알레르기 비염 마우스 모델에서 Toll-like Receptor 2의 역할
Role of Toll-like receptor 2 in a Mouse Model of Allergic Rhinitis
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Abstract
Background and Objectives：Mammalian Toll-like receptors (TLR) participate innate immune responses to microbial path-imune responses. The objective of this study is to determine whether TLR 2 stimulation in vivo would modulate subsequent allergic responses in an Aspergillus fumigatus (Af) murine model of allergic rhinitis (AR). Materials and Method：Mice were sensitized via intraperitoneal injection with Af antigen and alum, and received a series of three daily intranasal Af antigen chal-lenge. A TLR 2 agonist, PamCys was administrated intranasally one day before sensitization or one day before the first intranasal Results：PamCys decreased the al-lergen induced nasal recruitment of eosinophils and interleukin (IL)-5 in nasal lavage fluids compared with mice treated with no PamCys. Serologic data revealed that PamCys downregulated Af-specific IgE in the sera of PamCys-treated mice. In addition, spleen cells from the PamCys-treated mice displayed attenuated Af-specific IL-4 and IL-5, but increased interferon (IFN)- and imunosuppressive IL-10. Conclusion：model by shifting T helper 2 (Th2) biased imune parameters towards Th1 dominance. (Korean J Otorhinolaryngol-Head Neck Surg 2007 ;50 :989-95)
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