Neuroprotective Effects of the Extracts from the Aerial Parts of Carthamus tinctorius L. on Transient Cerebral Global Ischemia in Rats
0
조회
0
다운로드
4
인용
0
참고문헌
키워드
초록
In traditional Korean and Chinese medicine, safflower (Carthamus tinctorius L.) for the treatment of centralnervous system-related symptoms such as tremor, seizure, stroke and epilepsy. We investigated the effects of safflower couldinfluence cerebral ischemia-induced neuronal and cognitive impairments. Administration of safflower for 1 day(200 ㎎/㎏ body weight, p.o.) increased the survival of hippocampal CA1 pyramidal neurons after transient global brainischemia. And neurological functions measured as short term memory. Post-treatment with safflower for 2 times decreasedthe induction/reduction - induced production of neuronal cell loss from global cerebral ischemia. Safflower markedlydecreased neuronal cell death and also caused a decrease in the content of thiobarbituric acid-reacting substances(TBARS) (55.2 ± 9.4 μmol mg-1) and significant improvement of activities of glutathione (GSH) (27.2 ± 5.0 μmol mg-1) inhippocampus. We conclude that treatment with safflower attenuated learning and memory deficits, and neuronal cell lossinduced by global cerebral ischemia. These results suggest that safflower may be a potential candidate for the treatment ofvascular dementia.
Abstract
In traditional Korean and Chinese medicine, safflower (Carthamus tinctorius L.) for the treatment of centralnervous system-related symptoms such as tremor, seizure, stroke and epilepsy. We investigated the effects of safflower couldinfluence cerebral ischemia-induced neuronal and cognitive impairments. Administration of safflower for 1 day(200 ㎎/㎏ body weight, p.o.) increased the survival of hippocampal CA1 pyramidal neurons after transient global brainischemia. And neurological functions measured as short term memory. Post-treatment with safflower for 2 times decreasedthe induction/reduction - induced production of neuronal cell loss from global cerebral ischemia. Safflower markedlydecreased neuronal cell death and also caused a decrease in the content of thiobarbituric acid-reacting substances(TBARS) (55.2 ± 9.4 μmol mg-1) and significant improvement of activities of glutathione (GSH) (27.2 ± 5.0 μmol mg-1) inhippocampus. We conclude that treatment with safflower attenuated learning and memory deficits, and neuronal cell lossinduced by global cerebral ischemia. These results suggest that safflower may be a potential candidate for the treatment ofvascular dementia.
참고문헌 (29)
- Baxter MG, "Presynaptic markers of cholinergic function in the rat brain : relationship with aged and cognitive status", Neuroscience, 89, pp.771~779 (1999)
- Burda J, "Evidence for a role of second pathophysiological stress in prevention of delayed neuronal death in the hippocampal CA1 region", Neurochemical Research, 30, pp.1397~1405 (2005)
- Draper HH, "A comparative evaluation of thiobarbituric acid methods for the determination of malondialdehyde in biological materials", Journal of Free Radicals in Biology &Medicine, 15, pp.353~363 (1993)
- Doaa AE, "Hypericum perforatum extract demonstrates antioxidant properties against elevated rat brain oxidative status induced by amnestic dose of scopolamine", Pharmacology Biochemistry &Behavior, 76, pp.525~533 (2003)
- Ellman GL, "A new and rapid colorimetric determination of acetylcholinesterase activity", Biochemical Pharmacology, 7, pp.88~95 (1961)
- Gorelick PB., "Stroke prevention therapy beyond antithrombotics : unifying mechanisms in ischemic stroke pathogenesis and implications for therapy : An invited review", Stroke, 33, pp.862~875 (2002)
- Griffith OW., "Determination of glutathione and glutathione disulfide using glutathionereductase and 2-vinylpyridine", Analytical Biochemistry, 106, pp.207~212 (1980)
- Hiramatsu M, "Antioxidant and neuroprotective activities of Mogami-benibana(Safflower, Carthamus tinctorius Linne)", Neurochememical Research, 34, pp.795~805 (2009)
- Ishimaru H, "Immunohistochemical and neurochemical studies of hippocampal cholinergic neurones after ischaemia", Neuroreport, 6, pp.557~560 (1995)
- John C., "The mycenaean world", pp.120~ (1976), Cambridge University Press
- Johnston AM, "Oilseed crops for semiarid cropping systems in the northern Great Plains", Agronomy Journal, 94, pp.231~240 (2002)
- Jover T, "Estrogen protects against global ischemia-induced neuronal death and prevents activation of apoptotic signaling cascades in the hippocampal CA1", Journal of Neuroscience, 22, pp.2115~2124 (2002)
- Kang SY, "Decursin from Angelica gigas mitigates amnesia induced by scopolamine in mice", Neurobiology of Learning and Memory, 79, pp.11~18 (2003)
- 김주연, "Protective Effect of Vitis amurensis Stems and Leaves Extract on Hydrogen Peroxide-induced Oxidative Neuronal Cell Damage in Cultured Neurons", 한국약용작물학회지, 17(1), pp.68~74 (2009), 한국약용작물학회
- 김주연, "Protective Effect of an Ethanol Extract Mixture of Curcuma longae Radix, Phellinus linteus, and Scutellariae Radix on Oxidative Neuronal Damage", 한국약용작물학회지, 19(1), pp.31~37 (2011), 한국약용작물학회
- 이승은, "Trimethyltin으로 유도된 기억장애 흰쥐에서 백삼의 신경보호효과", 한국약용작물학회지, 19(6), pp.456~463 (2011), 한국약용작물학회
- Luo J, "Effects of Carthamus tinctorius injection on bcl-2, caspase-3 expression related to neurons apoptosis after local cerebral ischemia", Zhongguo Zhong Yao Za Zhi, 29, pp.977~980 (2004)
- Milner B, "Cognitive neuroscience and the study of memory", Neuron, 20, pp.445~468 (1998)
- Pomponi M, "Present state and future development of the therapy of Alzheimer disease", Aging(Milano), 2, pp.125~153 (1990)
- Pulsinelli WA, "New model of bilateral hemispheric ischemia in the unanesthetized rat", Stroke, 10, pp.267~272 (1979)
- Rhandi S, "Increased choline-containing compounds in the orbitofrontal cortex and hippocampus in euthymic patients with bipolar disorder : A proton magnetic resonance spectroscopy study", Psychiatry Research-Neuroimaging, 172, pp.205~209 (2009)
- Sakuma M, "Time dependent changes of striatal interneurons after focal cerebral ischemia in rats", Journal of Neural Transmission, 115, pp.413~422 (2008)
- Shaw MR, "A history of atmospheric CO2 and its effects on plants, animals, and ecosystems", pp.415~416 (2005), Springer Science and Business Media Inc
- Soma S, "Cholinesterase inhibitor, donepezil, improves visual contrast detectability in freely behaving rats", Behavioural Brain Research, 256, pp.362~367 (2013)
- Song JC, "Examination and isolation of natural antioxidants from Korean medicinal plants", Korean Journal of Medicinal Crop Science, 8, pp.94~101 (2000)
- Sussman JL, "Atomic structure of acetylcholinetserase", Science, 253, pp.872~880 (1991)
- Suzuki K, "Effects of safflower seed extract aon arterial stiffness", Vascular Health and Risk Managenment, 3, pp.1007~1014 (2010)
- Vales K, "Central muscarinic blockade interferes with retrieval and reacquisition of active allothetic place avoidance despite spatial pretraining", Behavioural Brain Research, 16, pp.238~244 (2005)
- Zhu HB, "Therapeutic effects of hydroxysafflor yellow A on focal cerebral ischemic injury in rats and its primary mechanisms", Journal of Asian Natural Products Research, 7, pp.607~613 (2005)