태아기 성호르몬이 여성의 알츠하이머병의 발병에 미치는 영향: 2D/4D 손가락 길이 비율을 이용한 단면 연구
Effect of Fetal Sex Hormone on the Development of Alzheimer’s Disease in Woman: A Cross-Sectional Study Using 2D/4D Digit Length Ratio
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Objective: The purpose of this study is to investigate an association between sex-hormone exposure during fetal period and the development of Alzheimer’s disease (AD). Methods: Twenty four AD patients and 25 normal controls were included from Memory Impairment Clinic of Pusan National University Hospital in Korea. Subjects are measured the ratio of the length of the second to the fourth digit (2D/4D) to estimate fetal sex-hormone exposure. Analysis of covariance was used to investigate an association between fetal sex-hormone exposure and the development of AD after adjusting age, education level, Korean Mini-Mental Status Examination and head circumference. Results: We found that the females with AD had significantly lower 2D/4D ratios than the female controls. In the females with AD, the 2D/4D ratios in the left hand was 0.021 and 0.017 in the right hand compared with the controls. Conclusion: Our findings suggest that the development of AD in female may be related with higher testosterone and lower estrogen exposure during fetal period.
Abstract
Objective: The purpose of this study is to investigate an association between sex-hormone exposure during fetal period and the development of Alzheimer’s disease (AD). Methods: Twenty four AD patients and 25 normal controls were included from Memory Impairment Clinic of Pusan National University Hospital in Korea. Subjects are measured the ratio of the length of the second to the fourth digit (2D/4D) to estimate fetal sex-hormone exposure. Analysis of covariance was used to investigate an association between fetal sex-hormone exposure and the development of AD after adjusting age, education level, Korean Mini-Mental Status Examination and head circumference. Results: We found that the females with AD had significantly lower 2D/4D ratios than the female controls. In the females with AD, the 2D/4D ratios in the left hand was 0.021 and 0.017 in the right hand compared with the controls. Conclusion: Our findings suggest that the development of AD in female may be related with higher testosterone and lower estrogen exposure during fetal period.
참고문헌 (17)
- Andersen K, "Gender differences in the incidence of AD and vascular dementia: the EURODEM Studies. EURODEM Incidence Research Group", Neurology, 53, pp.1992~1997 (1999)
- Bachman DL, "Prevalence of dementia and probable senile dementia of the Alzheimer type in the Framingham Study", Neurology, 42, pp.115~119 (1992)
- Ruitenberg A, "Incidence of dementia: does gender make a difference?", Neurobiol Aging, 22, pp.575~580 (2001)
- Barnes LL, "Sex differences in the clinical manifestations of Alzheimer disease pathology", Arch Gen Psychiatry, 62, pp.685~691 (2005)
- Sinforiani E, "Impact of gender differences on the outcome of Alzheimer’s disease", Dement Geriatr Cogn Disord, 30, pp.147~154 (2010)
- Callahan MJ, "Augmented senile plaque load in aged female beta-amyloid precursor protein-transgenic mice", Am J Pathol, 158, pp.1173~1177 (2001)
- Pike CJ, "Sex and the development of Alzheimer’s disease", J Neurosci Res, 95, pp.671~680 (2017)
- Rocca WA, "Oophorectomy, estrogen, and dementia: a 2014 update", Mol Cell Endocrinol, 389, pp.7~12 (2014)
- Hogervorst E, "Should surgical menopausal women be treated with estrogens to decrease the risk of dementia?", Neurology, 69, pp.1070~1071 (2007)
- Zuloaga DG, "The role of androgen receptors in the masculinization of brain and behavior : what we’ve learned from the testicular feminization mutation", Horm Behav, 53, pp.613~626 (2008)
- Lee KS, "Cognitive decline is associated with nutritional risk in subjects with small head circumference(HC)", Arch Gerontol Geriatr, 51, pp.105~109 (2010)
- Vladeanu M, "Prenatal sex hormone exposure and risk of Alzheimer disease : a pilot study using the 2D : 4D digit length ratio", Cogn Behav Neurol, 27, pp.102~106 (2014)
- Hönekopp J, "Second to fourth digit length ratio(2D : 4D)and adult sex hormone levels : new data and a meta-analytic review", Psychoneuroendocrinology, 32, pp.313~321 (2007)
- McKhann G, "Clinical diagnosis of Alzheimer’s disease : report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer’s Disease", Neurology, 34, pp.939~944 (1984)
- Ji Yang Kim, "Standardization of the Korean Version of the Geriatric Depression Scale: Reliability, Validity, and Factor Structure", PSYCHIATRY INVESTIGATION, 5(4), pp.232~238 (2008), 대한신경정신의학회
- Lutchmaya S, "2nd to 4th digit ratios, fetal testosterone and estradiol", Early Hum Dev, 77, pp.23~28 (2004)
- Zheng Z, "Developmental basis of sexually dimorphic digit ratios", Proc Natl Acad Sci U S A, 108, pp.16289~16294 (2011)