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젊은 연령에서 정상안압녹내장 환자의 각막생체역학인자

Corneal Biomechanical Properties of Normal Tension Glaucoma in Young Patients Evaluated with the Ocular Response Analyzer

최규룡|류진영
대한안과학회 (The Korean Ophthalmological Society)|2013.02|대한안과학회지 (Journal of The Korean Ophthalmological Society)|제54권 제2호|pp. 280-288

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키워드

YoungNormal tension glaucomaOcular Response Analyzer
주제분류안과학

초록

목적: 젊은 연령에서 진단된 정상안압녹내장 환자의 각막생체역학인자의 범위와 이에 영향을 미치는 인자를 알아보았다. 대상과 방법: 40세 미만의 정상군 42안, 정상안압녹내장군 37안을 대상으로 Ocular Response Analyzer (ORA)를 이용한 각막생체역학인자를 비교 분석하였다. 결과: 정상군과 정상안압녹내장군 두 군간의 중심각막두께는 유의한 차이가 없었다(p=0.52). 정상군과 정상안압녹내장군에서의 평균corneal hysteresis (CH)는 각각 10.9 ± 2.0 mmHg, 9.8 ± 1.8 mmHg이며, 평균 corneal resistance factor (CRF)는 10.7 ± 2.3mmHg, 9.2 ± 2.1 mmHg로 CH와 CRF 모두 정상안압녹내장군에서 유의하게 낮았다(p=0.01, p＜0.01). 다중회귀분석결과, CH과 CRF 는 중심각막두께 및 정상안압녹내장 여부에 유의한 상관관계를 보였다(p＜0.01, p＜0.01). 결론: 젊은 연령에서 진단된 정상안압녹내장 환자에서 Corneal compensated IOP (IOP cc)는 정상안과 유의한 차이를 보이지 않았으나, CH와 CRF는 유의하게 낮았다.

Abstract

Purpose: To evaluate the corneal biomechanical properties and clinical characteristic of normal tension glaucoma (NTG)in young patients. Methods: We compared corneal biomechanical properties using an Ocular response analyzer (ORA) of under age 40 of 37eyes of patients with NTG and 42 eyes of normal group. Results: The mean corneal resistance factor (CRF) and mean corneal hysteresis (CH) were significantly lower in NTG eyes (CRF, 9.2 ± 2.1 mm Hg; CH, 9.8 ± 1.8 mm Hg) than in normal eyes (CRF, 10.7 ± 2.3 mm Hg; CH, 10.9 ± 2.0 mm Hg;p = 0.01, p < 0.01). CH and CRF were associated with central corneal thickness (CCT) (CH; β = 0.354, p < 0.01, CRF; β= 0.348, p < 0.01) and glaucoma status (p < 0.01, p < 0.01). Conclusions: The CRF and CH were significantly lower in NTG group while IOP cc was not significantly different between the group. In diagnosing the NTG in young patients, ORA maybe useful for distinguishing between the glaucoma eyes and normal eyes.

참고문헌 (46)

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