Investigation of the Roles of Cyclooxygenase-2 and Galectin-3 Expression in the Pathogenesis of Premenopausal Endometrial Polyps
0
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Background: The pathogenesis and etiology of endometrial polyps has not been elucidated. In this study, we aimed to examine the pathogenic mechanisms of endometrial polyp development using immunohistochemistry. We evaluated the expression of galectin-3 and cyclooxgenase-2 (COX-2) during the menstrual cycle in premenopausal women with endometrial polyps or normal endometrium. Methods: Thirty-one patients with endometrial polyps and 50 healthy control patients were included in this study. The levels of expression of COX-2 and galectin-3 were studied by immunohistochemistry. Results: The percentage of COX-2–positive cells and the intensity of COX-2 staining in the endometrium did not vary during the menstrual cycle either in the control group or in patients with endometrial polyps. However, expression of galectin-3 was significantly lower in endometrial polyps and during the proliferative phase of the endometrium compared with the secretory phase. Conclusions: Our data suggests that the pathogenesis of endometrial polyps does not involve expression of COX-2 or galectin-3.
Abstract
Background: The pathogenesis and etiology of endometrial polyps has not been elucidated. In this study, we aimed to examine the pathogenic mechanisms of endometrial polyp development using immunohistochemistry. We evaluated the expression of galectin-3 and cyclooxgenase-2 (COX-2) during the menstrual cycle in premenopausal women with endometrial polyps or normal endometrium. Methods: Thirty-one patients with endometrial polyps and 50 healthy control patients were included in this study. The levels of expression of COX-2 and galectin-3 were studied by immunohistochemistry. Results: The percentage of COX-2–positive cells and the intensity of COX-2 staining in the endometrium did not vary during the menstrual cycle either in the control group or in patients with endometrial polyps. However, expression of galectin-3 was significantly lower in endometrial polyps and during the proliferative phase of the endometrium compared with the secretory phase. Conclusions: Our data suggests that the pathogenesis of endometrial polyps does not involve expression of COX-2 or galectin-3.
참고문헌 (28)
- Neto LC, "Expression of p53 protein in the endometrial polyp in postmenopausal women", Eur J Gynaecol Oncol, 34, pp.509~512 (2013)
- Clevenger-Hoeft M, "Sonohysterography in premenopausal women with and without abnormal bleeding", Obstet Gynecol, 94, pp.516~520 (1999)
- Droegemueller W, "Comprehensive gynecology", pp.440~492 (2001), Mosby Inc
- Inceboz US, "Hormone receptor expressions and proliferation markers in postmenopausal endometrial polyps", Gynecol Obstet Invest, 61, pp.24~28 (2006)
- Sant’Ana de Almeida EC, "Immunohistochemical expression of estrogen and progesterone receptors in endometrial polyps and adjacent endometrium in postmenopausal women", Maturitas, 49, pp.229~233 (2004)
- Kendall RL, "Identification of a natural soluble form of the vascular endothelial growth factor receptor, FLT-1, and its heterodimerization with KDR", Biochem Biophys Res Commun, 226, pp.324~328 (1996)
- Juyeon Lee, "Immunohistochemical localization of galectin-3 in the granulomatous lesions of paratuberculosis-infected bovine intestine", Journal of Veterinary Science, 10(3), pp.177~180 (2009), 대한수의학회
- Sakaki M, "Clinical significance of galectin-3 in clear cell renal cell carcinoma", J Med Invest, 57, pp.152~157 (2010)
- Topcu HO, "Risk factors for endometrial hyperplasia concomitant endometrial polyps in pre- and postmenopausal women", Asian Pac J Cancer Prev, 15, pp.5423~5425 (2014)
- Costa-Paiva L, "Risk of malignancy in endometrial polyps in premenopausal and postmenopausal women according to clinicopathologic characteristics", Menopause, 18, pp.1278~1282 (2011)
- Noyes RW, "Dating the endometrial biopsy", Fertil Steril, 1, pp.3~25 (1950)
- Harrington DJ, "Tenascin is differentially expressed in endometrium and endometriosis", J Pathol, 187, pp.242~248 (1999)
- Maia H Jr, "Effect of the menstrual cycle and oral contraceptives on cyclooxygenase-2 expression in the endometrium", Gynecol Endocrinol, 21, pp.57~61 (2005)
- Erdemoglu E, "Expression of cyclooxygenase-2, matrix metalloproteinase-2 and matrix metallo proteinase-9 in premenopausal and postmenopausal endometrial polyps", Maturitas, 59, pp.268~274 (2008)
- Bulun SE, "Estrogen biosynthesis in endometriosis: molecular basis and clinical relevance", J Mol Endocrinol, 25, pp.35~42 (2000)
- Wang D, "DNA hypomethylation of the COX-2 gene promoter is associated with up-regulation of its mRNA expression in eutopic endometrium of endometriosis", Eur J Med Res, 17, pp.12~ (2012)
- Carvalho FM, "Functional endometrial polyps in infertile asymptomatic patients : a possible evolution of vascular changes secondary to endometritis", Eur J Obstet Gynecol Reprod Biol, 170, pp.152~156 (2013)
- Maia H Jr, "Cyclooxygenase-2 expression in endometrial polyps during menopause", Gynecol Endocrinol, 21, pp.336~339 (2005)
- Maia H Jr, "Aromatase and cyclooxygenase-2 expression in endometrial polyps during the menstrual cycle", Gynecol Endocrinol, 22, pp.219~224 (2006)
- Pinheiro A, "Expression of hormone receptors, Bcl2, Cox2 and Ki67 in benign endometrial polyps and their association with obesity", Mol Med Rep, 9, pp.2335~2341 (2014)
- Du GP, "of galectin-3in human endometrium", Fudan Univ J Med Sci, 2, pp.143~146 (2006)
- Chiu CG, "Diagnostic utility of galectin-3 in thyroid cancer", Am J Pathol, 176, pp.2067~2081 (2010)
- Cay T, "Immunhistochemical expression of galectin-3 in cancer: a review of the literature", Turk Patoloji Derg, 28, pp.1~10 (2012)
- Nöel JC, "Galectin-3 is overexpressed in various forms of endometriosis", Appl Immunohistochem Mol Morphol, 19, pp.253~257 (2011)
- Brustmann H, "Galectin-3 expression in normal, hyperplastic, and neoplastic endometrial tissues", Pathol Res Pract, 199, pp.151~158 (2003)
- Atlas of tumor pathology, 3rd series. Fascicle 3. Tumors of the uterine corpus and gestational trophoblastic disease, "Silverberg SG", Armed Forces Institute of Pathology, ~ (1992)
- Yang H, "The antiapoptotic effect of galectin-3in human endometrial cells under the regulation of estrogen and progesterone", Biol Reprod, 87, pp.39~ (2012)
- Kumar V, "Robbins and Cotran: pathologic basis of disease", pp.269~342 (2005), Elsevier Saunders