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한국 비만성인의 대사증후군 유병에 따른 내장지방지수와 인슐린저항성, 췌장 베타세포기능과의 관련성

Relationship between Visceral Adiposity Index, Insulin Resistance and Pancreatic Beta Cell Function According to the Prevalence of Metabolic Syndrome in Korean Obese Adults

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키워드

주제분류학제간연구

초록

본 연구는 비만성인을 대상으로 대사증후군 유병에 따라 VAI와 인슐린저항성, 췌장 베타세포기능과의 관련성을 알아보고자 하였다. 2017년 1월부터 2019년 12월까지 분당지역 일개 종합병원에서 건강검진을 받은 만 19세 이상 비만성인 1,797명을 대상으로 분석하였다. 대사증후군은 NCEP-ATP III의 기준에 근거하였다. 인슐린저항성 및 췌장 베타세포기능은 HOMA 지수를 이용하였다. 대조군보다 대사증후군 진단군에서 VAI가 높았으며, 대사증후군 위험요인 개수가 증가할수록 높은 VAI값을 보였다(각각 p<.001). 또한 VAI 사분위수가 증가함에 따라 대사증후군 유병률이 증가하였다(p<.001). VAI는 대조군에서 HOMA-IR 및 HOMA-β와 관련이 있는 것으로 나타났으나, 대사증후군 진단군에서는 HOMA-IR 및 HOMA-β간에 관련이 없었다.

Abstract

The purpose of this study was to investigate the relationship between VAI, insulin resistance, and pancreatic beta cell function according to the prevalence of metabolic syndrome in obese adults. From 2017 to 2019, 1,797 obese adults who received medical checkups at a general hospital in Bundang. Diagnosis of metabolic syndrome is NCEP-ATP III. HOMA index was used for insulin resistance and pancreatic beta cell function. VAI was higher in the metabolic syndrome than in the control(p<.001). As the number of risk factors for metabolic syndrome increased, the VAI value was higher(p<.001). The prevalence of metabolic syndrome increased as the VAI quartile increased(p<.001). VAI was also shown to be related to HOMA-IR and HOMA-β in the control, but not in the metabolic syndrome.

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