비타민 D 농도와 신생아 조기 패혈증의 연관성에 대한 체계적 문헌고찰 및 메타분석
The Association between Vitamin D Levels and Neonatal Early-onset Sepsis : A Systematic Review and Meta-analysis
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Background: Vitamin D has been associated with sepsis in pediatric and adult patients. The association with neonates is unclear. This systematic review and meta-analysis examined the effect of neonatal and maternal vitamin D levels on neonatal early-onset sepsis. Methods: We searched studies published up to November 2017 in PubMed/Medline, Embase, and the Cochrane Library databases. All studies that reported 25-hydroxyvitamin D levels in neonates with or without early-onset sepsis were included. Meta-analysis was performed using RevMan 5.3 software. Results: Four studies were eligible. The weighted mean difference of 25-hydroxyvitamin D levels in neonates with early-onset sepsis and controls was -7.27 ng/mL (95% confidence interval = -7.62, 6.92). Maternal vitamin D levels in neonates with early-onset sepsis were significantly lower than those in controls (weighted mean difference -7.24 ng/mL, 95% confidence interval -8.45, -6.03). All neonates with early onset sepsis had vitamin D deficiency (25hydroxyvitamin D <20 ng/mL). Conclusion: Lower neonatal and maternal 25-hydroxyvitamin D levels were associated with neonatal early-onset sepsis. Vitamin D supplementation during pregnancy may be helpful to prevent neonatal early-onset sepsis. The effects of vitamin D supplementation on early-onset sepsis in neonates warrant further study.
Abstract
Background: Vitamin D has been associated with sepsis in pediatric and adult patients. The association with neonates is unclear. This systematic review and meta-analysis examined the effect of neonatal and maternal vitamin D levels on neonatal early-onset sepsis. Methods: We searched studies published up to November 2017 in PubMed/Medline, Embase, and the Cochrane Library databases. All studies that reported 25-hydroxyvitamin D levels in neonates with or without early-onset sepsis were included. Meta-analysis was performed using RevMan 5.3 software. Results: Four studies were eligible. The weighted mean difference of 25-hydroxyvitamin D levels in neonates with early-onset sepsis and controls was -7.27 ng/mL (95% confidence interval = -7.62, 6.92). Maternal vitamin D levels in neonates with early-onset sepsis were significantly lower than those in controls (weighted mean difference -7.24 ng/mL, 95% confidence interval -8.45, -6.03). All neonates with early onset sepsis had vitamin D deficiency (25hydroxyvitamin D <20 ng/mL). Conclusion: Lower neonatal and maternal 25-hydroxyvitamin D levels were associated with neonatal early-onset sepsis. Vitamin D supplementation during pregnancy may be helpful to prevent neonatal early-onset sepsis. The effects of vitamin D supplementation on early-onset sepsis in neonates warrant further study.
참고문헌 (31)
- Shane AL, "Neonatal sepsis", Lancet, 390(10104), pp.1770~1780 (2017)
- Lawn JE, "4 million neonatal deaths: when? Where? Why?", Lancet, 365(9462), pp.891~900 (2005)
- Black RE, "Global, regional, and national causes of child mortality in 2008: a systematic analysis", Lancet, 375(9730), pp.1969~1987 (2010)[DOI]
- Santamaria C, "Prenatal vitamin D status and offspring's growth, adiposity and metabolic health: a systematic review and meta-analysis", Br J Nutr, pp.1~10 (2018)
- Upala S, "Significant association between vitamin D deficiency and sepsis: a systematic review and meta-analysis", BMC anesthesiol, 15, pp.84~ (2015)[DOI]
- DeLuca HF, "Overview of general physiologic features and functions of vitamin D", Am J Clin Nutr, 80(6 Suppl), pp.S1689~S1686 (2004)
- Di Rosa M, "Vitamin D3: a helpful immuno-modulator", Immunology, 134(2), pp.123~139 (2011)[DOI]
- Dinlen N, "Association of vitamin D deficiency with acute lower respiratory tract infections in newborns", J Matern Fetal Neonatal Med, 29(6), pp.928~932 (2016)[DOI]
- Cerone JB, "Incidence of respiratory viral infection in infants with respiratory symptoms evaluated for late-onset sepsis", J Perinatol, 37(8), pp.922~926 (2017)[DOI]
- Moher D, "Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement", J Clin Epidemiol, 62(10), pp.1006~1012 (2009)[DOI]
- "The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomized studies in meta-analysis"[URL]
- Wan X, "Estimating the sample mean and standard deviation from the sample size, median, range and", or interquartile range, 2014, pp.14, 135~
- Gamal TS, "Neonatal and Maternal 25-OH Vitamin D Serum Levels in Neonates with Early-Onset Sepsis", Children (Basel, Switzerland), 4(5), pp.37~ (2017)
- Cizmeci MN, "Cord-blood 25-hydroxyvitamin D levels and risk of early-onset neonatal sepsis: a casecontrol study from a tertiary care center in Turkey", Eur J pediatr, 174(6), pp.809~815 (2015)
- Cetinkaya M, "Lower vitamin D levels are associated with increased risk of early-onset neonatal sepsis in term infants", J Perinatol, 35(1), pp.39~45 (2015)[DOI]
- Yang LR, "Relationship between vitamin D deficiency and early-onset neonatal sepsis", Zhongguo dang dai er ke za zhi, 18(9), pp.791~795 (2016)
- Holick MF, "Vitamin D deficiency", N Engl J Med, 357(3), pp.266~281 (2007)
- Palacios C, "Is vitamin D deficiency a major global public health problem?", J Steroid Biochem Mol Biol, 144, pp.138~145 (2014)[DOI]
- Youssef DA, "Antimicrobial implications of vitamin D", Dermatoendocrinol, 3(4), pp.220~229 (2011)[DOI]
- Hewison M, "Vitamin D and the intracrinology of innate immunity", Mol Cell Endocrinol, 321(2), pp.103~111 (2010)
- de Haan K, "Vitamin D deficiency as a risk factor for infection, sepsis and mortality in the critically ill: systematic review and meta-analysis", Crit Care, 18(6), pp.660~ (2014)[DOI]
- Wagner CL, "Prevention of rickets and vitamin D deficiency in infants, children, and adolescents", Pediatrics, 122(5), pp.1142~1152 (2008)[DOI]
- Braegger C, "Vitamin D in the healthy European paediatric population", J Pediatr Gastroenterol Nutr, 56(6), pp.692~701 (2013)[DOI]
- Zhou J, "Preventive Effects of Vitamin D on Seasonal Influenza A in Infants: A Multicenter, Randomized, Open, Controlled Clinical Trial", Pediatr Infect Dis J. (2018)[DOI]
- Fort P, "A Comparison of 3 Vitamin D Dosing Regimens in Extremely Preterm Infants: A Randomized Controlled Trial", J Pediatr, 174, pp.132~138 (2016)[DOI]
- Cekmez F, "Diagnostic value of 25-hydroxyvitamin D level and new cytokines in neonatal sepsis", Eur J Inflamm, 12(2), pp.297~304 (2014)[DOI]
- Birgul Say, "Effects of cord blood vitamin D levels on the risk of neonatal sepsis in premature infants", Clinical and Experimental Pediatrics, 60(8), pp.248~253 (2017), 대한소아청소년과학회
- Anderson DM, "Dietary assessment of maternal vitamin D intake and correlation with maternal and neonatal serum vitamin D concentrations at delivery", J Perinatol, 8(1), pp.46~48 (1988)
- Moukarzel S, "Maternal Vitamin D Status and Infant Infection", Nutrients, 10(2) (2018)
- Christensen N, "Infant Respiratory Tract Infections or Wheeze and Maternal Vitamin D in Pregnancy: A Systematic Review", Pediatr Infect Dis J, 36(4), pp.384~391 (2017)[DOI]