갑상선 수질암과 갑상선 유두암의 충돌종양: 5예 증례보고
Medullary and Papillary Thyroid Carcinoma as a Collision Tumor: Report of Five Cases
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Medullary thyroid carcinoma and papillary thyroid carcinoma are different subtypes of thyroid carcinoma. The concomitant occurrence of medullary thyroid carcinoma and papil-lary thyroid carcinoma as a collision tumor is rare. We describe five cases of medullary and papillary thyroid carcinoma as a collision tumor. Four women and one man underwent thyroidectomy for treatment of thyroid cancer. Collision tumor was then detected by histopathologic finding. Genetic testing, point mutation of the BRAF gene or mutation of the RET gene was performed in three cases. However, only one case had point mutation of the BRAF gene. Exact diagnosis of this uncommon event is important because the strategies for treatment of papillary thyroid carcinoma and medullary thyroid carcinoma are different.
Abstract
Medullary thyroid carcinoma and papillary thyroid carcinoma are different subtypes of thyroid carcinoma. The concomitant occurrence of medullary thyroid carcinoma and papil-lary thyroid carcinoma as a collision tumor is rare. We describe five cases of medullary and papillary thyroid carcinoma as a collision tumor. Four women and one man underwent thyroidectomy for treatment of thyroid cancer. Collision tumor was then detected by histopathologic finding. Genetic testing, point mutation of the BRAF gene or mutation of the RET gene was performed in three cases. However, only one case had point mutation of the BRAF gene. Exact diagnosis of this uncommon event is important because the strategies for treatment of papillary thyroid carcinoma and medullary thyroid carcinoma are different.
참고문헌 (23)
- Rossi S, "Medullary and papillary carcinoma of the thyroid gland occurring as a collision tumour: report of three cases with molecular analysis and review of the literature", Endocr Relat Cancer, 12, pp.281~289 (2005)
- Brandwein-Gensler M, "Collision tumor of the thyroid: a case report of metastatic liposarcoma plus papillary thyroid carcinoma", Head Neck, 26, pp.637~641 (2004)
- Younes N, "Simultaneous medullary and papillary thyroid carcinoma with lymph node metastasis in the same patient: case report and review of the literature", Asian J Surg, 28, pp.223~226 (2005)
- Kimura ET, "High prevalence of BRAF mutations in thyroid cancer: genetic evidence for constitutive activation of the RET", PTCRAS-BRAF signaling pathway in papillary thyroid carcinoma, 2003, pp.63, 1454~1457
- Alberti L, "RET and NTRK1 proto-oncogenes in human diseases", J Cell Physiol, 195, pp.168~186 (2003)
- Marsh DJ, "Somatic mutations in the RET proto-oncogene in sporadic medullary thyroid carcinoma", Clin Endocrinol, 44, pp.249~257 (1996)
- Darwish A, "Simultaneous medullary carcinoma, occult papillary carcinoma and lymphocytic thyroiditis", Malays J Pathol, 17, pp.103~107 (1995)
- Fugazzola L, "Multigenerational familial medullary thyroid cancer (FMTC): evidence for FMTC phenocopies and association with papillary thyroid cancer", Clin Endocrinol, 56, pp.53~63 (2002)
- Gero MJ, "Medullary and papillary carcinomas occurring as a collision tumor: report of a case", Clin Nucl Med, 14, pp.171~174 (1989)
- González-Cámpora R, "Concurrence of a symptomatic encapsulated follicular carcinoma, an occult papillary carcinoma and a medullary carcinoma in the same patient", Histopathology, 21, pp.380~382 (1992)
- Ishida T, "Concurrent medullary carcinoma adjacent to papillary carcinoma of the thyroid--a clinicopathological and electron microscopic study", Gan No Rinsho, 31, pp.1814~1820 (1985)
- Kobayashi K, "Simultaneous occurrence of medullary carcinoma and papillary carcinoma of the thyroid", J Surg Oncol, 59, pp.276~279 (1995)
- Lamberg BA, "Concurrent medullary and papillary thyroid carcinoma in the same thyroid lobe and in siblings", Acta Med Scand, 209, pp.421~424 (1981)
- Lax SF, "Coexistence of papillary and medullary carcinoma of the thyroid gland-mixed or collision tumour? Clinicopathological analysis of three cases", Virchows Arch, 424, pp.441~447 (1994)
- Vantyghem MC, "Thyroid carcinomas involving follicular and parafollicular C cells: seventeen cases with characterization of RET oncogenic activation", Thyroid, 14, pp.842~847 (2004)
- Pastolero GC, "Concurrent medullary and papillary carcinomas of thyroid with lymph node metastases. A collision phenomenon", Am J Surg Pathol, 20, pp.245~250 (1996)
- Mizukami Y, "Mixed medullary-follicular carcinoma of the thyroid gland: a clinicopathologic variant of medullary thyroid carcinoma", Mod Pathol, 9, pp.631~635 (1996)
- Papotti M, "Mixed medullary-follicular carcinoma of the thyroid. A morphological, immunohistochemical and in situ hybridization analysis of 11cases", Virchows Arch, 430, pp.397~405 (1997)
- Brauckhoff M, "Papillary thyroid carcinoma in patients with RET proto-oncogene germline mutation", Thyroid, 12, pp.557~561 (2002)
- Papi G, "Concurrent lymph node metastases of medullary and papillary thyroid carcinoma in a case with RET oncogene germline mutation", Endocr Pathol, 14, pp.269~276 (2003)
- Cerrato A, "Molecular genetics of medullary thyroid carcinoma: the quest for novel therapeutic targets", J Mol Endocrinol, 43, pp.143~155 (2009)
- Nangue C, "Mixed medullary-papillary carcinoma of the thyroid: report of a case and review of the literature", Head Neck, 31, pp.968~974 (2009)
- Volante M, "Mixed medullary-follicular thyroid carcinoma. Molecular evidence for a dual origin of tumor components", Am J Pathol, 155, pp.1499~1509 (1999)