Cut-Off Values for Visceral Fat Area Identifying Korean Adults at Risk for Metabolic Syndrome
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참고문헌
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초록
Background: Cut-off values for visceral fat area (VFA) measured by computed tomography (CT) for identifying individualsat risk of metabolic syndrome (MetS) have not been clearly established in Korean adults, particularly forlarge populations. We aimed to identify optimal VFA and waist circumference (WC) cut-off values and compare theability of VFA and WC to predict the presence of ≥2 metabolic risk factors. Methods: We included 36,783 subjects aged 19–79 years undergoing abdominal fat CT during regular health checkupsbetween January 2007 and February 2015 in Seoul. The risk factors for MetS except WC were based on the InternationalDiabetes Federation criteria. Receiver operating characteristic curve analyses were used to determinethe appropriate VFA and WC cut-off values for MetS. Results: VFA was a more significant predictor of metabolic risk factors than WC and body mass index (BMI). Theoptimal cut-off values for VFA and WC were 134.6 cm2 and 88 cm for men and 91.1 cm2 and 81 cm for women, respectively. We estimated age-specific cut-off values for VFA, WC, and BMI. VFA cut-off values increased with age,particularly among women. Conclusion: This large population study proposed the cut-off values for VFA and WC for identifying subjects at riskof MetS among Korean adults. For more accurate diagnosis, different age-specific cut-off values for VFA and WCmay be considered.
Abstract
Background: Cut-off values for visceral fat area (VFA) measured by computed tomography (CT) for identifying individualsat risk of metabolic syndrome (MetS) have not been clearly established in Korean adults, particularly forlarge populations. We aimed to identify optimal VFA and waist circumference (WC) cut-off values and compare theability of VFA and WC to predict the presence of ≥2 metabolic risk factors. Methods: We included 36,783 subjects aged 19–79 years undergoing abdominal fat CT during regular health checkupsbetween January 2007 and February 2015 in Seoul. The risk factors for MetS except WC were based on the InternationalDiabetes Federation criteria. Receiver operating characteristic curve analyses were used to determinethe appropriate VFA and WC cut-off values for MetS. Results: VFA was a more significant predictor of metabolic risk factors than WC and body mass index (BMI). Theoptimal cut-off values for VFA and WC were 134.6 cm2 and 88 cm for men and 91.1 cm2 and 81 cm for women, respectively. We estimated age-specific cut-off values for VFA, WC, and BMI. VFA cut-off values increased with age,particularly among women. Conclusion: This large population study proposed the cut-off values for VFA and WC for identifying subjects at riskof MetS among Korean adults. For more accurate diagnosis, different age-specific cut-off values for VFA and WCmay be considered.
참고문헌 (28)
- Alberti KG, "Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity", Circulation, 120, pp.1640~1645 (2009)[DOI]
- Kaur J, "A comprehensive review on metabolic syndrome", Cardiol Res Pract, 2014, pp.943162~ (2014)
- Lorenzo C, "The National Cholesterol Education Program-Adult Treatment Panel III, International Diabetes Federation, and World Health Organization definitions of the metabolic syndrome as predictors of incident cardiovascular disease and diabetes", Diabetes Care, 30, pp.8~13 (2007)[DOI]
- Laaksonen DE, "Metabolic syndrome and development of diabetes mellitus: application and validation of recently suggested definitions of the metabolic syndrome in a prospective cohort study", Am J Epidemiol, 156, pp.1070~1077 (2002)[DOI]
- McKeigue PM, "Relation of central obesity and insulin resistance with high diabetes prevalence and cardiovascular risk in South Asians", Lancet, 337, pp.382~386 (1991)[DOI]
- Ascaso JF, "Abdominal obesity, insulin resistance, and metabolic syndrome in a southern European population", Eur J Intern Med, 14, pp.101~106 (2003)[DOI]
- Assmann G, "Harmonizing the definition of the metabolic syndrome: comparison of the criteria of the Adult Treatment Panel III and the International Diabetes Federation in United States American and European populations", Am J Cardiol, 99, pp.541~548 (2007)[DOI]
- Alberti KG, "Metabolic syndrome: a new world-wide definition: a consensus statement from the International Diabetes Federation", Diabet Med, 23, pp.469~480 (2006)[DOI]
- Oh JY, "Prevalence and factor analysis of metabolic syndrome in an urban Korean population", Diabetes Care, 27, pp.2027~2032 (2004)[DOI]
- Lim S, "Increasing prevalence of metabolic syndrome in Korea: the Korean National Health and Nutrition Examination Survey for 1998-2007", Diabetes Care, 34, pp.1323~1328 (2011)[DOI]
- Lee SY, "Appropriate waist circumference cutoff points for central obesity in Korean adults", Diabetes Res Clin Pract, 75, pp.72~80 (2007)[DOI]
- Carey DG, "Abdominal fat and insulin resistance in normal and overweight women: direct measurements reveal a strong relationship in subjects at both low and high risk of NIDDM", Diabetes, 45, pp.633~638 (1996)[DOI]
- Brochu M, "Visceral adipose tissue is an independent correlate of glucose disposal in older obese postmenopausal women", J Clin Endocrinol Metab, 85, pp.2378~2384 (2000)
- Ross R, "Quantification of adipose tissue by MRI: relationship with anthropometric variables", J Appl Physiol (1985), 72, pp.787~795 (1992)[DOI]
- Seo JA, "The cutoff values of visceral fat area and waist circumference for identifying subjects at risk for metabolic syndrome in elderly Korean: Ansan Geriatric (AGE) cohort study", BMC Public Health, 9, pp.443~ (2009)[DOI]
- Lim S, "Optimal cut points of waist circumference (WC) and visceral fat area (VFA) predicting for metabolic syndrome (MetS) in elderly population in the Korean Longitudinal Study on Health and Aging (KLoSHA)", Arch Gerontol Geriatr, 54, pp.e29~e34 (2012)[DOI]
- Borkan GA, "Assessment of abdominal fat content by computed tomography", Am J Clin Nutr, 36, pp.172~177 (1982)[DOI]
- Kvist H, "Total and visceral adipose-tissue volumes derived from measurements with computed tomography in adult men and women: predictive equations", Am J Clin Nutr, 48, pp.1351~1361 (1988)[DOI]
- Goodpaster BH, "Measuring body fat distribution and content in humans", Curr Opin Clin Nutr Metab Care, 5, pp.481~487 (2002)[DOI]
- Fluss R, "Estimation of the Youden Index and its associated cutoff point", Biom J, 47, pp.458~472 (2005)[DOI]
- Han JH, "Visceral adipose tissue as a predictor for metabolic risk factors in the Korean population", Diabet Med, 25, pp.106~110 (2008)
- Tran BT, "The prevalence trend of metabolic syndrome and its components and risk factors in Korean adults: results from the Korean National Health and Nutrition Examination Survey 2008-2013", BMC Public Health, 17, pp.71~ (2017)[DOI]
- 김홍일, "Gender Differences in Diagnostic Values of Visceral Fat Area and Waist Circumference for Predicting Metabolic Syndrome in Koreans", Journal of Korean Medical Science, 26(7), pp.906~913 (2011), 대한의학회
- Examination Committee of Criteria for 'Obesity Disease' in Japan, "New criteria for 'obesity disease' in Japan", Circ J, 66, pp.987~992 (2002)[DOI]
- Oka R, "Reassessment of the cutoff values of waist circumference and visceral fat area for identifying Japanese subjects at risk for the metabolic syndrome", Diabetes Res Clin Pract, 79, pp.474~481 (2008)[DOI]
- Oreopoulos A, "The obesity paradox in the elderly: potential mechanisms and clinical implications", Clin Geriatr Med, 25, pp.643~659 (2009)[DOI]
- Hayashi T, "Minimum waist and visceral fat values for identifying Japanese Americans at risk for the metabolic syndrome", Diabetes Care, 30, pp.120~127 (2007)[DOI]
- Yumi M, "Visceral fat area cutoff for the detection of multiple risk factors of metabolic syndrome in Japanese: the Hitachi Health Study", Obesity (Silver Spring), 20, pp.1744~1749 (2012)[DOI]
