Posterior Type of Alzheimer’s Dementia Presenting with Homonymous Hemianopsia
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Background Alzheimer’s disease is a chronic neurodegenerative condition, mostly affecting the medial temporal lobe and associated neocortical structures. In this report, we present a rare clinical manifestation of this disease. Case Report A 61-year-old female with word finding difficulty and memory disturbances was diagnosed with Alzheimer’s disease. Two years later, she complained of right homonymous hemianopia without optic ataxia, ocular apraxia, and simultagnosia. No findings other than parenchymal disease were apparent in magnetic resonance imaging and laboratory tests. Conclusions In this case, in a patient initially diagnosed with Alzheimer’s dementia with progressive disease, we found only homonymous hemianopia, without signs of Balint’s syndrome or Gerstmann’s syndrome. After careful investigation showing that Alzheimer’s dementia with visual symptom was not associated with parenchymal disease, we concluded a case of atypical variant of Alzheimer’s disease.
Abstract
Background Alzheimer’s disease is a chronic neurodegenerative condition, mostly affecting the medial temporal lobe and associated neocortical structures. In this report, we present a rare clinical manifestation of this disease. Case Report A 61-year-old female with word finding difficulty and memory disturbances was diagnosed with Alzheimer’s disease. Two years later, she complained of right homonymous hemianopia without optic ataxia, ocular apraxia, and simultagnosia. No findings other than parenchymal disease were apparent in magnetic resonance imaging and laboratory tests. Conclusions In this case, in a patient initially diagnosed with Alzheimer’s dementia with progressive disease, we found only homonymous hemianopia, without signs of Balint’s syndrome or Gerstmann’s syndrome. After careful investigation showing that Alzheimer’s dementia with visual symptom was not associated with parenchymal disease, we concluded a case of atypical variant of Alzheimer’s disease.
참고문헌 (18)
- De-Paula VJ, "Alzheimer’s disease", Subcell Biochem, 65, pp.329~352 (2012)
- Apostolova LG, "Alzheimer disease", Continuum, 22, pp.419~434 (2016)
- Pellegrini F, "Homonymous hemianopsia due to posterior cortical atrophy", Neuroophthalmology, 41, pp.154~158 (2017)
- Ishiwata A, "Homonymous hemianopsia associated with probable Alzheimer’s disease", J Nippon Med Sch, 83, pp.87~92 (2016)
- Benson DF, "Posterior cortical atrophy", Arch Neurol, 45, pp.789~793 (1988)
- Crutch SJ, "Posterior cortical atrophy", Lancet Neurol, 11, pp.170~178 (2012)
- Renner JA, "Progressive posterior cortical dysfunction: a clinicopathologic series", Neurology, 63, pp.1175~1180 (2004)
- Tang-Wai DF, "Clinical, genetic, and neuropathologic characteristics of posterior cortical atrophy", Neurology, 63, pp.1168~1174 (2004)
- Snowden JS, "Cognitive phenotypes in Alzheimer’s disease and genetic risk", Cortex, 43, pp.835~845 (2007)
- Mendez MF, "Posterior cortical atrophy:clinical characteristics and differences compared to Alzheimer’s disease", Dement Geriatr Cogn Disord, 14, pp.33~40 (2002)
- Shea YF, "Visual field defect as an uncommon presentation of posterior cortical atrophy", Geriatr Gerontol Int, 14, pp.1003~1004 (2014)
- Cordano C, "Homonymous hemianopia as the first sign of posterior cortical atrophy", J Neurol Sci, 373, pp.38~40 (2017)
- Wan SL, "Posterior cortical atrophy presenting with superior arcuate field defect", Case Rep Ophthalmol Med, 2015, pp.796381~ (2015)
- Goodwin D, "Homonymous hemianopia: challenges and solutions", Clin Ophthalmol, 8, pp.1919~1927 (2014)
- Auerbach SH, "Pure agraphia and unilateral optic ataxia associated with a left superior parietal lobule lesion", J Neurol Neurosurg Psychiatry, 44, pp.430~432 (1981)
- Perenin MT, "Optic ataxia: a specific disruption in visuomotor mechanisms. I. Different aspects of the deficit in reaching for objects", Brain, 111, pp.643~674 (1988)
- Lee AG, "Neuro-ophthalmic findings in the visual variant of Alzheimer’s disease", Ophthalmology, 111, pp.376~380 (2004)
- Vighetto A, "Towards an earlier diagnosis of Alzheimer’s disease presenting with visuospatial disorders (posterior cortical atrophy)", Rev Neurol, 169, pp.687~694 (2013)