A Clinicopathologic Feature and Survival Analysis of Cutaneous Angiosarcoma: A Single Tertiary Center Study
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Background: Cutaneous angiosarcoma, a rare malignant tumor, is associated with high mor- tality and poor prognosis. Objective: This study aimed to analyze the clinicopathologic features of cutaneous angiosar- coma and identify the prognostic factors influencing survival. Methods: Medical records of patients diagnosed with cutaneous angiosarcoma between Janu- ary 1995 and March 2023 were retrospectively reviewed. Demographic data, clinicopathologic features, and treatment modalities were analyzed to evaluate the correlation with overall sur- vival (OS) and progression-free survival (PFS). A total of 70 patients were included in the study. Results: Their mean age at diagnosis was 71 years (range, 41–91 years). Of them, 57 (81.4%) were males. Five-year OS and PFS rates were 29.0% and 10.7%, respectively. In univariate analysis, a mass in the frontal area of the scalp showed significant associations with poorer PFS (hazard ratio [HR], 1.95; 95% confidence interval [CI], 1.07–3.55; p=0.029) and poorer OS (HR, 2.42; 95% CI, 1.22–4.80; p=0.011). Mass size exceeding 3 cm had a notable impact on PFS (HR, 3.41; 95% CI, 1.32–8.82; p=0.011) and remained a significant independent adverse prognosticator in multivariate analysis (HR, 4.55; 95% CI, 1.22–16.99; p=0.024). Conclusion: Cutaneous angiosarcoma is characterized by an unfavorable prognosis, with a larger mass size identified as an independent prognostic factor.
Abstract
Background: Cutaneous angiosarcoma, a rare malignant tumor, is associated with high mor- tality and poor prognosis. Objective: This study aimed to analyze the clinicopathologic features of cutaneous angiosar- coma and identify the prognostic factors influencing survival. Methods: Medical records of patients diagnosed with cutaneous angiosarcoma between Janu- ary 1995 and March 2023 were retrospectively reviewed. Demographic data, clinicopathologic features, and treatment modalities were analyzed to evaluate the correlation with overall sur- vival (OS) and progression-free survival (PFS). A total of 70 patients were included in the study. Results: Their mean age at diagnosis was 71 years (range, 41–91 years). Of them, 57 (81.4%) were males. Five-year OS and PFS rates were 29.0% and 10.7%, respectively. In univariate analysis, a mass in the frontal area of the scalp showed significant associations with poorer PFS (hazard ratio [HR], 1.95; 95% confidence interval [CI], 1.07–3.55; p=0.029) and poorer OS (HR, 2.42; 95% CI, 1.22–4.80; p=0.011). Mass size exceeding 3 cm had a notable impact on PFS (HR, 3.41; 95% CI, 1.32–8.82; p=0.011) and remained a significant independent adverse prognosticator in multivariate analysis (HR, 4.55; 95% CI, 1.22–16.99; p=0.024). Conclusion: Cutaneous angiosarcoma is characterized by an unfavorable prognosis, with a larger mass size identified as an independent prognostic factor.