Colistin Resistance in Escherichia coli Isolates From Patients With Bloodstream Infection in Korea
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Dear Editor, Colistin is the last line of defense for carbapenem-resistant Enterobacteriaceae (CRE) or Acinetobacter baumannii infection [1]. Recently, a plasmid-mediated colistin resistance mechanism (mcr-1 gene) was identified in human, animal, and environmental isolates in China, and the worldwide spread of the mcr-1 gene has continuously been reported [2]. This colistin resistance mechanism has mainly been found in isolates linked to community-associated infections or from animals [2]. However, mcr-1-encoding plasmid-mediated colistin-resistant Escherichia coli isolates were detected in a Danish patient with a bloodstream infection [3]. This possibility raises major public health concern for the emerging threats of CRE, given the limited therapeutic options, clinical severity, and poor outcomes. The aim of this study was to evaluate the recent epidemiology of colistin resistance in bloodstream E. coli, including mcr-1-mediated colistin resistance in Korea.
Abstract
Dear Editor, Colistin is the last line of defense for carbapenem-resistant Enterobacteriaceae (CRE) or Acinetobacter baumannii infection [1]. Recently, a plasmid-mediated colistin resistance mechanism (mcr-1 gene) was identified in human, animal, and environmental isolates in China, and the worldwide spread of the mcr-1 gene has continuously been reported [2]. This colistin resistance mechanism has mainly been found in isolates linked to community-associated infections or from animals [2]. However, mcr-1-encoding plasmid-mediated colistin-resistant Escherichia coli isolates were detected in a Danish patient with a bloodstream infection [3]. This possibility raises major public health concern for the emerging threats of CRE, given the limited therapeutic options, clinical severity, and poor outcomes. The aim of this study was to evaluate the recent epidemiology of colistin resistance in bloodstream E. coli, including mcr-1-mediated colistin resistance in Korea.
참고문헌 (6)
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