A Case of Concurrent Papillary and Medullary Thyroid Carcinomas Detected as Recurrent Medullary Carcinoma after Initial Surgery for Papillary Carcinoma
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As the prevalence of thyroid carcinoma is rapidly increasing, coexisting subtypes of thyroid carcinomas are often found. However, concurrent papillary and medullary carcinomas in the thyroid gland are extremely rare. We report the case of a 50-year-old man with co-occurrence of multiple papillary and medullary thyroid carcinomas; the latter were undetected at initial diagnosis. Sixty-three months after the initial operation performed because of papillary carcinoma diagnosis, a metastatic lymph node was detected in the left level IV region, which was revealed as medullary carcinoma. The histopathologic results from initial surgery were reviewed, and we found multiple coexisting medullary carcinomas that were not identified initially. The incidence of concurrent papillary and medullary thyroid carcinomas will continue to increase as rates of diagnosis of and surgery for thyroid carcinoma increase. Therefore, surgeons and pathologists should be aware of the possible coexistence of subtypes of thyroid carcinomas to avoid missing concurrent lesions.
Abstract
As the prevalence of thyroid carcinoma is rapidly increasing, coexisting subtypes of thyroid carcinomas are often found. However, concurrent papillary and medullary carcinomas in the thyroid gland are extremely rare. We report the case of a 50-year-old man with co-occurrence of multiple papillary and medullary thyroid carcinomas; the latter were undetected at initial diagnosis. Sixty-three months after the initial operation performed because of papillary carcinoma diagnosis, a metastatic lymph node was detected in the left level IV region, which was revealed as medullary carcinoma. The histopathologic results from initial surgery were reviewed, and we found multiple coexisting medullary carcinomas that were not identified initially. The incidence of concurrent papillary and medullary thyroid carcinomas will continue to increase as rates of diagnosis of and surgery for thyroid carcinoma increase. Therefore, surgeons and pathologists should be aware of the possible coexistence of subtypes of thyroid carcinomas to avoid missing concurrent lesions.
참고문헌 (13)
- Kim WG, "Concurrent occurrence of medullary thyroid carcinoma and papillary thyroid carcinoma in the same thyroid should be considered as coincidental", Clin Endocrinol (Oxf), 72(2), pp.256~263 (2010)
- Machens A, "Simultaneous medullary and papillary thyroid cancer: a novel entity?", Ann Surg Oncol, 19(1), pp.37~44 (2012)
- 유창영, "갑상선에서 독립적으로 발생한 유두암종 및 수질암종- 3예 보고 -", Journal of Pathology and Translational Medicine, 41(3), pp.207~212 (2007), 대한병리학회
- Cooper DS, "Revised American Thyroid Association management guidelines for patients with thyroid nodules and differentiated thyroid cancer", Thyroid, 19(11), pp.1167~1214 (2009)
- 유승희, "한 환자에서 동시에 발견된 갑상선 수질암과 유두암", Endocrinology and Metabolism, 22(3), pp.235~240 (2007), 대한내분비학회
- Sadat Alavi M, "Medullary and papillary carcinoma of the thyroid gland occurring as a collision tumor with lymph node metastasis: A case report", J Med Case Rep, 5(1), pp.590~ (2011)
- Pacini F, "European consensus for the management of patients with differentiated thyroid carcinoma of the follicular epithelium", Eur J Endocrinol, 154(6), pp.787~803 (2006)
- Gharib H, "Thyroid nodules: a review of current guidelines, practices, and prospects", Eur J Endocrinol, 159(5), pp.493~505 (2008)
- Lamberg BA, "Concurrent medullary and papillary thyroid carcinoma in the same thyroid lobe and in siblings", Acta Med Scand, 209(5), pp.421~424 (1981)
- Hedinger C, "The WHO histological classification of thyroid tumors: a commentary on the second edition", Cancer, 63(5), pp.908~911 (1989)
- Ljungberg O, "A compound follicular-parafollicular cell carcinoma of the thyroid: a new tumor entity?", Cancer, 52(6), pp.1053~1061 (1983)
- Volante M, "Mixed medullary-follicular thyroid carcinoma. Molecular evidence for a dual origin of tumor components", Am J Pathol, 155(5), pp.1499~1509 (1999)
- "Histopathology", 1994, 183~185
