CLINICAL USEFULNESS OF SOLUBLE FMS-LIKE TYROSINE KINASE 1, SOLUBLE ENDOGLIN AND PLACENTAL GROWTH FACTOR IN KOREAN WOMEN WITH PREECLAMPSIA
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Objective To evaluate the clinical signifi cance of soluble fms-like tyrosine kinase1 (sFlt-1), soluble endoglin (sEng) and placental growth factor (PlGF) in preeclampsia. Methods We conducted a case-control study analyzing serum levels of sFlt-1, sEng and PlGF in women with preeclampsia (n=30) and normal pregnancy (n=30) in the third trimester. We calculated the sensitivity, specifi city, positive, and negative predictive values of each peptide in diagnosing preeclampsia. Results The mean serum level of sFlt-1 and sEng in women with preeclampsia was significantly higher than normal pregnancy. But the mean serum level of PIGF had no signifi cant difference between two groups. The cut-off values of sFlt-1 and sEng showing differential signifi cance were 26.3 ng/mL and 21.1 ng/mL each. Then the sensitivity, specifi city, positive predictive value, negative predictive value was all over 80%. Serum levels of sFlt-1 and sEng were not signifi cantly different between intrauterine growth restriction (IUGR) and non-IUGR group among preeclamptic women. Conclusion Serum levels of both sFlt-1 and sEng may be useful in diagnosing patients with preeclampsia. The serum levels of these factors may not correlate with poor perinatal outcomes.
Abstract
Objective To evaluate the clinical signifi cance of soluble fms-like tyrosine kinase1 (sFlt-1), soluble endoglin (sEng) and placental growth factor (PlGF) in preeclampsia. Methods We conducted a case-control study analyzing serum levels of sFlt-1, sEng and PlGF in women with preeclampsia (n=30) and normal pregnancy (n=30) in the third trimester. We calculated the sensitivity, specifi city, positive, and negative predictive values of each peptide in diagnosing preeclampsia. Results The mean serum level of sFlt-1 and sEng in women with preeclampsia was significantly higher than normal pregnancy. But the mean serum level of PIGF had no signifi cant difference between two groups. The cut-off values of sFlt-1 and sEng showing differential signifi cance were 26.3 ng/mL and 21.1 ng/mL each. Then the sensitivity, specifi city, positive predictive value, negative predictive value was all over 80%. Serum levels of sFlt-1 and sEng were not signifi cantly different between intrauterine growth restriction (IUGR) and non-IUGR group among preeclamptic women. Conclusion Serum levels of both sFlt-1 and sEng may be useful in diagnosing patients with preeclampsia. The serum levels of these factors may not correlate with poor perinatal outcomes.
참고문헌 (15)
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