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A Common Immunopathogenesis Mechanism for Infectious Diseases: The Protein-Homeostasis-System Hypothesis

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초록

It was once believed that host cell injury in various infectious diseases is caused solely by pathogens themselves; however, itis now known that host immune reactions to the substances from the infectious agents and/or from the injured host cells byinfectious insults are also involved. All biological phenomena in living organisms, including biochemical, physiological andpathological processes, are performed by the proteins that have various sizes and shapes, which in turn are controlled by aninteracting network within the living organisms. The author proposes that this network is controlled by the protein homeostasissystem (PHS), and that the immune system is one part of the PHS of the host. Each immune cell in the host may recognize andrespond to substances, including pathogenic proteins (PPs) that are toxic to target cells of the host, in ways that depend on thesize and property of the PPs. Every infectious disease has its own set of toxic substances, including PPs, associated with diseaseonset, and the PPs and the corresponding immune cells may be responsible for the inflammatory processes that develop inthose infectious diseases.

Abstract

It was once believed that host cell injury in various infectious diseases is caused solely by pathogens themselves; however, itis now known that host immune reactions to the substances from the infectious agents and/or from the injured host cells byinfectious insults are also involved. All biological phenomena in living organisms, including biochemical, physiological andpathological processes, are performed by the proteins that have various sizes and shapes, which in turn are controlled by aninteracting network within the living organisms. The author proposes that this network is controlled by the protein homeostasissystem (PHS), and that the immune system is one part of the PHS of the host. Each immune cell in the host may recognize andrespond to substances, including pathogenic proteins (PPs) that are toxic to target cells of the host, in ways that depend on thesize and property of the PPs. Every infectious disease has its own set of toxic substances, including PPs, associated with diseaseonset, and the PPs and the corresponding immune cells may be responsible for the inflammatory processes that develop inthose infectious diseases.

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