Immunostimulating effects of polysaccharides extracted from Schisandra chinensis fruits
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Schisandra chinensis is considered useful to maintain homeostasis in human body. In our previous report, Ginsan, a polysaccharide isolated from the root of Panax ginseng, was administrated to mice and could be adapted as an immunostimulator. In this study, S. chinensis polysaccharides were isolated, and their effects were analyzed on Acanthamoeba castellanii and a bacterium. There were no obscure changes to A. castellanii trophozoites (e.g., membrane shrinkage, bigger vacuoles, motility). However, a higher concentration of the S. chinensis polysaccharides used to treat A. castellanii trophozoites induced a higher increase in the numbers of the amoebae. When the macrophages were pretreated with the polysaccharides, the polysaccharides induced a greater increase of the association of Escherichia coli. Interestingly, treatment of the macrophages with 250 mg of the polysaccharides induced about a two fold greater association than polysaccharide-untreated macrophages. If S. chinensis polysaccharides are used commercially, they will be helpful as supplements for health improvement.
Abstract
Schisandra chinensis is considered useful to maintain homeostasis in human body. In our previous report, Ginsan, a polysaccharide isolated from the root of Panax ginseng, was administrated to mice and could be adapted as an immunostimulator. In this study, S. chinensis polysaccharides were isolated, and their effects were analyzed on Acanthamoeba castellanii and a bacterium. There were no obscure changes to A. castellanii trophozoites (e.g., membrane shrinkage, bigger vacuoles, motility). However, a higher concentration of the S. chinensis polysaccharides used to treat A. castellanii trophozoites induced a higher increase in the numbers of the amoebae. When the macrophages were pretreated with the polysaccharides, the polysaccharides induced a greater increase of the association of Escherichia coli. Interestingly, treatment of the macrophages with 250 mg of the polysaccharides induced about a two fold greater association than polysaccharide-untreated macrophages. If S. chinensis polysaccharides are used commercially, they will be helpful as supplements for health improvement.
참고문헌 (19)
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