소아 급성 하기도 감염과 Vitamin D 농도의 연관성
Association of Vitamin D Status with Acute Lower Respiratory Infection in Children
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목 적:본 연구에서는 폐렴과 세기관지염으로 입원한 5세 미만의 소아에서 혈액 25(OH)D의 농도를 측정하여 비타민 D와 급성 하기도 감염과의 관련성을 알아보고자 하였다. 방 법:2009년 10월부터 12월까지 삼성창원병원 소아청소년과에 폐렴 또는 세기관지염으로 입원한 5세 미만 환자 74명을 대상으로 혈액에서 25(OH)D를 측정하여 호흡기 증상이 없는 정상 소아 54명의 혈중 25(OH)D농도와 비교하였다결 과:혈중 25(OH)D의 평균값은 환자군에서 28.4± 9.0 ng/mL, 대조군에서 29.1±7.1 ng/mL 로 유의한 차이는 없었다. 환자군을 폐렴환자군과 세기관기염환자군으로 나누어 25(OH)D 농도를 비교하였을 때도 각각 28.1±8.3 ng/mL, 28.8±9.6 ng/mL으로 유의한 차이가 없었다. 25(OH)D가 결핍농도인 15 ng/mL 이하의 비율은 환자군과 대조군에서 각각 8.1%, 5.6%로 유의한 차이가 없었고, 25(OH)D 가 부족농도인 30 ng/mL 이하의 비율도 환자군과 대조군에서 각각 59.5%, 64.8%로 유의한 차이가 없었다. 결 론:급성 하기도 감염으로 입원한 환자에서 혈중 비타민 D의 농도는 대조군과 비교하여 유의한 차이가 없었다.
Abstract
Purpose:Acute lower respiratory tract infection (ALRI) is a common disease in children. Micronutrient deficiencies may increase the risk of ALRI. The aim of this study is to determine the association of vitamin D status with susceptibility to ALRI by comparing serum 25 hydroxy-vitamin D [25(OH)D] levels between a group of young children under 5 years of age with ALRI and healthy children. Methods:Serum 25(OH)D concentrations were measured in patients under 5 years of age admitted to hospital with a diagnosis of pneumonia (n=40) or bronchiolitis (n=34) from October 2009 to December 2009 as well as in healthy patients of similar age without respiratory symptoms (n=54). Serum 25(OH)D concentrations were measured by electrochemileuminescence immunoassay. Results:The mean serum 25(OH)D level were similar between the ALRI and control groups (28.4±9.0 versus 29.1±7.1 ng/mL). There was no significant difference in the prevalence of 25(OH)D insufficiency between the 2 groups at 2 thresholds (for ˂15 ng/mL, 8.1 vs. 5.6%; P=0.19, and for ˂30 ng/mL, 59.5 vs. 64.8%; P=0.75). Conclusion:In our study, no difference was observed in vitamin D levels between the ALRI and control groups. Therefore, Vitamin D status may not be associated with the risk of hospitalization for ALRI in children.
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