PCTP: Toxicity, persistence, and safety considerations for potential contamination
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Pentachlorothiophenol (PCTP) is recognized for its toxicological concerns and environmental persistence. As a persistent, bioaccumulative, and toxic substance, PCTP has garnered attention due to its potential adverse impacts on ecosystems and human health. Despite its significance, research on PCTP remains relatively sparse, with limited recent literature available on its toxicity, methods for quantification, and occurrence in environmental matrices. Analytical methods for detecting PCTP have largely evolved from techniques used for similar compounds such as hexachlorobenzene, focusing on metabolite analysis in biological and environmental samples. Recent studies underscore the necessity for robust analytical techniques to precisely monitor PCTP levels in aquatic systems and human exposure scenarios. This review consolidates current knowledge on PCTP, emphasizing its toxicological profile, analytical methodologies, and occurrence in environmental samples. By synthesizing findings from recent studies, this paper offers insights into the current understanding of PCTP while identifying areas that warrant further investigation.
Abstract
Pentachlorothiophenol (PCTP) is recognized for its toxicological concerns and environmental persistence. As a persistent, bioaccumulative, and toxic substance, PCTP has garnered attention due to its potential adverse impacts on ecosystems and human health. Despite its significance, research on PCTP remains relatively sparse, with limited recent literature available on its toxicity, methods for quantification, and occurrence in environmental matrices. Analytical methods for detecting PCTP have largely evolved from techniques used for similar compounds such as hexachlorobenzene, focusing on metabolite analysis in biological and environmental samples. Recent studies underscore the necessity for robust analytical techniques to precisely monitor PCTP levels in aquatic systems and human exposure scenarios. This review consolidates current knowledge on PCTP, emphasizing its toxicological profile, analytical methodologies, and occurrence in environmental samples. By synthesizing findings from recent studies, this paper offers insights into the current understanding of PCTP while identifying areas that warrant further investigation.
참고문헌 (38)
- Agency for Toxic Substances and Disease Registry (ATSDR)., "Toxicological Profile for Hexachlorobenzene. (Draft for Public Comment) U.S", Department of Health and Human Services, Public Health Service, 173~178 (2013)
- Bahig ME, "Metabolism of pentachloronitrobenzene-14C(quintozene)in fish", Chemosphere, 10, pp.319~322 (1981)
- Bauer I, "Biotransformation of hexachlorobenzene in the blue mussel(Mytilus edulis)", Chemosphere, 19, pp.1701~1707 (1989)
- Böger A, "Rat liver alterations after chronic treatment with hexachlorobenzene", Virchows Arch A Path Anat and Histol, 382, pp.127~137 (1979)
- Clayton GD, "Patty’s Industrial Hygiene and Toxicology : Volume 2A, 2B, 2C : Toxicology", pp.3630~3632 (1981), John Wiley Sons
- de Calmanovici RW, "Effect of desferrioxamine on the development of hexachlorobenzene-induced porphyria", Biochem Pharmacol, 35, pp.2399~2405 (1986)
- Debets FMH, "Biotransformation and porphyrinogenic action of hexachlorobenzene and its metabolites in a primary liver cell culture", Toxicology, 19, pp.185~196 (1981)
- Drotar AM, "Characterization of a xenobiotic thiol methyltransferase and its role in detoxication in Tetrahymena thermophila", Pestic Biochem Physiol, 25, pp.396~406 (1986)
- Drotar AM, "Microbial methylation of benzenethiols and release of methylthiobenzenes", Experientia, 41, pp.762~764 (1985)
- Duttagupta S, "Wide exposure of persistent organic pollutants(PoPs)in natural waters and sediments of the densely populated Western Bengal basin, India", Sci Total Environ, 717, pp.137187~ (2020)
- "Persistent, bioaccumulative, and toxic (PBT) chemicals under TSCA section 6(h)"[URL]
- "Hexachlorobenzene substance information"[URL]
- "Pentachlorobenzenethiol substance information"[URL]
- Gallo F, "Marine litter plastics and microplastics and their toxic chemicals components : The need for urgent preventive measures", Environ Sci Eur, 30, pp.13~ (2018)
- Hoondert RPJ, "Implications of trophic variability for modeling biomagnification of POPs in marine food webs in the Svalbard archipelago", Environ Sci Technol, 54, pp.4026~4035 (2020)
- Koss G, "Studies on the toxicology of hexachlorobenzene: II. Identification and determination of metabolites", Arch Toxicol, 35, pp.107~114 (1976)
- Koss G, "Studies on the toxicology of hexachlorobenzene : IV. Sulphur-containing metabolites", Arch Toxicol, 42, pp.19~31 (1979)
- Koss G, "Studies on the toxicology of hexachlorobenzene : III. Observations in a long-term experiment", Arch Toxicol, 40, pp.285~294 (1978)
- Kulka M, "Reactions of hexachlorobenzene with mercaptides", J Org Chem, 24, pp.235~237 (1959)
- Lee CW, "Research on emissions and mitigation of POP’s from combustion sources", Stud Environ Sci, 72, pp.361~378 (1998)
- "Hexachlorobenzene"[URL]
- "Pentachlorothiophenol"[URL]
- Neilson AH, "Environmental Degradation and Transformation of Organic Chemicals" (2007), CRC Press
- Ochs C, "Contamination of aquatic ecosystems by persistent organic pollutants(POPs)originating from landfills in Canada and the United States : A rapid scoping review", Sci Total Environ, 924, pp.171490~ (2024)
- Renner G, "Metabolic studies on pentachloronitrobenzene(PCNB)in rats", Xenobiotica, 10, pp.537~550 (1980)
- Richter E, "Differences in the biotransformation of hexachlorobenzene (HCB) in male and female rats", Chemosphere, 10, pp.779~785 (1981)
- Rizzardini M, "Sex differences in the metabolism of hexachlorobenzene by rats and the development of porphyria in females", Biochem Pharmacol, 31, pp.3543~3548 (1982)
- Samanipour S, "Overlooked persistent and bioaccumulative pollutants in Lake Geneva : their measurement, occurrence, and concentration distribution in the water column and sediments", Ph D, pp.2015
- Smejtek P, "Electrical conductivity, transfer of hydrogen ions in lipid bilayer membranes and uncoupling effect induced by pentachlorobenzenethiol(pentachlorothiophenol)", J Membr Biol, 76, pp.227~234 (1983)
- Smith AG, "Evidence for the active renal secretion of S-pentachlorophenyl-N-acetyl-L-cysteine by female rats", Biochem Pharmacol, 32, pp.3797~3801 (1983)
- Smolders R, "Applicability of non-invasively collected matrices for human biomonitoring", Environ Health, 8, pp.1~10 (2009)
- "Listing of POPs in the Stockholm Convention"[URL]
- Teng Y, "Biodegradation of pentachloronitrobenzene by Cupriavidus sp. YNS-85 and its potential for remediation of contaminated soils", Environ Sci Pollut Res, 24, pp.9538~9547 (2017)
- Testa B, "Novel drug metabolites produced by functionalization reactions : Chemistry and toxicology", Drug Metab Rev, 7, pp.325~369 (1978)
- To-Figueras J, "Excretion of hexachlorobenzene and metabolites in feces in a highly exposed human population", Environ Health Perspect, 108, pp.595~598 (2000)
- To-Figueras J, "Metabolism of hexachlorobenzene in humans : Association between serum levels and urinary metabolites in a highly exposed population", Environ Health Perspect, 105, pp.78~83 (1997)
- Torres RM, "Liquid chromatography study of degradation and metabolism of pentachloronitrobenzene by four soil micromycetes", Chemosphere, 33, pp.683~692 (1996)
- Principles and Methods for the Risk Assessment of Chemicals in Food, "World Health Organization (WHO).", Food and Agriculture Organization (FAO) of the United Nations, World Health Organization (WHO), ~ (2009)