A Case of Pancytopenia with Hyperthyroidism
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초록
There has been an increase in the number of reports of atypical manifestations of Graves’ disease (GD), such as jaundice, anemia, thrombocytopenia and leukopenia. Pancytopenia also rarely occurs in GD. In this paper, a case of pancytopenia with GD that was successfully treated with an anti-thyroid drug is reported. In this case, a 69-year-old woman showed pancytopenia with a normal peripheral blood smear, bone marrow aspiration smear and bone marrow biopsy. Her thyroid function test and thyroid scintigraphy confirmed her hyperthyroid status. Her laboratory abnormality and clinical condition improved after she was treated with an anti-thyroid drug. This is a rare case of pancytopenia associated with GD.
Abstract
There has been an increase in the number of reports of atypical manifestations of Graves’ disease (GD), such as jaundice, anemia, thrombocytopenia and leukopenia. Pancytopenia also rarely occurs in GD. In this paper, a case of pancytopenia with GD that was successfully treated with an anti-thyroid drug is reported. In this case, a 69-year-old woman showed pancytopenia with a normal peripheral blood smear, bone marrow aspiration smear and bone marrow biopsy. Her thyroid function test and thyroid scintigraphy confirmed her hyperthyroid status. Her laboratory abnormality and clinical condition improved after she was treated with an anti-thyroid drug. This is a rare case of pancytopenia associated with GD.
참고문헌 (15)
- Hegazi MO, "Atypical clinical manifestations of Graves’ disease: an analysis in depth", J Thyroid Res, pp.768019~ (2012)
- Hambsch K, "Changes in the blood picture in hyperthyroidism", Z Gesamte Inn Med, 44, pp.300~306 (1989)
- Ansell JE, "Werner and Ingbar’s the thyroid: a fundamental and clinical text", pp.637~652 (1996), Lippincott-Raven Publishers
- Soeki T, "A case of thyrotoxicosis with pancytopenia", Endocr J, 48, pp.385~389 (2001)
- Macaron CI, "Increased serum ferritin levels of hyperthyroidism", Ann Intern Med, 96, pp.617~618 (1982)
- Gianoukakis AG, "Characterization of the anaemia associated with Graves’ disease", Clin Endocrinol (Oxf), 70, pp.781~787 (2009)
- Lima CS, "Pancytopenia in untreated patients with Graves’ disease", Thyroid, 16, pp.403~409 (2006)
- Burns RW, "Pancytopenia due to vitamin B12 deficiency associated with Graves’ disease", Mo Med, 93, pp.368~372 (1996)
- Paydas S, "Peripheral blood findings in thyrotoxicosis", J Islamic Acad Sci, 4, pp.323~325 (1991)
- 신종호, "범혈구감소증이 동반된 그레이브스병 1예", Endocrinology and Metabolism, 24(4), pp.272~276 (2009), 대한내분비학회
- Adrouny A, "Variable presentation of thrombocytopenia in Graves’ disease", Arch Intern Med, 142, pp.1460~1464 (1982)
- Lee AC, "Childhood thrombocytopenia associated with Graves disease is distinct from idiopathic thrombocytopenic purpura", Pediatr Hematol Oncol, 20, pp.39~42 (2003)
- Kebapcilar L, "Recovery from pancytopaenia and liver dysfunction after administration of propylthiouracil for Graves’disease", N Z Med J, 118, pp.U1615~ (2005)
- Chen YH, "Rare presentations of hyperthyroidism-Basedow’s paraplegia and pancytopenia", Am J Emerg Med, 27, pp.258~251 (2009)
- Weitzman SA, "Antineutrophil autoantibodies in Graves’disease. Implications of thyrotropin binding to neutrophils", J Clin Invest, 75, pp.119~123 (1985)