Health-Related Quality of Life in Osteoporosis Patients with and without Fractures in Tehran, Iran
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Background: This study aimed to measure the health-related quality of life (HRQOL) of patients with osteoporosis with and without fractures in Tehran, the capital city of Iran. Methods: We surveyed a sample of 478 patients with osteoporosis aged over 50 years. Participants with fractures included patients referred to hospitals due to osteoporotic fractures which were alive 6 months after the fracture. Participants without fractures were randomly selected from patients with a definite diagnosis of osteoporosis admitted to 3 outpatient clinics in Tehran. Data were collected using the EuroQol 5-dimensional 5-level questionnaire. Statistical differences between patients with and without fracture were tested with Pearson’s χ2 test, Student’s t-test, and the Mann–Whitney U-test. The association between HRQOL and other variables was evaluated using a multiple linear regression model. Results: The patients’ mean age±standard deviation was 67.3±11.9 years, and 74.1% were women. One hundred and seventeen (23%) patients had hip fractures, 56 (11%) had vertebral fractures, 127 (25%) had forearm fractures, and 178 (40%) had no fractures. The median (interquartile range) values of HRQOL scores of those with hip, vertebral, and forearm fractures and those with no history of fracture were 0.53 (0.22), 0.60 (0.28), 0.64 (0.26), and 0.64 (0.27), respectively. The multiple regression model revealed a significant relationship between the HRQOL scores and sex, marital status, employment status, presence of any chronic illness in addition to osteoporosis, and type of fracture. Conclusions: Osteoporosis and its related fractures can reduce the HRQOL.
Abstract
Background: This study aimed to measure the health-related quality of life (HRQOL) of patients with osteoporosis with and without fractures in Tehran, the capital city of Iran. Methods: We surveyed a sample of 478 patients with osteoporosis aged over 50 years. Participants with fractures included patients referred to hospitals due to osteoporotic fractures which were alive 6 months after the fracture. Participants without fractures were randomly selected from patients with a definite diagnosis of osteoporosis admitted to 3 outpatient clinics in Tehran. Data were collected using the EuroQol 5-dimensional 5-level questionnaire. Statistical differences between patients with and without fracture were tested with Pearson’s χ2 test, Student’s t-test, and the Mann–Whitney U-test. The association between HRQOL and other variables was evaluated using a multiple linear regression model. Results: The patients’ mean age±standard deviation was 67.3±11.9 years, and 74.1% were women. One hundred and seventeen (23%) patients had hip fractures, 56 (11%) had vertebral fractures, 127 (25%) had forearm fractures, and 178 (40%) had no fractures. The median (interquartile range) values of HRQOL scores of those with hip, vertebral, and forearm fractures and those with no history of fracture were 0.53 (0.22), 0.60 (0.28), 0.64 (0.26), and 0.64 (0.27), respectively. The multiple regression model revealed a significant relationship between the HRQOL scores and sex, marital status, employment status, presence of any chronic illness in addition to osteoporosis, and type of fracture. Conclusions: Osteoporosis and its related fractures can reduce the HRQOL.
참고문헌 (30)
- Lee YK, "Transcultural adaptation and psychometric properties of the Korean version of the Quality of Life Questionnaire of the European Foundation for Osteoporosis(QUALEFFO-41)", Arch Osteoporos, 14, pp.96~ (2019)[DOI]
- Pisani P, "Major osteoporotic fragility fractures : Risk factor updates and societal impact", World J Orthop, 7, pp.171~181 (2016)[DOI]
- Irani AD, "Prevalence of osteoporosis in Iran : A meta-analysis", J Res Med Sci, 18, pp.759~766 (2013)
- Fahimfar N, "Prevalence of osteoporosis among the elderly population of Iran", Arch Osteoporos, 16, pp.16~ (2021)[DOI]
- Porter JL, "StatPearls", pp.NBK441901~ (2022), StatPearls Publishing
- Cooper C, "Epidemiology of childhood fractures in Britain : a study using the general practice research database", J Bone Miner Res, 19, pp.1976~1981 (2004)[DOI]
- Tanha K, "Annual incidence of osteoporotic hip fractures in Iran : a systematic review and meta-analysis", BMC Geriatr, 21, pp.668~ (2021)[DOI]
- Varni JW, "The PedsQL 4.0 as a pediatric population health measure: feasibility, reliability, and validity", Ambul Pediatr, 3, pp.329~341 (2003)[DOI]
- Al-Sari UA, "Health-related quality of life in older people with osteoporotic vertebral fractures : a systematic review and meta-analysis", Osteoporos Int, 27, pp.2891~2900 (2016)[DOI]
- "EQ-5D-5L" (2017)[URL]
- Borgström F, "The International Costs and Utilities Related to Osteoporotic Fractures Study(ICUROS)-quality of life during the first 4 months after fracture", Osteoporos Int, 24, pp.811~823 (2013)[DOI]
- Cook DJ, "Quality of life issues in women with vertebral fractures due to osteoporosis", Arthritis Rheum, 36, pp.750~756 (1993)[DOI]
- Lips P, "Quality of life in patients with osteoporosis", Osteoporos Int, 16, pp.447~455 (2005)[DOI]
- Martin AR, "The impact of osteoporosis on quality-of-life : the OFELY cohort", Bone, 31, pp.32~36 (2002)[DOI]
- Ciubean AD, "Health-related quality of life in Romanian postmenopausal women with osteoporosis and fragility fractures", Clin Interv Aging, 13, pp.2465~2472 (2018)[DOI]
- Bianchi ML, "Quality of life in post-menopausal osteoporosis", Health Qual Life Outcomes, 3, pp.78~ (2005)[DOI]
- Wilson S, "Health-related quality of life in patients with osteoporosis in the absence of vertebral fracture : a systematic review", Osteoporos Int, 23, pp.2749~2768 (2012)[DOI]
- Goudarzi R, "Valuation of quality weights for EuroQol 5-dimensional health states with the time trade-off method in the capital of Iran", Value Health Reg Issues, 18, pp.170~175 (2019)[DOI]
- van Hout B, "Interim scoring for the EQ-5D-5L : mapping the EQ-5D-5L to EQ-5D-3L value sets", Value Health, 15, pp.708~715 (2012)[DOI]
- Lewiecki EM, "Osteoporotic fracture trends in a population of US managed care enrollees from 2007 to 2017", Osteoporos Int, 31, pp.1299~1304 (2020)[DOI]
- Dyer SM, "A critical review of the long-term disability outcomes following hip fracture", BMC Geriatr, 16, pp.158~ (2016)[DOI]
- Lesnyak O, "Quality of life after fragility fracture in the Russian Federation : results from the Russian arm of the International Cost and Utility Related to Osteoporotic Fractures Study(ICUROS)", Arch Osteoporos, 15, pp.37~ (2020)[DOI]
- Borgström F, "Costs and quality of life associated with osteoporosis-related fractures in Sweden", Osteoporos Int, 17, pp.637~650 (2006)[DOI]
- Amarilla-Donoso FJ, "Quality of life in elderly people after a hip fracture : a prospective study", Health Qual Life Outcomes, 18, pp.71~ (2020)[DOI]
- Adachi JD, "Impact of prevalent fractures on quality of life : baseline results from the global longitudinal study of osteoporosis in women", Mayo Clin Proc, 85, pp.806~813 (2010)[DOI]
- Hall SE, "A case-control study of quality of life and functional impairment in women with long-standing vertebral osteoporotic fracture", Osteoporos Int, 9, pp.508~515 (1999)[DOI]
- Hagino H, "Sequential change in quality of life for patients with incident clinical fractures : a prospective study", Osteoporos Int, 20, pp.695~702 (2009)[DOI]
- 권혜영, "Health-related Quality of Life in Accordance with Fracture History and Comorbidities in Korean Patients with Osteoporosis", 대한골대사학회지, 23(4), pp.199~206 (2016), 대한골대사학회[DOI]
- Emrani Z, "Health-related quality of life measured using the EQ-5D-5 L : population norms for the capital of Iran", Health Qual Life Outcomes, 18, pp.108~ (2020)[DOI]
- Brazier J, "A review of generic preference-based measures for use in cost-effectiveness models", Pharmacoeconomics, 35, pp.21~31 (2017)[DOI]