Pure Word Deafness in a Patient with Early-Onset Alzheimer’s Disease: An Unusual Presentation
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Background and Purpose The occurrence of PWD in neurodegenerative disease is very rare, and this is the first report of it being related to early-onset AD. We describe a patient with early-onset Alzheimer’s disease (AD) who presented with pure word deafness (PWD). Case Report The patient had experienced PWD for 2 years, followed by other cognitive deficits suggestive of parietotemporal dysfunction. Brain imaging including 18 FDG-PET and [11C] PIBPET supported the diagnosis of AD. Conclusions Our case highlights the clinical variability that characterizes early-onset AD.
Abstract
Background and Purpose The occurrence of PWD in neurodegenerative disease is very rare, and this is the first report of it being related to early-onset AD. We describe a patient with early-onset Alzheimer’s disease (AD) who presented with pure word deafness (PWD). Case Report The patient had experienced PWD for 2 years, followed by other cognitive deficits suggestive of parietotemporal dysfunction. Brain imaging including 18 FDG-PET and [11C] PIBPET supported the diagnosis of AD. Conclusions Our case highlights the clinical variability that characterizes early-onset AD.
참고문헌 (12)
- Coslett HB, "Pure word deafness after bilateral primary auditory cortex infarcts", Neurology, 34, pp.347~352 (1984)
- Denes G, "Auditory modality-specific anomia: evidence from a case of pure word deafness", Cortex, 11, pp.401~411 (1975)
- Iizuka O, "Pure word deafness and pure anarthria in a patient with frontotemporal dementia", Eur J Neurol, 14, pp.473~475 (2007)
- Otsuki M, "Slowly progressive pure word deafness", Eur Neurol, 39, pp.135~140 (1998)
- Seo SW, "Cortical thickness in single- versus multiple-domain amnestic mild cognitive impairment", Neuroimage, 36, pp.289~297 (2007)
- Mesulam MM, "Slowly progressive aphasia without generalized dementia", Ann Neurol, 11, pp.592~598 (1982)
- Kaga K, "Central auditory information processing in patients with bilateral auditory cortex lesions", Acta Otolaryngol Suppl, 532, pp.77~82 (1997)
- Kaga K, "Neuropathology of auditory agnosia following bilateral temporal lobe lesions: a case study", Acta Otolaryngol, 120, pp.259~262 (2000)
- Wirkowski E, "I can hear you yet cannot comprehend: a case of pure word deafness", J Emerg Med, 30, pp.53~55 (2006)
- Hayashi K, "Pure word deafness due to left subcortical lesion: neurophysiological studies of two patients", Clin Neurophysiol, 118, pp.863~868 (2007)
- Vitte E, "Midbrain deafness with normal brainstem auditory evoked potentials", Neurology, 58, pp.970~973 (2002)
- Jäncke L, "Phonetic perception and the temporal cortex", Neuroimage, 15, pp.733~746 (2002)