fibrillation and estimated thromboembolic risk using the CHA2DS2-VASc score in the entire Korean population", Int J Cardiol, 236, pp.226~231 (2017)
  9. Chao TF, "Lifetime risks, projected numbers, and adverse outcomes in Asian patients with atrial fibrillation: A report from the Taiwan nationwide AF cohort study", Chest (2017)
  10. Lip GY, "Refining clinical risk stratification for predicting stroke and thromboembolism in atrial fibrillation using a novel risk factor-based approach: the euro heart survey on atrial fibrillation", Chest, 137, pp.263~272 (2010)
  11. European Heart Rhythm Association, "Guidelines for the management of atrial fibrillation: the Task Force for the Management of Atrial Fibrillation of the European Society of Cardiology (ESC)", Eur Heart J, 31, pp.2369~2429 (2010)
  12. Ruff CT, "Comparison of the efficacy and safety of new oral anticoagulants with warfarin in patients with atrial fibrillation: a meta-analysis of randomised trials", Lancet, 383, pp.955~962 (2014)
  13. Hart RG, "Meta-analysis: antithrombotic therapy to prevent stroke in patients who have nonvalvular atrial fibrillation", Ann Intern Med, 146, pp.857~867 (2007)
  14. Camm AJ, "Evolving antithrombotic treatment patterns for patients with newly diagnosed atrial fibrillation", Heart, 103, pp.307~314 (2017)
  15. Gadsbøll K, "Increased use of oral anticoagulants in patients with atrial fibrillation: temporal trends from 2005 to 2015 in Denmark", Eur Heart J, 38, pp.899~906 (2017)
  16. Huisman MV, "The Changing Landscape for Stroke Prevention in AF: Findings From the GLORIA-AF Registry Phase 2", J Am Coll Cardiol, 69, pp.777~785 (2017)
  17. Oh S, "Vitamin K antagonist control in patients with atrial fibrillation in Asia compared with other regions of the world: Real-world data from the GARFIELD-AF registry", Int J Cardiol, 223, pp.543~547 (2016)
  18. Lee SR, "Temporal trends of antithrombotic therapy for stroke prevention in Korean patients with non-valvular atrial fibrillation in the era of non-vitamin K antagonist oral anticoagulants: A nationwide population-based study", PLoS One, 12, pp.e0189495~ (2017)
  19. Go AS, "Prevalence of diagnosed atrial fibrillation in adults: national implications for rhythm management and stroke prevention: the AnTicoagulation and Risk Factors in Atrial Fibrillation (ATRIA) Study", JAMA, 285, pp.2370~2375 (2001)
  20. Jeong Joon Hoon, "Prevalence of and Risk Factors for Atrial Fibrillation in Korean Adults Older than 40 Years", Journal of Korean Medical Science, 20(1), pp.26~ (2005), 대한의학회
  21. 이광수, "Prevalence of Atrial Fibrillation in Middle-Aged People in Korea: The Korean Genome and Epidemiology Study", Korean Circulation Journal, 38(11), pp.601~605 (2008), 대한심장학회
  22. Mi Kyoung Son, "Incidence and Risk Factors for Atrial Fibrillation in Korea: the National Health Insurance Service Database (2002–2010)", Korean Circulation Journal, 46(4), pp.515~521 (2016), 대한심장학회
  23. 이한철, "The Trends of Atrial Fibrillation-Related Hospital Visit and Cost, Treatment Pattern and Mortality in Korea: 10-Year Nationwide Sample Cohort Data", Korean Circulation Journal, 47(1), pp.56~64 (2017), 대한심장학회
  24. Inoue H, "Prevalence of atrial fibrillation in the general population of Japan: an analysis based on periodic health examination", Int J Cardiol, 137, pp.102~107 (2009)
  25. Zhou Z, "An epidemiology study on the prevalence of atrial fibrillation in the Chinese population of mainland China", J Epidemiol, 18, pp.209~216 (2008)
  26. Kishore A, "Detection of atrial fibrillation after ischemic stroke or transient ischemic attack : a systematic review and meta-analysis", Stroke, 45, pp.520~526 (2014)
  27. Leyden JM, "Adelaide stroke incidence study: declining stroke rates but many preventable cardioembolic strokes", Stroke, 44, pp.1226~1231 (2013)
  28. Lee SR, "Current prevalence of atrial fibrillation according to the regions and socioeconomic status in Korean population", KSC 2017 Abstract No.610038, ~ (2017)
  29. January CT, "2014 AHA", ACC, American Heart Association Task Force on practice guidelines and the Heart Rhythm Society, pp.J Am Coll Cardiol, 2014[DOI]
  30. Kirchhof P, "2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS", Eur Heart J, 37, pp.2893~2962 (2016)
  31. 정병천, "The Korean Heart Rhythm Society’s 2014 Statement on Antithrombotic Therapy for Patients with Nonvalvular Atrial Fibrillation: Korean Heart Rhythm Society", Korean Circulation Journal, 45(01), pp.9~19 (2015), 대한심장학회
  32. Olesen JB, "Validation of risk stratification schemes for predicting stroke and thromboembolism in patients with atrial fibrillation: nationwide cohort study", BMJ, 342, pp.d124~ (2011)
  33. Chao TF, "Using the CHA2DS2-VASc score for refining stroke risk stratification in ‘low-risk’ Asian patients with atrial fibrillation", J Am Coll Caridol, 64, pp.1658~1665 (2014)
  34. Guo Y, "Validation of contemporary stroke and bleeding risk stratification scores in non-anticoagulated Chinese patients with atrial fibrillation", Int J Cardiol, 168, pp.904~909 (2013)
  35. Tomita H, "Validation of risk scoring system excluding female sex from CHA2DS2-VASc in Japanese patients with nonvalvular atrial fibrillation – subanalysis of the J-RHYTHM registry", Circ J, 79, pp.1719~1726 (2015)
  36. Hung Y, "Is an oral anticoagulant necessary for young atrial fibrillation patients with a CHA2DS2-VASc score of 1 (men) or 2(women)?", J Am Heart Asssoc, 5(10), pp.3003839~ (2016)
  37. Chao TF, "Validation of a modified CHA2DS2-VASc score for stroke risk stratification in Asian patients with atrial fibrillation: a nationwide cohort study", Stroke, 47, pp.2462~2469 (2016)
  38. Kang SH, "Risk of ischemic stroke in patients with non-valvular atrial fibrillation not receiving oral anticoagulants – Korean nationwide population-based study", Circ J, 81, pp.1158~1164 (2017)
  39. , vascular disease, age 65-74, female) for stroke in Asian patients with atrial fibrillation: a Korean nationwide sample cohort study, "Stroke", 2017, 1524~1530
  40. Lip GY, "Identifying patients at high risk for stroke despite anticoagulation: a comparison of contemporary stroke risk stratification schemes in an anticoagulated atrial fibrillation cohort", Stroke, 41, pp.2731~2718 (2010)
  41. Chao TF, "Comparisons of CHADS2 and CHA2DS2-VASc scores for stroke risk stratification in atrial fibrillation: Which scoring system should be used for Asians?", Heart Rhythm, 13, pp.46~53 (2016)
  42. Suzuki S, "Incidence of ischemic stroke in Japanese patients with atrial fibrillation not receiving anticoagulation therapy – pooled analysis of the Shinken Dababase, J-RHYTHM Registry, and Fushimi AF Registry", Circ J, 79, pp.432~438 (2015)
  43. Eckman MH, "Moving the tipping point: the decision to anticoagulated patients with atrial fibrillation", Circ Cardiovasc Q ual Outcomes, 4, pp.14~21 (2011)
  44. Freedman B, "Stroke prevention in atrial fibrillation", Lancet, 388, pp.806~817 (2016)
  45. Bungard TJ, "Why do patients with atrial fibrillation not receive warfarin?", Arch Intern Med, 160, pp.41~46 (2000)
  46. Ogilvie IM, "Underuse of oral anticoagulants in atrial fibrillation: a systematic review", Am J Med, 123, pp.638~645 (2010)
  47. Lee IH, "Underutilization of warfarin for stroke prophylaxis in patients with atrial fibrillation or atrial flutter in Korea", Int J Cardiol, 66, pp.475~481 (2015)
  48. Cha MJ, "Effectiveness and safety of non-vitamin K antagonist oral anticoagulants in Asian patients with atrial fibrillation", Stroke, 48, pp.3040~3048 (2017)
  49. Camm AJ, "2012 focused update of the ESC Guidelines for the management of atrial fibrillation: an update of the 2010 ESC Guidelines for the management of atrial fibrillation. Developed with the special contribution of the European Heart Rhythm Association", Eur Heart J, 33, pp.2719~2747 (2012)

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