간헐외사시 환자에서 주시안과 비주시안의 망막 및 맥락막혈관의 차이 비교
Differences in Retinal and Choroidal Vessels between Dominant and Non-dominant Eyes in Intermittent Exotropia
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목적: 간헐외사시 환자의 망막중심오목무혈관부위(foveal avascular zone, FAZ)의 넓이와 혈관 밀도(vascular density, VD) 맥락막두께(choroidal thickness, CT)를 측정하여 주시안을 구분할 수 있는지 알아보고자 하였다. 대상과 방법: 34명의 간헐외사시 환자를 대상으로 프리즘교대가림검사를 통해 주시안을 감별한 후, 빛간섭단층혈관조영술을 시행하여 양안의 표층 FAZ (superficial FAZ, SFAZ)와 심부 FAZ (deep FAZ, DFAZ)의 넓이 및 표층망막혈관총에서의 망막중심오목 기준반경 1 mm와 3 mm의 혈관 밀도(1-mm fovea, 3-mm parafovea superficial capillary plexus density, SCPD), CT를 측정하여 일표본 t-검정으로 양안을 비교하고 피어슨 상관분석으로 양안의 상관관계를 분석하였다. 결과: 주시안과 비주시안의 SFAZ 및 DFAZ의 넓이와 1-mm fovea, 3-mm parafovea SCPD 및 CT는 양의 상관관계를 보였다. SFAZ 및 DFAZ의 넓이와 3-mm parafovea SCPD, CT는 양안에서 통계적으로 유의한 차이가 없었으나, 1-mm fovea SCPD는 비주시안이 주시안보다 통계적으로 유의하게 높았다(p=0.039). 결론: 간헐외사시 환자는 비주시안의 1-mm fovea SCPD가 주시안보다 높고, 이는 양안의 망막이 어느 정도 발달된 후에 이차적으로 비주시안의 FAZ 주변 모세혈관들이 발달하기 때문인 것으로 추정된다.
Abstract
Purpose: To distinguish the dominant eye in patients with intermittent exotropia by comparing the width of the foveal avascular zone (FAZ), the vascular density (VD), and the choroidal thickness (CT) in both eyes. Methods: A total of 34 subjects with intermittent exotropia were enrolled. Optical coherence tomography angiography (OCTA) was performed after discrimination of the dominant eye using a prism cover test (PCT). FAZ widths in the superficial capillary plexus (referred to here as superficial FAZ or SFAZ) and in the deep capillary plexus (deep FAZ or DFAZ); VDs of the 1-mm fovea and 3-mm parafovea, specifically the superficial capillary plexus density (SCPD); and CT measured by OCTA were compared between both eyes using a one-sample t-test. These abovementioned parameters were compared between dominant and non-dominant eyes through Pearson’s correlation analysis. Results: The widths of SFAZ and DFAZ, the 1-mm fovea and 3-mm parafovea SCPDs, and CT of dominant eye showed positive correlations with respect to the non-dominant eye. Although there was no statistically significant difference in SFAZ and DFAZ widths, the 3-mm parafovea SCPD, or CT between eyes, the 1-mm fovea SCPD in the non-dominant eye showed a statistically significant higher density than that of the dominant eye (p = 0.039). Conclusions: Our results suggest that the higher 1-mm fovea SCPD in the non-dominant eye is due to the secondary development of capillaries around the FAZ of the non-dominant eye after the retina of both eyes had developed to some extent.
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