알레르기질환에서의 Type 2 Innate Lymphoid Cell의 역할
The Role of Type 2 Innate Lymphoid Cells in Allergic Diseases
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Innate lymphoid cells have recently been identified to be a cell population that has morphology typical of lymphocytes but lacks rearranged antigen receptors. It can be classified into RORγt innate lymphoid cell, type 2 innate lymphoid cells and natual killer cells. Among them, type 2 innate lymphoid cells plays an important role in type 2 immunity by releasing type 2 cytokines, such as interleukin-5 and interleukin-13, and makes a match for Th2 cell of the adaptive immune system. Type 2 innate lymphoid cells responses are initiated by interleukin-25 and interleukin-33, which are produced by several cell types, such as epithelial cells, tissue macrophages and dendritic cells. These cytokines strongly activate type 2 innate lymphoid cells, leading to the production of type 2 cytokines, including, interleukin-5 and interleukin-13. In this review, we will discuss the characteristics and development of type 2 innate lymphoid cells and the role of type 2 innate lymphoid cells in allergic diseases in detail.
Abstract
Innate lymphoid cells have recently been identified to be a cell population that has morphology typical of lymphocytes but lacks rearranged antigen receptors. It can be classified into RORγt innate lymphoid cell, type 2 innate lymphoid cells and natual killer cells. Among them, type 2 innate lymphoid cells plays an important role in type 2 immunity by releasing type 2 cytokines, such as interleukin-5 and interleukin-13, and makes a match for Th2 cell of the adaptive immune system. Type 2 innate lymphoid cells responses are initiated by interleukin-25 and interleukin-33, which are produced by several cell types, such as epithelial cells, tissue macrophages and dendritic cells. These cytokines strongly activate type 2 innate lymphoid cells, leading to the production of type 2 cytokines, including, interleukin-5 and interleukin-13. In this review, we will discuss the characteristics and development of type 2 innate lymphoid cells and the role of type 2 innate lymphoid cells in allergic diseases in detail.
참고문헌 (35)
- Spits H, "The expanding family of innate lymphoid cells: regulators and effectors of immunity and tissue remodeling", Nat Immunol, 12, pp.21~27 (2011)
- Vivier E, "Interleukin-22-producing innate immune cells: new players in mucosal immunity and tissue repair?", Nat Rev Immunol, 9, pp.229~234 (2009)
- Cella M, "A human natural killer cell subset provides an innate source of IL-22 for mucosal immunity", Nature, 457, pp.722~725 (2009)
- Crellin NK, "Regulation of cytokine secretion in human CD127(+) LTi-like innate lymphoid cells by Toll-like receptor 2", Immunity, 33, pp.752~764 (2010)
- Takatori H, "Lymphoid tissue inducer-like cells are an innate source of IL-17 and IL-22", J Exp Med, 206, pp.35~41 (2009)
- Paul WE, "How are T(H)2-type immune responses initiated and amplified?", Nat Rev Immunol, 10, pp.225~235 (2010)
- Saenz SA, "IL25 elicits a multipotent progenitor cell population that promotes T(H)2 cytokine responses", Nature, 464, pp.1362~1366 (2010)
- Moro K, "Innate production of T(H)2 cytokines by adipose tissue- associated c-Kit(+)Sca-1(+) lymphoid cells", Nature, 463, pp.540~544 (2010)
- Neill DR, "Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity", Nature, 464, pp.1367~1370 (2010)
- Fort MM, "IL-25 induces IL-4, IL-5, and IL-13 and Th2-associated pathologies in vivo", Immunity, 15, pp.985~995 (2001)
- Hurst SD, "New IL-17 family members promote Th1 or Th2 responses in the lung: in vivo function of the novel cytokine IL-25", J Immunol, 169, pp.443~453 (2002)
- Price AE, "Systemically dispersed innate IL-13-expressing cells in type 2 immunity", Proc Natl Acad Sci U S A, 107, pp.11489~11494 (2010)
- Mjösberg JM, "Human IL-25- and IL-33-responsive type 2 innate lymphoid cells are defined by expression of CRTH2 and CD161", Nat Immunol, 12, pp.1055~1062 (2011)
- Yang Q, "Cutting edge: natural helper cells derive from lymphoid progenitors", J Immunol, 187, pp.5505~5509 (2011)
- Halim TY, "Retinoic-acid-receptor-related orphan nuclear receptor alpha is required for natural helper cell development and allergic inflammation", Immunity, 37, pp.463~474 (2012)
- Mjösberg J, "Transcriptional control of innate lymphoid cells", Eur J Immunol, 42, pp.1916~1923 (2012)
- Wong SH, "Transcription factor RORα is critical for nuocyte development", Nat Immunol, 13, pp.229~236 (2012)
- Dong C, "Cutting edge: critical role of inducible costimulator in germinal center reactions", J Immunol, 166, pp.3659~3662 (2001)
- Barlow JL, "Innate IL-13-producing nuocytes arise during allergic lung inflammation and contribute to airways hyperreactivity", J Allergy Clin Immunol, 129, pp.191~198 (2012)
- Monticelli LA, "Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus", Nat Immunol, 12, pp.1045~1054 (2011)
- Chang YJ, "Innate lymphoid cells mediate influenza-induced airway hyper-reactivity independently of adaptive immunity", Nat Immunol, 12, pp.631~638 (2011)
- Bartemes KR, "IL-33-responsive lineage- CD25+ CD44(hi) lymphoid cells mediate innate type 2 immunity and allergic inflammation in the lungs", J Immunol, 188, pp.1503~1513 (2012)
- Oshikawa K, "Elevated soluble ST2 protein levels in sera of patients with asthma with an acute exacerbation", Am J Respir Crit Care Med, 164, pp.277~281 (2001)
- Sakashita M, "Association of serum interleukin-33 level and the interleukin-33 genetic variant with Japanese cedar pollinosis", Clin Exp Allergy, 38, pp.1875~1881 (2008)
- Wang YH, "IL-25 augments type 2 immune responses by enhancing the expansion and functions of TSLP-DC-activated Th2 memory cells", J Exp Med, 204, pp.1837~1847 (2007)
- Corrigan CJ, "Allergen-induced expression of IL-25 and IL-25 receptor in atopic asthmatic airways and late-phase cutaneous responses", J Allergy Clin Immunol, 128, pp.116~124 (2011)
- Halim TY, "Lung natural helper cells are a critical source of Th2 cell-type cytokines in protease allergen-induced airway inflammation", Immunity, 36, pp.451~463 (2012)
- Wilhelm C, "An IL-9 fate reporter demonstrates the induction of an innate IL-9 response in lung inflammation", Nat Immunol, 12, pp.1071~1077 (2011)
- Taube C, "IL-22 is produced by innate lymphoid cells and limits inflammation in allergic airway disease", PLoS One, 6, pp.e21799~ (2011)
- Takahashi K, "IL-22 attenuates IL-25 production by lung epithelial cells and inhibits antigen-induced eosinophilic airway inflammation", J Allergy Clin Immunol, 128, pp.1067~1076 (2011)
- Bartlett NW, "Mouse models of rhinovirus-induced disease and exacerbation of allergic airway inflammation", Nat Med, 14, pp.199~204 (2008)
- Liu X, "Anti-IL-33 antibody treatment inhibits airway inflammation in a murine model of allergic asthma", Biochem Biophys Res Commun, 386, pp.181~185 (2009)
- Ramaprakash H, "Targeting ST2L potentiates CpG-mediated therapeutic effects in a chronic fungal asthma model", Am J Pathol, 179, pp.104~115 (2011)
- Ballantyne SJ, "Blocking IL-25 prevents airway hyperresponsiveness in allergic asthma", J Allergy Clin Immunol, 120, pp.1324~1331 (2007)
- Spits H, "Innate lymphoid cells: emerging insights in development, lineage relationships, and function", Annu Rev Immunol, 30, pp.647~675 (2012)
