Aspergillus 알레르기 비염 마우스 모델에서의 비만세포의 역할
Role of Mast Cells in a Aspergillus Murine Model of Allergic Rhinitis
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Abstract
Background and Objectives：Mast cells are the main effector cells in the immediate phase of the allergic responses. To evaluatethe role of mast cells on the development of allergen-induced eosinophilic inflammation in a murine model of allergic rhinitis(AR), we compared the responses of mast cell deficient (W/Wv) mice with congenial normal (W/W+) mice. Materials and Method：Mice were sensitized intranasally with an extract of Aspergillus fumigatue (Af) for 3 weeks, and challenged intranasallywith a single dose (acute model) or single dose every day for 5 consecutive days (chronic model). Interleukin (IL)-5 in nasallavage fluids (NLF), histologic examination and Af-specific immunoglobulins (Ig) were examined in W/Wv mice and W/W+mice. Results：In the sensitized W/Wv mice, the number of eosinophils in the nasal mucosa and IL-5 in NLF after repeatedallergen challenge were not significantly different from those of W/W+ mice. In contrast, the number of eosinophils in the nasalmucosa and IL-5 in NLF after single allergen challenge were partially attenuated in W/Wv mice. The levels of Af-specific IgEand IgG1 in both acute and chronic models were not different between W/Wv mice and W/W+ mice. Conclusion：These findingssuggest that eosinophilic inflammation caused by repeated allergen challenge are independent of mast cells in this AR model.(Korean J Otolaryngol 2006;49:912-7)
참고문헌 (19)
- "Allergen-induced bronchial hyperreactivity and eosinophilicinflammation occur in the absence of IgE in a mouse modelof asthma", 94, pp.1344~1349 (1997)
- "A murine model of allergic rhinitis:Studies on the roleof IgE in pathogenesis and analysis of the eosinophil influx elicited byallergen and eotaxin", 102, pp.65~74 (1998)
- "Mast cells", 77, pp.1033~1079 (1997)
- "Mast cells modulate allergic pulmonary eosinophilia in mice", 12, pp.404~409 (1995)
- "T cells are necessary for Th2 cytokine production and eosinophilaccumulation in airways of antigen-challenged allergic mice", 75, pp.75~83 (1995)
- "Anti-interleukin 5 but not anti-IgE prevents airwayinflammation and airway hyperresponsiveness", 160, pp.934~941 (1999)
- "Mucosal and systemic inflammatory changes in allergicrhinitis and asthma:A comparison between upper and lower airways", 33, pp.579~587 (2003)
- "Carbohydrates expressed on Aspergillus fumigatus induce invivo allergic Th2-type response", 32, pp.776~782 (2002)
- "Therole of human mast cell-derived cytokines in eosinophil biology", 24, pp.271~281 (2004)
- "Bone marrow events in animal models of allergic inflammationand hyperresponsiveness", 106, pp.235~241 (2000)
- "Interleukin5 deficiency abolishes eosinophilia, airways hyperreactivity, and lungdamage in a mouse asthma model", 183, pp.195~201 (1996)
- "Kinetics of eotaxin generation and its relationshipto eosinophil accumulation in allergic airways disease:Analysis in aguinea pig model in vivo", 186, pp.601~612 (1997)
- "Cytokine and eosinophil responses in the lung, peripheral blood, andbone marrow compartments in a murine model of allergen-inducedairways inflammation", 16, pp.510~520 (1997)
- "Mast cells play a partial role in allergen-induced subepithelialfibrosis in a murine model of allergic asthma", 33, pp.705~713 (2003)
- "Role of mast cells eosinophilsand IL-5 in the development of airway hyperresponsivenessin sensitized mice", 26, pp.642~647 (1996)
- "Development of eosinophilic airway inflammation andairway hyperresponsiveness in mast cell-deficient mice", 186, pp.449~454 (1997)
- "Mast cells can amplify airway reactivity andfeatures of chronic inflammation in an asthma model in mice", 192, pp.455~462 (2000)
- "Role of immunoglobulin E and mast cellsin murine models of asthma", 36, pp.821~827 (2003)
- "IL-4- and IL-5-positive T lymphocytes, eosinophils, and mastcells in allergen-induced late-phase cutaneous reactions in atopic subjects", 101, pp.222~230 (1998)