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IL-27-induced PD-L1highSca-1+ innate lymphoid cells suppress contact hypersensitivity in an IL-10-dependent manner

정연석|김혁순|Kim Do-Kyun|박영준|Kim Young Mi|Min Keun Young|Jo Min Geun|Choi min Yeong|Lee Dajeong|Park Jeong Won|Park Yeong-Min|Choi Wahn Soo
생화학분자생물학회 (Korean Society Of Biochemistry And Molecular Biology)|2024.12|Experimental and Molecular Medicine|제56권 |pp. 616-629|DOI 10.1038/s12276-024-01187-1

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주제분류생화학

초록

Innate lymphoid cells (ILCs) play an important role in maintaining tissue homeostasis and various inflammatory responses. ILCs are typically classified into three subsets, as is the case for T-cells. Recent studies have reported that IL-10-producing type 2 ILCs (ILC210s) have an immunoregulatory function dependent on IL-10. However, the surface markers of ILC210s and the role of ILC210s in contact hypersensitivity (CHS) are largely unknown. Our study revealed that splenic ILC210s are extensively included in PD-L1highSca-1+ ILCs and that IL-27 amplifies the development of PD-L1highSca-1+ ILCs and ILC210s. Adoptive transfer of PD-L1highSca-1+ ILCs suppressed oxazolone-induced CHS in an IL-10-dependent manner Taken together, our results demonstrate that ILC210s are critical for the control of CHS and suggest that ILC210s can be used as target cells for the treatment of CHS.

Abstract

Innate lymphoid cells (ILCs) play an important role in maintaining tissue homeostasis and various inflammatory responses. ILCs are typically classified into three subsets, as is the case for T-cells. Recent studies have reported that IL-10-producing type 2 ILCs (ILC210s) have an immunoregulatory function dependent on IL-10. However, the surface markers of ILC210s and the role of ILC210s in contact hypersensitivity (CHS) are largely unknown. Our study revealed that splenic ILC210s are extensively included in PD-L1highSca-1+ ILCs and that IL-27 amplifies the development of PD-L1highSca-1+ ILCs and ILC210s. Adoptive transfer of PD-L1highSca-1+ ILCs suppressed oxazolone-induced CHS in an IL-10-dependent manner Taken together, our results demonstrate that ILC210s are critical for the control of CHS and suggest that ILC210s can be used as target cells for the treatment of CHS.

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A novel IL-10-producing innate lymphoid cells (ILC10) in a contact hypersensitivity mouse model김영미, 김혁순, 박영민, 이민범, 장종화, 정인덕, 최완수생화학분자생물학회 · BMB Reports2016 · 제49권 제5호Versatile roles of innate lymphoid cells at the mucosal barrier: from homeostasis to pathological inflammation김혜영, Kim Jinwoo, Lim MinYeong, Ryu Seungwon생화학분자생물학회 · Experimental and Molecular Medicine2023 · 제55권 Heterogeneity of IL-22-producing Lymphoid Tissue Inducer-like Cells in Human and Mouse김미연, 김수찬, 한신석대한면역학회 · Immune Network2010 · 제10권 제4호알레르기질환에서의 Type 2 Innate Lymphoid Cell의 역할모지훈대한천식알레르기학회 · 천식 및 알레르기2012 · 제32권 제4호Bone Marrow Progenitors and IL-2 Signaling Contribute to the Strain Differences of Kidney Innate Lymphoid Cells김혜영, Ryu Seungwon대한면역학회 · Immune Network2023 · 제23권 제2호The modulation of pulmonary group 2 innate lymphoid cell function in asthma: from inflammatory mediators to environmental and metabolic factorsChang Ya-Jen, Thio Christina Li-Ping생화학분자생물학회 · Experimental and Molecular Medicine2023 · 제55권

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