항암화학요법과 한방치료를 병행하여 치료한 하인두암 환자 1례
A Case Report of Hypopharyngeal Cancer Improved with Chemotherapy and Korean Medicine Therapy
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This study examined the clinical effects of Korean medicine therapy in a patient with hypopharyngeal cancer treated with chemotherapy. A 53-year-old male patient suffering from hypopharyngeal cancer was treated with docetaxel as well as acupuncture and herbal medicine. Tumor size was measured by computed tomography (CT) and adverse events were evaluated according to the National Cancer Institute's Common Terminology Criteria for Adverse Events (NCI-CTCAE) version 5.0. After two months of combined treatment, the size of the tumor mass was reduced at the left side of the neck, posterior to the CCA and at the lymph node in the left retropharyngeal area and medial aspect of the carotid sheath. The adverse events of chemotherapy also improved. This study indicates that Korean medicine therapy, such as acupuncture and herbal medicine, may lessen the side effects of chemotherapy and may be effective in the treatment of hypopharyngeal cancer.
Abstract
This study examined the clinical effects of Korean medicine therapy in a patient with hypopharyngeal cancer treated with chemotherapy. A 53-year-old male patient suffering from hypopharyngeal cancer was treated with docetaxel as well as acupuncture and herbal medicine. Tumor size was measured by computed tomography (CT) and adverse events were evaluated according to the National Cancer Institute's Common Terminology Criteria for Adverse Events (NCI-CTCAE) version 5.0. After two months of combined treatment, the size of the tumor mass was reduced at the left side of the neck, posterior to the CCA and at the lymph node in the left retropharyngeal area and medial aspect of the carotid sheath. The adverse events of chemotherapy also improved. This study indicates that Korean medicine therapy, such as acupuncture and herbal medicine, may lessen the side effects of chemotherapy and may be effective in the treatment of hypopharyngeal cancer.
참고문헌 (28)
- Annual report of cancer statistics in Korea in 2018, "Korea Central Cancer Registry", Ministry of Health and Welfare, ~ (2020)
- Persky MS, "Combined therapy vs curative radiation in the treatment of pyriform sinus carcinoma", Otolaryngol Head Neck Surg, 89(1), pp.87~91 (1981)
- Pingree TF, "Treatment of hypopharyngeal carcinoma : a 10-year review of 1, 362 cases", Laryngoscope, 97(8Pt 1), pp.901~904 (1987)
- Spaulding MB, "Preoperative chemotherapy for hypopharyngeal carcinoma", Laryngoscope, 93(3), pp.346~349 (1983)
- de GraeffA, "Long-term quality of life of patients with head and neck cancer", Laryngoscope, 110(1), pp.98~106 (2000)
- Garneau JC, "Hypopharyngeal cancer : A state of the art review", Oral Oncol, 86, pp.244~250 (2018)
- Xiao D, "Efficacy of Tongguan Liyan Decoction on pharyngeal cancer-induced dysphagia", All Life, 14(1), pp.159~171 (2021)
- Ben-Arie E, "Digestion-Specific Acupuncture Effect on Feeding Intolerance in Critically Ill Post-Operative Oral and Hypopharyngeal Cancer Patients : A Single-Blind Randomized Control Trial", Nutrients, 13(6), pp.2110~ (2021)
- Eisenhauer EA, "New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1)", Eur J Cancer, 45(2), pp.228~247 (2009)
- "Common Terminology Criteria for Adverse Events(CTCAE) v.5.0" (2017)[URL]
- National Comprehensive Cancer Network, "NCCN Guidelines for Patients-Head and Neck Cancers", ~ (2021)
- Avinçsal MO, "Impact of alcohol dehydrogenase-aldehyde dehydrogenase polymorphism on clinical outcome in patients with hypopharyngeal cancer", Head Neck, 40(4), pp.770~777 (2018)
- 태경, "하인두암의 치료성적: 수술 또는 기관보존요법", 대한이비인후-두경부외과학회지, 52(8), pp.688~694 (2009), 대한이비인후과학회
- Catimel G, "Docetaxel (Taxotere):an active drug for the treatment of patients with advanced squamous cell carcinoma of the head and neck. EORTC Early Clinical Trials Group", Ann Oncol, 5(6), pp.533~537 (1994)
- Vermorken JB, "Lefebvre JL; EORTC 24971", TAX 323 Study Group. Cisplatin, fluorouracil, and docetaxel in unresectable head and neck cancer, 2007, pp.357(17), 1695~1704
- Posner MR, "Cisplatin and fluorouracil alone or with docetaxel in head and neck cancer", N Engl J Med, 357(17), pp.1705~1715 (2007)
- Huang CC, "Acupuncture Relieved Chemotherapy-Induced Peripheral Neuropathy in Patients with Breast Cancer : A Pilot Randomized Sham-Controlled Trial", J Clin Med, 10(16), pp.3694~ (2021)
- Lin HC, "The use of adjunctive traditional Chinese medicine therapy and survival outcome in patients with head and neck cancer : a nationwide population-based cohort study", QJM, 108(12), pp.959~965 (2015)
- 許浚, "東醫寶鑑", pp.1433~ (1999), 법인문화사
- Kang PG, "Effects of Several Medicine Herb Prescriptions on Lung Carcinoma Cells", Journal of Korean Oriental Internal Medicine, 21(4), pp.621~631 (2000)
- Lee JH, "Experimental studies on antitumor effects and immune responses of Gylkyungtang and Gylkyungtanggamibang", Kyung Hee Unicersity Oriental Medical Journal, 21(1), pp.225~250 (1998)
- Ko YC, "Study on Anticancer Mechanism of Gilkyeung-Tang in Lung Cancer Cells", The Journal of the Korea institute of oriental medical informatics, 9(2), pp.94~113 (2003)
- 한인선, "항암제로 유발된 백혈구감소증 회복에 미치는 황기의 효과", 대한한방내과학회지, 27(3), pp.579~588 (2006), 대한한방내과학회
- Hsieh CH, "Incorporation of Astragalus polysaccharides injection during concurrent chemoradiotherapy in advanced pharyngeal or laryngeal squamous cell carcinoma : preliminary experience of a phase II double-blind, randomized trial", J Cancer Res Clin Oncol, 146(1), pp.33~41 (2020)
- Song BK, "Effects of Herbs on the Immune Responses", Korean Oriental Medical Society, 18(2), pp.43~57 (1997)
- Park SE, "Induction of apoptosis and inhibition of telomerase activity in human lung carcinoma cells by the water extract of Cordyceps militaris", Food Chem Toxicol, 47(7), pp.1667~1675 (2009)
- 이병욱, "『外臺秘要』의 熏法과 芳香療法에 관한 연구", 대한한의학원전학회지, 18(3), pp.116~125 (2005), 대한한의학원전학회
- Zhang DY, "Inhibition of cancer cell proliferation and prostaglandin E2 synthesis by Scutellaria baicalensis", Cancer Res, 63(14), pp.4037~4043 (2003)