Characteristics of Immunogenicity against SARS-CoV-2 in a Community-Based Model of Care during the Fourth Wave of COVID-19 Outbreak in Ho Chi Minh City
1
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Purpose: Although some immune protection from close contact with individuals who have coronavirus disease 2019 (COVID-19) has been documented, there is limited data on the seroprevalence of antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in individuals who were in lockdown with confirmed COVID-19 cases. This study investigated immunogenicity against SARS-CoV-2 in household members and people who lived near home-quarantined patients with COVID-19. Materials and Methods: This cross-sectional study was conducted during the community-based care that took place during lockdowns in District 10, Ho Chi Minh City, Vietnam from July to September 2021. SARS-CoV-2 antibody levels were determined in index cases of COVID-19, household contacts, and a no-contact group from the same area. Results: A total of 770 participants were included (355 index cases, 103 household contacts, and 312 no contacts). All index cases were unvaccinated, but >90% of individuals in the household and no-contact groups had received ≥1 vaccine dose. SARS-CoV-2 neutralizing antibodies (Nabs) were present in >77% of unvaccinated index cases versus 64%/65.4% in the household/no-contact groups (p=0.001). Antibody concentrations in unvaccinated index cases were significantly higher than those in household contacts and no contacts, with no difference between the latter groups. In all cases, antibody levels declined markedly ≥6 weeks after infection, and failed to persist beyond this time in the household and no-contact groups. Conclusion: Community-based care may have helped to create community immunogenicity, but Nabs did not persist, highlighting a need for vaccination for all individuals before, or from 6 weeks after, infection with SARS-CoV-2.
Abstract
Purpose: Although some immune protection from close contact with individuals who have coronavirus disease 2019 (COVID-19) has been documented, there is limited data on the seroprevalence of antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in individuals who were in lockdown with confirmed COVID-19 cases. This study investigated immunogenicity against SARS-CoV-2 in household members and people who lived near home-quarantined patients with COVID-19. Materials and Methods: This cross-sectional study was conducted during the community-based care that took place during lockdowns in District 10, Ho Chi Minh City, Vietnam from July to September 2021. SARS-CoV-2 antibody levels were determined in index cases of COVID-19, household contacts, and a no-contact group from the same area. Results: A total of 770 participants were included (355 index cases, 103 household contacts, and 312 no contacts). All index cases were unvaccinated, but >90% of individuals in the household and no-contact groups had received ≥1 vaccine dose. SARS-CoV-2 neutralizing antibodies (Nabs) were present in >77% of unvaccinated index cases versus 64%/65.4% in the household/no-contact groups (p=0.001). Antibody concentrations in unvaccinated index cases were significantly higher than those in household contacts and no contacts, with no difference between the latter groups. In all cases, antibody levels declined markedly ≥6 weeks after infection, and failed to persist beyond this time in the household and no-contact groups. Conclusion: Community-based care may have helped to create community immunogenicity, but Nabs did not persist, highlighting a need for vaccination for all individuals before, or from 6 weeks after, infection with SARS-CoV-2.
참고문헌 (23)
- Nguyen TP, "Rapid impact assessments of COVID-19 control measures against the Delta variant and short-term projections of new confirmed cases in Vietnam", J Glob Health, 11, pp.03118~ (2021)
- "Viet Nam-WHO COVID-19 dashboard"[URL]
- Nguyen LTP, "Acceptance and willingness to pay for COVID-19 vaccines available in Vietnam : an online study during the fourth epidemic wave", MedPharmRes, 7, pp.68~75 (2023)
- Vuong LN, "A community-based model of care during the fourth wave of the COVID-19 outbreak in Ho Chi Minh City, Vietnam", Front Artif Intell, 5, pp.831841~ (2022)
- Ye F, "Delivery of infection from asymptomatic carriers of COVID-19 in a familial cluster", Int J Infect Dis, 94, pp.133~138 (2020)
- Dupraz J, "Prevalence of SARS-CoV-2 in household members and other close contacts of COVID-19 cases: a serologic study in canton of Vaud, Switzerland", Open Forum Infect Dis, 8, pp.ofab149~ (2021)
- Nguyen HB, "Knowledge, attitudes, practices, and related factors towards COVID-19 prevention among patients at university medical center Ho Chi Minh City, Vietnam", Risk Manag Healthc Policy, 14, pp.2119~2132 (2021)
- Vo LNQ, "Knowledge, attitudes, and behaviors towards COVID-19 prevention : a cross-sectional study at University Medical Center in Ho Chi Minh City, Vietnam", MedPharmRes, 6, pp.24~33 (2022)
- Huynh G, "Factors relating to preventive practices of health science students during the early stage of the COVID-19 pandemic", Med-PharmRes, 4, pp.27~32 (2020)
- Yao J, "Dynamic changes of antibodies to SARS-CoV-2 in close contacts", J Inflamm Res, 14, pp.4233~4243 (2021)
- Ng OT, "SARSCoV-2 seroprevalence and transmission risk factors among highrisk close contacts : a retrospective cohort study", Lancet Infect Dis, 21, pp.333~343 (2021)
- Yang Y, "SARS-CoV-2 spike protein : a key target for eliciting persistent neutralizing antibodies", Signal Transduct Target Ther, 6, pp.95~ (2021)
- Dogan M, "SARS-CoV-2 specific antibody and neutralization assays reveal the wide range of the humoral immune response to virus", Commun Biol, 4, pp.129~ (2021)
- Dispinseri S, "Neutralizing antibody responses to SARS-CoV-2 in symptomatic COVID-19 is persistent and critical for survival", Nat Commun, 12, pp.2670~ (2021)
- Ishizaki A, "Neutralizing-antibody response to SARS-CoV-2 for 12 months after the COVID-19 workplace outbreaks in Japan", PLoS One, 17, pp.e0273712~ (2022)
- Kaku Y, "Resistance of SARS-CoV-2 variants to neutralization by antibodies induced in convalescent patients with COVID-19", Cell Rep, 36, pp.109385~ (2021)
- Bergwerk M, "Covid-19 breakthrough infections in vaccinated health care workers", N Engl J Med, 385, pp.1474~1484 (2021)
- "Tracking SARS-CoV-2 variants"[URL]
- Lau EHY, "Neutralizing antibody titres in SARS-CoV-2 infections", Nat Commun, 12, pp.63~ (2021)
- Seow J, "Longitudinal observation and decline of neutralizing antibody responses in the three months following SARS-CoV-2 infection in humans", Nat Microbiol, 5, pp.1598~1607 (2020)
- Tang J, "Antibody affinity maturation and plasma IgA associate with clinical outcome in hospitalized COVID-19 patients", Nat Commun, 12, pp.1221~ (2021)
- Trinité B, "SARS-CoV-2 infection elicits a rapid neutralizing antibody response that correlates with disease severity", Sci Rep, 11, pp.2608~ (2021)
- Mahmoud AA, "Neutralizing antibody responses in asymptomatic close contacts of COVID-19 patients and in asymptomatic healthcare workers", Egypt J Immunol, 29, pp.29~35 (2022)