Diffusion-Enhanced Modified Hemodialyzer
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Abstract
Flow mismatch between blood and dialysate is invariably encountered during conventional hemodialysis, and this deteriorates diffusive mass transfer. A modification of a conventional dialyzer was conceived to prevent this mismatch. The modified dialyzer includes two independent blood flow regions (central and peripheral regions), which were achieved by redesigning the dialyzer cap. Resultantly, the blood stream was divided into two concentric dialyzer regions. Solutes clearances obtained using the modified dialyzers were compared with those of conventional dialyzers. Solutes clearances by conventionaldialyzers were uniform, but solutes clearances by modified dialyzers were found to be dependent on the simulated blood split into dialyzer central and peripheral regions. Maximal clearances using the modified dialyzer were improved by up to approximately 7.6% for urea and 7.3% for creatinine, as compared with those of conventional dialyzers. More optimizations are required for clinical applications, but the finding that blood flowrates through central and peripheral fiber bundles can be easily regulated is encouraging.
참고문헌 (13)
- J. T. Daugirdas, "Physiologic Principles and Urea Kinetic Modeling", pp.15~45 (2000), Lippincott Williams & Wilkins
- C. Ronco, "Blood and dialysate flow distributions in hollow-fiber hemodialyzers analyzed by computerized helical scanning technique", 13(1), pp.S53~61 (2002)
- T. Osuga, "Detection of small degree of nonuniformity in dialysate flow in hollow-fiber dialyzer using proton magnetic resonance imaging", 22(3), pp.417~420 (2004)
- C. Ronco, "Dialysate flow distribution in hollow fiber hemodialyzers with different dialysate pathway configurations", 23(9), pp.601~609 (2000)
- A. Brendolan, "Dialytic performance evaluation of Rexeed a new polysulfone- based dialyzer with improved flow distributions", 28(10), pp.966~975 (2005)
- F. Gastaldon, "Effects of novel manufacturing technology on blood and dialysate flow distribution in a new low flux "alpha Polysulfone hemodialyzer", 26(2), pp.105~112 (2003)
- C. K. Poh, "Effect of spacer yarns on the dialysate flow distribution of hemodialyzers: a magnetic resonance imaging study", 49(4), pp.440~448 (2003)
- Z. Liao, "A modified equivalent annulus model for the hollow fiber hemodialyzer", 27(2), pp.110~117 (2004)
- C. Ronco, "Impact of spacing filaments external to hollow fibers on dialysate flow distribution and dialyzer performance", 20(5), pp.261~266 (1997)
- W. R. Clark, "Effect of dialysate-side mass transfer resistance on small solute removal in hemodialysis", 18(4), pp.260~263 (2000)
- Z. Huang, "A new method to evaluate the local clearance at different annular rings inside hemodialyzers", 49(6), pp.692~697 (2003)
- J. K. Unger, "Thermography as potential real-time technique to assess changes in flow distribution in hemofiltration", 69(3), pp.520~525 (2006)
- M. C. Yang, "Influence of design of the hemodialyzer inlet chamber on red blood cell damage during hemodialysis", 47(1), pp.92~96 (2001)