초기 녹내장에서 3D 스펙트럼영역 빛간섭단층촬영기와 시간영역 빛간섭단층촬영기의 진단력 비교
Comparison of Diagnostic Ability of 3D and Stratus Optical Coherence Tomography in Early Glaucoma
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목적: 초기녹내장에서 3D 스펙트럼영역 빛간섭단층촬영기(3D Optical Coherence Tomography [OCT])와 시간영역 빛간섭단층촬영기(Stratus OCT)의 진단력을 비교하였다. 대상과 방법: 정상 69안과 초기녹내장 48안을 대상으로 3D와 Stratus로 시신경유두와 망막신경섬유층의 두께 측정치들을 구하였다. 결과: 초기녹내장과 정상의 구별에 가장 유용한 Stratus 측정치들과 기준은 시신경유두 측정치들 중 horizontal integrated rim width (areas under receiver operating characteristics curve [AUC]=0.85), 망막신경섬유층 측정치들 중 하사분면(0.88), 기준들 중 정상치 5% 미만의 1시간 이상 비정상(0.81)이었고, 3D는 각각 수직유두함몰비(0.85), 11시 시구역 망막신경섬유층 두께(0.86), 정상치 1%미만의 1시간 이상 비정상(0.78)이었다. 두 기기 간에 상응하는 가장 유용한 측정치들과 기준의 AUC는 유의한 차이가 없었다(각각p=0.95, 0.73, 0.45). 결론: Stratus와 3D의 초기녹내장 진단력은 비슷하였다.
Abstract
Purpose: To compare the ability of three dimensional spectral-domain optical coherence tomography (3D OCT) and Stratus OCT to detect early glaucoma. Methods: The optic disc topographic and retinal nerve fiber layer (RNFL) thickness parameters were measured by 3D OCT and Stratus OCT in 69 normal eyes and 48 early glaucoma eyes. The discriminating abilities of the two techniques for detection of glaucoma were compared by the area under the receiver operating characteristic curves (AUC). Results: The best Stratus OCT parameters and criterion that differentiated normal from early glaucoma based on AUC were horizontal integrated rim width (0.85) for optic nerve head parameters, inferior quadrant (0.88) for RNFL parameters,and ≥1 clock-hour abnormal at the 5% level (0.81) based on the normative database for criteria. The best 3D OCT parameters and criterion that differentiated normal from early glaucoma were vertical cup-to-disc ratio (0.85), 11 o'clock RNFL thickness (0.86), and ≥1 clock-hour abnormal at the 1% level (0.78), respectively. When all corresponding the best parameters and criterion were compared, there were no significant differences between the AUCs for Stratus OCT and 3D OCT (p = 0.95, p = 0.73, p = 0.45, respectively). Conclusions: Stratus OCT and 3D OCT had similar diagnostic ability for detection of early glaucoma.
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