부검 실무에서 시험지 검사법(Dipstick Test)을 이용한 눈 유리체액 당 검사의 효용성
Usefulness of Dipstick Test for Vitreous Glucose in Autopsy Practice
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The concentration of glucose in the vitreous humor serves as an important diagnostic marker for diabetic mellitus in post-mortem examinations, as the vitreous humor can be easily collected and the glucose test using vitreous humor is not significantly affected by cell autolysis and hemolysis. For a quick and effective glucose test, we suggest a dipstick test of the vitreous humor during autopsy. The results were evaluated and compared with other methods for significance testing. In this study, vitreous humor was analyzed from 257 autopsy cases. Qualitative concordance rate of the dipstick test for glucose and the hexokinase test was 98.7%, positive prediction rate was 89.6%, and negative prediction rate was 100%. However, there was no significant correlation between the dipstick glucose test and the hexokinase test. We conclude that the dipstick glucose test is effective and useful for post-mortem glucose screening testing and for additional post-mortem diabetes testing. Recently, the importance of post-mortem glucose testing has increased with the increase in deaths from diabetes complications. The use of the dipstick glucose test in autopsy practice can improve forensic medicine in Korea.
Abstract
The concentration of glucose in the vitreous humor serves as an important diagnostic marker for diabetic mellitus in post-mortem examinations, as the vitreous humor can be easily collected and the glucose test using vitreous humor is not significantly affected by cell autolysis and hemolysis. For a quick and effective glucose test, we suggest a dipstick test of the vitreous humor during autopsy. The results were evaluated and compared with other methods for significance testing. In this study, vitreous humor was analyzed from 257 autopsy cases. Qualitative concordance rate of the dipstick test for glucose and the hexokinase test was 98.7%, positive prediction rate was 89.6%, and negative prediction rate was 100%. However, there was no significant correlation between the dipstick glucose test and the hexokinase test. We conclude that the dipstick glucose test is effective and useful for post-mortem glucose screening testing and for additional post-mortem diabetes testing. Recently, the importance of post-mortem glucose testing has increased with the increase in deaths from diabetes complications. The use of the dipstick glucose test in autopsy practice can improve forensic medicine in Korea.
참고문헌 (5)
- Boulagnon C, "Post-mortem biochemistry of vitreous humor and glucose metabolism: an update", Clin Chem Lab Med, 49, pp.1265~1270 (2011)
- Belsey SL, "Postmortem biochemistry: current applications", J Forensic Leg Med, 41, pp.49~57 (2016)
- Keltanen T, "HbA1c method evaluation for postmortem samples", Forensic Sci Med Pathol, 11, pp.35~39 (2015)
- 박종필, "사후검사를 통한 당뇨병케톤산증의 진단", 대한법의학회지, 40(1), pp.19~22 (2016), 대한법의학회
- Luna A, "Is postmortem biochemistry really useful? Why is it not widely used in forensic pathology?", Leg Med (Tokyo), 11(Suppl 1), pp.S27~S30 (2009)