Human Papilloma Virus in Retinoblastoma Tissues from Korean Patients
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Purpose: Recent reports suggest the association of human papilloma virus (HPV) with retinoblastoma. This study was performed to elucidate whether HPV infection is related to retinoblastoma among Koreans. Methods: A total of 54 cases diagnosed with retinoblastoma were enrolled from Seoul National University Children’s Hospital and Seoul Metropolitan Government- Seoul National University Boramae Medical Center. Presence of human papilloma viral DNA was detected by in situ hybridization in formalin-fixed paraffin-embedded retinoblastoma tissues using both probes against high- and low risk HPV types. Results: The mean age at diagnosis was 22.0 months (range, 1.1 to 98.0 months), and the mean age at enucleation was 27.8 months (range, 1.5 to 112.7 months) among the 54 patients with retinoblastoma. HPV was not detected in any of the retinoblastoma samples using either high risk or low risk HPV probes. Conclusions: Our study, being the first study in the Korean population, proposes that HPV infection may have no causal relationship with retinoblastoma in Koreans.
Abstract
Purpose: Recent reports suggest the association of human papilloma virus (HPV) with retinoblastoma. This study was performed to elucidate whether HPV infection is related to retinoblastoma among Koreans. Methods: A total of 54 cases diagnosed with retinoblastoma were enrolled from Seoul National University Children’s Hospital and Seoul Metropolitan Government- Seoul National University Boramae Medical Center. Presence of human papilloma viral DNA was detected by in situ hybridization in formalin-fixed paraffin-embedded retinoblastoma tissues using both probes against high- and low risk HPV types. Results: The mean age at diagnosis was 22.0 months (range, 1.1 to 98.0 months), and the mean age at enucleation was 27.8 months (range, 1.5 to 112.7 months) among the 54 patients with retinoblastoma. HPV was not detected in any of the retinoblastoma samples using either high risk or low risk HPV probes. Conclusions: Our study, being the first study in the Korean population, proposes that HPV infection may have no causal relationship with retinoblastoma in Koreans.
참고문헌 (19)
- Zur Hausen H, "Papillomaviruses causing cancer : evasion from host-cell control in early events in carcinogenesis", J Natl Cancer Inst, 92, pp.690~698 (2000)
- Forman D, "Association between infection with Helicobacter pylori and risk of gastric cancer : evidence from a prospective investigation", BMJ, 302, pp.1302~1305 (1991)
- Choung HK, "Multigene methylation analysis of ocular adnexal MALT lymphoma and their relationship to Chlamydophila psittaci infection and clinical characteristics in South Korea", Invest Ophthalmol Vis Sci, 53, pp.1928~1935 (2012)
- Dimaras H, "Retinoblastoma", Lancet, 379, pp.1436~1446 (2012)
- Anand B, "Prevalence of highrisk human papillomavirus genotypes in retinoblastoma", Br J Ophthalmol, 95, pp.1014~1018 (2011)
- Shetty OA, "Evidence for the presence of high risk human papillomavirus in retinoblastoma tissue from nonfamilial retinoblastoma in developing countries", Pediatr Blood Cancer, 58, pp.185~190 (2012)
- Gillison ML, "Human retinoblastoma is not caused by known pRb-inactivating human DNA tumor viruses", Int J Cancer, 120, pp.1482~1490 (2007)
- Mohan A, "Detection of human papillomavirus DNA in retinoblastoma samples : a preliminary study", J Pediatr Hematol Oncol, 31, pp.8~13 (2009)
- Antoneli CB, "Low prevalence of HPV in Brazilian children with retinoblastoma", J Med Virol, 83, pp.115~118 (2011)
- Palazzi MA, "Detection of oncogenic human papillomavirus in sporadic retinoblastoma", Acta Ophthalmol Scand, 81, pp.396~398 (2003)
- 이은희, "Prevalence and Distribution of Human Papillomavirus Infection in Korean Women as Determined by Restriction Fragment Mass Polymorphism Assay", Journal of Korean Medical Science, 27(9), pp.1091~1097 (2012), 대한의학회
- Deodhar K, "Prevalence of human papillomavirus types in cervical lesions from women in rural Western India", J Med Virol 2012, 84, pp.1054~1060 (2012)
- Vinodhini K, "Prevalence of high-risk HPV and associated risk factors in cases of cervical carcinoma in Tamil Nadu, India", Int J Gynaecol Obstet, 119, pp.253~256 (2012)
- Schlecht NF, "A comparison of clinically utilized human papillomavirus detection methods in head and neck cancer", Mod Pathol, 24, pp.1295~1305 (2011)
- 정은선, "자궁경부 상피내병변에서 사람유두종바이러스 제자리부합법 및 L1 피각단백 면역조직화학염색의 임상적 유용성", Obstetrics & Gynecology Science, 52(12), pp.1279~1286 (2009), 대한산부인과학회
- Jordan RC, "Validation of methods for oropharyngeal cancer HPV status determination in US cooperative group trials", Am J Surg Pathol, 36, pp.945~954 (2012)
- Zur Hausen H, "Immortalization of human cells and their malignant conversion by high risk human papillomavirus genotypes", Semin Cancer Biol, 9, pp.405~411 (1999)
- Venuti A, "HPV detection methods in head and neck cancer", Head Neck Pathol, 6(1), pp.63~74 (2012)
- Rayess H, "Cellular senescence and tumor suppressor gene p16", Int J Cancer, 130, pp.1715~1725 (2012)