전정신경염의 양·한약 병용 치료에 대한 체계적 문헌 고찰 및 메타분석 : 중국 논문을 중심으로

Abstract

Objectives : The aim of this study is to evaluate the Effect and safety of western medicine and herbal medicine combination treatment for vestibular neuritis. Methods : We used 2 databases(Wanfang Med Online, CNKI) to search Randomized Controlled Trials(RCTs) that used western medicine and herbal medicine combination treatment for vestibular neuritis. Results : We selected 7 RCTs in this study, and all studies compared western medicine and herbal medicine combination treatment with western medicine alone treatment. The most frequently used medicine was Wind-heat dissipating medicinal(發散風熱藥). Forsythiae Fructus(連翹) was the most frequently used herb. The Total Effective Rate(TER) of treatment group was statistically higher than that of control group(RR=1.16, 95% CI=1.02 to 1.32, P=0.02, I2=50%, P=0.11) in Meta-analysis of 4 studies. The Platelet/Lymphocyte Ratio(PLR) of treatment group was statistically lower than that of control group(SMD=-2.26, 95% CI=-2.67 to –1.84, P<0.0001, I2=0%, P=0.63) in Meta-analysis of 2 studies. The Visual Symptom Index Dizziness was statistically lower than that of control group(MD=-1.90, 95% CI=-2.39 to –1.40, P<0.0001, I2=0%, P=0.41) in Meta-analysis of 2 studies. Conclusion : Using western medicine and herbal medicine combination treatment can be more effective in improving vestibular neuritis than using western medicine alone. But better-designed studies are needed because heterogeneity existed between studies and the quality of the studies needs to be improved.