정신분열병 환자와 정상 대조군 간의 검지-약지 길이 비의 차이
The Differences of 2nd to 4th Digit Length Ratio between Schizophrenia Patients and Normal Controls
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초록
본 연구는 태내 성호르몬의 지표라고 생각되는 검지-약지길이 비와 정신분열병의 관계를 알아보고자 하였다. 정신분열병 환자군과 정상 대조군 사이에 검지-약지 길이 비는 유의미한 차이를 보이지 않았고, 정신분열병 환자군의 발병연령과 검지-약지 길이 비간의 상관관계 분석에서도 유의미한 차이를 보이지 않았다. 그러나 정상 대조군에서는 남녀 간에 검지-약지 길이 비가 유의미한 차이를 보였지만, 정신분열병 환자군에서는 남녀 간에 통계적으로 유의미한 차이를 보이지 않았다. 이는 태아기 성호르몬의 이상이 정신분열병의 발생에 epigenetics 혹은 두뇌 구조 변화에 대한 직접적인 효과 등의 기전을 통해 모종의 영향을 미쳤을 가능성을 시사한다. 향후 본 연구의 제한점을 보완하는 추가 연구들이 필요할 것으로 생각된다.
Abstract
Objectives: The length ratio of the second to the fourth finger (2D：4D) is a known indirect measure of prenatal sex hormone exposure. Sex hormones influence brain development through structural and epigenetic modifications of neurons. We examined the 2D：4D in schizophrenia patients and normal controls to investigate the relationship between prenatal sex hormone exposure and the genesis of schizophrenia. Methods: The participants were 187 schizophrenia patients (94 male, 93 female) and 190 normal controls (95 male, 95 female). We determined handedness via the Edinburgh Handedness Inventory and age of onset of schizophrenia via clinical records or directly questioning the patients. We measure digit length using vernier caliper and performed T-tests, ANOVA, and ANCOVA to analyze the data. Results: There were no significant 2D：4D differences between schizophrenic participants and normal controls. Also, there was no significant correlation between the 2D：4D and the age of onset of schizophrenia. Among the controls, the 2D：4D was significantly higher (more “feminized”) in females than in males (F=4.937, p=.027). But, there were no significant 2D：4D sex differences among the schizophrenia patients (F=3.429, p=.066). Conclusion: These results imply that sex hormone changes during fetal development might play some role in the development of schizophrenia.
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