초기임신에서 자궁경부 분비물내 angiogenin 및 interleukin-6 농도와 임신 경과와의 연관성
ASSOCIATION OF ANGIOGENIN AND INTERLEUKIN-6 LEVELS IN CERVICAL DISCHARGE DURING EARLY PREGNANCY, TOGETHER WITH ITS OUTCOME
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Objective To investigate the association between the cervical angiogenin and interleukin-6 levels and its outcome during early pregnancy. Methods One hundred and seventy-fi ve pregnant women were included consecutively at the time of their fi rst prenatal visit after less than 10weeks of gestation. The gestational age was calculated according to their menstrual history and/or ultrasonography. We measured the cervical angiogenin and interleukin-6 levels using ELISA kits. We also measured the maternal serum progesterone concentrations using radioimmunoassay. Spontaneous abortion was defi ned as when a pregnancy ended spontaneously within 20 weeks of gestation. If an index pregnancy lasted longer than 20 weeks of gestation, it was regarded as showing a normal pregnancy outcome. Results Fifty-four pregnancies were excluded because of an incomplete study (n=36) or follow-up loss (n=18). Of the remaining 121pregnancies, spontaneous abortion occurred in 10 pregnancies (8.3%) in which there were no significant gestational agedependent changes in the maternal serum progesterone, cervical angiogenin, and interleukin-6 levels. The maternal serum progesterone, cervical angiogenin, and interleukin-6 levels were not signifi cantly different between the spontaneous abortion group and the normal control group. However, the cervical angiogenin level was significantly decreased in the groups with discordant gestational age and spontaneous abortion compared to the group with concordant gestational age (median, 798.0 pg/mL vs. 723.4pg/mL vs. 1039.8 pg/mL; inter-quartile range, 222.8-1054.7 pg/mL vs. 257.1-1213.3 pg/mL vs. 480.4-1534.4 pg/mL) (P <0.041). Conclusion First trimester cervical angiogenin measurement may be valuable for predicting the early pregnancy outcome.
Abstract
Objective To investigate the association between the cervical angiogenin and interleukin-6 levels and its outcome during early pregnancy. Methods One hundred and seventy-fi ve pregnant women were included consecutively at the time of their fi rst prenatal visit after less than 10weeks of gestation. The gestational age was calculated according to their menstrual history and/or ultrasonography. We measured the cervical angiogenin and interleukin-6 levels using ELISA kits. We also measured the maternal serum progesterone concentrations using radioimmunoassay. Spontaneous abortion was defi ned as when a pregnancy ended spontaneously within 20 weeks of gestation. If an index pregnancy lasted longer than 20 weeks of gestation, it was regarded as showing a normal pregnancy outcome. Results Fifty-four pregnancies were excluded because of an incomplete study (n=36) or follow-up loss (n=18). Of the remaining 121pregnancies, spontaneous abortion occurred in 10 pregnancies (8.3%) in which there were no significant gestational agedependent changes in the maternal serum progesterone, cervical angiogenin, and interleukin-6 levels. The maternal serum progesterone, cervical angiogenin, and interleukin-6 levels were not signifi cantly different between the spontaneous abortion group and the normal control group. However, the cervical angiogenin level was significantly decreased in the groups with discordant gestational age and spontaneous abortion compared to the group with concordant gestational age (median, 798.0 pg/mL vs. 723.4pg/mL vs. 1039.8 pg/mL; inter-quartile range, 222.8-1054.7 pg/mL vs. 257.1-1213.3 pg/mL vs. 480.4-1534.4 pg/mL) (P <0.041). Conclusion First trimester cervical angiogenin measurement may be valuable for predicting the early pregnancy outcome.
참고문헌 (26)
- Scott JR, "Danforth’s obstetrics and gynecology. 8th ed", pp.143~153 (1999), Lippincott Williams & Wilkins
- Batzofin JH, "Effect of vaginal bleeding in early pregnancy on outcome", Obstet Gynecol, 63, pp.515~518 (1984)
- Funderburk SJ, "Outcome of pregnancies complicated by early vaginal bleeding", Br J Obstet Gynaecol, 87, pp.100~105 (1980)
- Fossum GT, "Early detection of pregnancy with transvaginal ultrasound", Fertil Steril, 49, pp.788~791 (1988)
- al-Sebai MA, "The role of a single progesterone measurement in the diagnosis of early pregnancy failure and the prognosis of fetal viability", Br J Obstet Gynaecol, 102, pp.364~369 (1995)
- Kim JI, "The value of a single progesterone measurement in the predictor of early pregnancy failure and the prognosis of fetal viability", Korean J Perinatol, 7, pp.304~308 (1996)
- Strydom DJ, "Amino acid sequence of human tumor derived angiogenin", Biochemistry, 24, pp.5486~5494 (1985)
- Fett JW, "Isolation and characterization of angiogenin, an angiogenic protein from human carcinoma cells", Biochemistry, 24, pp.5480~5486 (1985)
- Weiner HL, "Tissue distribution and developmental expression of the messenger RNA encoding angiogenin", Science, 237, pp.280~282 (1987)
- Rybak SM, "Angiogenin mRNA in human tumor and normal cells", Biochem Biophys Res Commun, 146, pp.1240~1248 (1987)
- Spong CY, "Angiogenin: a marker for preterm delivery in midtrimester amniotic fluid", Am J Obstet Gynecol, 176, pp.415~418 (1997)
- Kolben M, "Angiogenin plasma levels during pregnancy", Am J Obstet Gynecol, 176, pp.37~41 (1997)
- Zetter BR, "Angiogenesis", State of the art. Chest, 93, pp.159~166 (1988)
- Spong CY, "Elevated second-trimester maternal serum hCG: a marker of inadequate angiogenesis", Obstet Gynecol, 91, pp.605~608 (1998)
- Kameda T, "Production of interleukin-6 by normal human trophoblast", Placenta, 11, pp.205~213 (1990)
- Taniguchi T, "The enhanced production of placental interleukin-1 during labor and intrauterine infection", Am J Obstet Gynecol, 165, pp.131~137 (1991)
- Li Y, "Trophoblast-derived tumor necrosis factor-alpha induces release of human chorionic gonadotropin using interleukin-6 (IL-6) and IL-6-receptor-dependent system in the normal human trophoblasts", J Clin Endocrinol Metab, 74, pp.184~191 (1992)
- Matsuzaki N, "Trophoblast-derived transforming growth factor-beta 1 suppresses cytokine-induced, but not gonadotropin-releasing hormone-induced, release of human chorionic gonadotropin by normal human trophoblasts", J Clin Endocrinol Metab, 74, pp.211~216 (1992)
- Matsuzaki N, "Implantation and early pregnancy in humans", pp.229~ (1994), Parthenon Publishing
- Lee PY, "Altered trophoblastic apoptosis in early pregnancy losses", Korean J Obstet Gynecol, 42, pp.1201~1206 (1999)
- Reynolds LP, "Angiogenesis in the female reproductive system", FASEB J, 6, pp.886~892 (1992)
- Cockerill GW, "Angiogenesis: models and modulators", Int Rev Cytol, 159, pp.113~160 (1995)
- Vuckovic M, "Expression of the vascular endothelial growth factor receptor, KDR, in human placenta", J Anat, 188, pp.361~366 (1996)
- Fett JW, "Lysozyme: a major secretory product of a human colon carcinoma cell line", Biochemistry, 24, pp.965~975 (1985)
- Heyl PS, "Maternal serum screening for aneuploid pregnancy by alpha-fetoprotein, hCG, and unconjugated estriol", Obstet Gynecol, 76, pp.1025~1031 (1990)
- Hayashi K, "Serum angiogenin levels during menstrual cycle and pregnancy", Gynecol Obstet Invest