백서에서 바질 에센셜 오일의 항통각 효과
Antinociceptive Effects of the Essential Oil of Ocimum Basilicum in Mice
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초록
Background: The essential oil of Ocimum basilicum (EOOB) has a pleasant aroma and is known to have antimicrobial and insecticidal activities. In addition, it is used as a pain reliever in folk medicine. However, there are few reports on the antinociceptive activities of EOOB. Methods: This study examined the antinociceptive effects of EOOB using formalin and a plantar test in mice. In the formalin test, EOOB (50 ㎎/㎏, 100 ㎎/㎏, 150 ㎎/㎏) was administered intraperitoneally and the licking time of the mice was measured. In the plantar test, intraperitoneal EOOB (50 ㎎/㎏, 100 ㎎/㎏) was administered and the withdrawal latency was measured using the Hargreaves method. Results: In the formalin test, EOOB (50 ㎎/㎏, IP) showed significant decreases in licking time in the second phase. On the other hand, in the plantar test, there were no significant effects in any of the groups examined. Conclusions: These results support the traditional use of EOOB for the treatment of painful conditions. However, there is a need for more research to determine the active chemical constituents and the precise mechanism.
Abstract
Background: The essential oil of Ocimum basilicum (EOOB) has a pleasant aroma and is known to have antimicrobial and insecticidal activities. In addition, it is used as a pain reliever in folk medicine. However, there are few reports on the antinociceptive activities of EOOB. Methods: This study examined the antinociceptive effects of EOOB using formalin and a plantar test in mice. In the formalin test, EOOB (50 ㎎/㎏, 100 ㎎/㎏, 150 ㎎/㎏) was administered intraperitoneally and the licking time of the mice was measured. In the plantar test, intraperitoneal EOOB (50 ㎎/㎏, 100 ㎎/㎏) was administered and the withdrawal latency was measured using the Hargreaves method. Results: In the formalin test, EOOB (50 ㎎/㎏, IP) showed significant decreases in licking time in the second phase. On the other hand, in the plantar test, there were no significant effects in any of the groups examined. Conclusions: These results support the traditional use of EOOB for the treatment of painful conditions. However, there is a need for more research to determine the active chemical constituents and the precise mechanism.
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