라벤더 오일의 통증완화 효과
Inhibitory Effect of Lavender Essential Oil on Formalin-induced Ultrasonic Vocalizations in Rats
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초록
Formalin-induced 22-kHz ultrasonic vocalizations by rats have been implicated to be a behavioral marker of negative affective state. Lavender essential oil is predominantly used as a relaxant, sedative and anxiolytic action in aromatherapy. The aim of this study was to evaluate whether there inhibition effect in lavender aganist to formalin–induced negative affective state, By measuring 22-kHz frequency ultrasonic vocalizations in rats. Increased 22-kHz frequency ultrasonic vocalizations were monitored after injecting of 5% formalin on hindpaw. Lavender essential oil showed inhibition effect against formalin-induced 22-kHz ultrasonic vocalizations with no affect comparing to the pre-treatment 22-kHz ultrasonic calls. These results suggest that formalin-induced negative affective state can be inhibited by lavender essential oil.
Abstract
Formalin-induced 22-kHz ultrasonic vocalizations by rats have been implicated to be a behavioral marker of negative affective state. Lavender essential oil is predominantly used as a relaxant, sedative and anxiolytic action in aromatherapy. The aim of this study was to evaluate whether there inhibition effect in lavender aganist to formalin–induced negative affective state, By measuring 22-kHz frequency ultrasonic vocalizations in rats. Increased 22-kHz frequency ultrasonic vocalizations were monitored after injecting of 5% formalin on hindpaw. Lavender essential oil showed inhibition effect against formalin-induced 22-kHz ultrasonic vocalizations with no affect comparing to the pre-treatment 22-kHz ultrasonic calls. These results suggest that formalin-induced negative affective state can be inhibited by lavender essential oil.
참고문헌 (25)
- D. Dubuisson, "The formalin test: a quantitative study of the analgesic effects of morphine, meperidine, and brain stem stimulation in rats and cats", Pain, 4(2), pp.161~ (1977)
- 윤명하, "쥐를 이용한 포르말린 실험 하에서 척수강내 5-Hydroxytryptamine과 그 유형별 작동제들의 항침해효과", Korean Journal of Anesthesiology, 42(4), pp.542~550 (2002), 대한마취통증의학회
- C. J. Woolf, "Thompson, The induction and maintenance of central sensitization is dependent on N-methyl-D-aspartic acid receptor activation: implications for the treatment of post-injury pain hypersensitivity states", Pain, 44(3), pp.293~ (1991)
- R. L. Francis, "22-kHz calls by isolated rats", Nature, 265(5591), pp.236~ (1977)
- T. Tonoue, "Inhibition of shock-elicited ultrasonic vocalization by opioid peptides in the rat: a psychotropic effect", Psychoneuroendocrinology, 11(2), pp.177~ (1986)
- R. J. Blanchard, "Twenty-two kHz alarm cries to presentation of a predator, by laboratory rats living in visible burrow systems", Physiology & behavior, 50(5), pp.967~ (1991)
- S. M. Brudzynski, "Social contacts and production of 50-kHz short ultrasonic calls in adult rats", Journal of Comparative Psychology, 116(2), pp.73~ (2002)
- B. Knutson, "Anticipation of play elicits high-frequency ultrasonic vocalizations in young rats", Journal of Comparative Psychology, 112(1), pp.65~ (1998)
- R. J. Barfield, "The Role of Ultrasonic Vocalizations in the Regulation of Reproduction in Rats", Annals of the New York Academy of Sciences, 474, pp.33~ (1986)
- B. Knutson, "High-frequency ultrasonic vocalizations index conditioned pharmacological reward in rats", Physiology & behavior, 66, pp.639~ (1999)
- J. Burgdorf, "Frequency-modulated 50kHz ultrasonic vocalizations: a tool for uncovering the molecular substrates of positive affect", Neuroscience & Biobehavioral Reviews, 35(9), pp.1831~ (2011)
- B. Knutson, "Ultrasonic vocalizations as indices of affective states in rats", Psychological bulletin, 128(6), pp.961~ (2002)
- O. Alaoui-Ismaili, "Odor hedonics: connection with emotional response estimated by autonomic parameters", Chemical senses, 22(3), pp.237~ (1997)
- G. Buchbauer, "Aromatherapy: evidence for sedative effects of the essential oil of lavender after inhalation", Zeitschrift für Naturforschung C, 46(11-12), pp.1067~ (1991)
- L. Hui, "Chemical composition of lavender essential oil and its antioxidant activity and inhibition against rhinitis related bacteria", African Journal of Microbiology Research, 4, pp.309~ (2010)
- A. M. Aloisi, "Effects of the essential oil from citrus lemon in male and female rats exposed to a persistent painful stimulation", Behav Brain Res, 136(1), pp.127~ (2002)
- J. S. Han, "Computerized analysis of audible and ultrasonic vocalizations of rats as a standardized measure of pain-related behavior", J Neuroscience methods, 141(2), pp.261~ (2005)
- J. S. Han, "mGluR1 and mGluR5antagonists in the amygdala inhibit different components of audible and ultrasonic vocalizations in a model of arthritic pain", Pain, 113(1-2), pp.211~ (2005)
- M. Cline, "Investigation of the anxiolytic effects of linalool, a lavender extract, in the male Sprague-Dawley rat", AANA journal, 76(1), pp.47~ (2008)
- L. M. McCracken, "The assessment of anxiety and fear in persons with chronic pain: A comparison of instruments", Behav Res Ther, 34(11-12), pp.924~ (1996)
- J. Y. Kwon, "The effect of intrathecal morphine, clonidine and MK-801 on the formalin test in the rats", Korean J Anesthesiol, 32, pp.354~ (1997)
- H. Wheeler-Aceto, "The rat paw formalin test: comparison of noxious agents", Pain, 40(2), pp.229~ (1990)
- A. R. Oliverira, "Ultrasonic Rat Vocalizations During the Formalin Test: A Measure of the Affective Dimension of Pain?", Anesthesia and analgesia, 102(3), pp.832~ (2006)
- M.Abdollahi, "Antinociceptive effects of Teucrium polium L. total extract and essential oil in mouse writhing test", Pharmacological Research, 48(1), pp.31~ (2003)
- V. Hajhashemi, "Black cumin seed essential oil, as a potent analgesic and antiinflammatory drug", Phytotherapy Research, 18(3), pp.195~ (2004)