후천성 면역 결핍증 환자에서 조직생검으로 확진된진행성 다발성 백질뇌병증 1예
A Case of Progressive Multifocal Leukoencephalopathy in a Patient withAcquired Immune Deficiency Syndrome
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초록
세포면역결핍 상황에서 병발하는 진행성 다발성 백질뇌병증은 후천성 면역결핍증의 유병률이 증가하면서 그 발생률 또한 같이 증가하고 있다. 진단을 위해서는 임상 양상과 방사선 검사에 추가해서 뇌척수액의 분자생물학적 검사 또는 뇌조직 검사를 시행하여야 한다. 본 예는 뇌생검을 통해 진행성 다발성 백질뇌병증이 확진되었으며 항레트로바이러스 치료 후 양호한 경과를 보였기에 문헌고찰과 함께 보고하는 바이다.
Abstract
In Korea, as the prevalence of acquired immune deficiency syndrome (AIDS) increases, various opportunistic infections are becoming a problem. Progressive multifocal leukoencephalopathy (PML) is postulated to be associated with impaired cellular immunity and can be more frequently encountered these days primarily due to increasing incidence of AIDS. Neurologic deficits and brain imaging study together strongly suggest PML, but confirmatory diagnosis can be made only by cerebrospinal fluid study or tissue biopsy. In Korea few cases of confirmed PML in AIDS patients have been reported, and herein we offer our experience of a case of PML who underwent brain biopsy for confirmative diagnosis.
참고문헌 (14)
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