Development of New Solitary Retinoblastoma Tumors during and after Chemotherapy
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Purpose: To review the occurrence of new solitary tumors during and after intravenous chemotherapy against retinoblastoma. Methods: From 115 eyes of 78 patients with a diagnosis of intraocular retinoblastoma who underwent intravenous chemotherapyand focal treatment without prior treatment, patient demographics, age at diagnosis, laterality, classification(Reese-Ellsworth and International Classification of Retinoblastoma), and treatment options were recorded. In addition, theoccurrence of small tumors during and after chemotherapy was documented with a detailed review of medical records andfundus photographs. Results: Of a total of 115 eyes of 78 consecutive patients, new solitary tumors were observed in 50 eyes (50 / 115, 43%) of40 patients (40 / 78, 51%). Multinominal logistic regression analyses showed that age at diagnosis (before 1 year) and vitrealseeding at diagnosis were linked to the development of isolated and miliary tumors, respectively. Kaplan-Meier analysesdemonstrated that all small tumors developed with 20 months from the start of chemotherapy. Twenty-eight eyes (28 / 34,82%) were salvaged with additional focal treatment in 34 eyes with isolated tumors. Conclusions: Small tumors were observed during and after chemotherapy against retinoblastoma in patients who underwentintravenous chemotherapy and focal treatment. It is necessary to promptly identify and address small tumors for thepreservation of eyeball and vision.
Abstract
Purpose: To review the occurrence of new solitary tumors during and after intravenous chemotherapy against retinoblastoma. Methods: From 115 eyes of 78 patients with a diagnosis of intraocular retinoblastoma who underwent intravenous chemotherapyand focal treatment without prior treatment, patient demographics, age at diagnosis, laterality, classification(Reese-Ellsworth and International Classification of Retinoblastoma), and treatment options were recorded. In addition, theoccurrence of small tumors during and after chemotherapy was documented with a detailed review of medical records andfundus photographs. Results: Of a total of 115 eyes of 78 consecutive patients, new solitary tumors were observed in 50 eyes (50 / 115, 43%) of40 patients (40 / 78, 51%). Multinominal logistic regression analyses showed that age at diagnosis (before 1 year) and vitrealseeding at diagnosis were linked to the development of isolated and miliary tumors, respectively. Kaplan-Meier analysesdemonstrated that all small tumors developed with 20 months from the start of chemotherapy. Twenty-eight eyes (28 / 34,82%) were salvaged with additional focal treatment in 34 eyes with isolated tumors. Conclusions: Small tumors were observed during and after chemotherapy against retinoblastoma in patients who underwentintravenous chemotherapy and focal treatment. It is necessary to promptly identify and address small tumors for thepreservation of eyeball and vision.
참고문헌 (9)
- 신주영, "Eye-Preserving Therapy in Retinoblastoma: Prolonged Primary Chemotherapy Alone or Combined with Local Therapy", Korean Journal of Ophthalmology, 24(4), pp.219~224 (2010), 대한안과학회
- Dimaras H, "Retinoblastoma", Nat Rev Dis Primers, 1, pp.15021~ (2015)
- Abramson DH, "Treatment of retinoblastoma in 2015: agreement and disagreement", JAMA Ophthalmol, 133, pp.1341~1347 (2015)
- Messmer EP, "New and recurrent tumor foci following local treatment as well as external beam radiation in eyes of patients with hereditary retinoblastoma", Graefes Arch Clin Exp Ophthalmol, 228, pp.426~431 (1990)
- Schueler AO, "De novo intraocular retinoblastoma development after chemotherapy in patients with hereditary retinoblastoma", Retina, 26, pp.425~431 (2006)
- Shields CL, "Development of new retinoblastomas after 6 cycles of chemoreduction for retinoblastoma in 162 eyes of 106 consecutive patients", Arch Ophthalmol, 121, pp.1571~1576 (2003)
- Murphree AL, "Chemotherapy plus local treatment in the management of intraocular retinoblastoma", Arch Ophthalmol, 114, pp.1348~1356 (1996)
- 김혜리, "Clinical Results of Chemotherapy based Treatment in Retinoblastoma Patients: A Single Center Experience", Cancer Research and Treatment, 40(4), pp.164~171 (2008), 대한암학회
- Abramson DH, "The topography of bilateral retinoblastoma lesions", Retina, 16, pp.232~239 (1996)