건성안에서 비디오각막경검사 지표의 임상 유의성
Clinical Significance of Computerized Videokeratoscopic Indices for Dry Eye
0
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
목적: Tomey사의 TMS-4N™ 비디오각막경검사(Tomey, Nagoya, Japan)의 규칙성 지표들과 건성안의 기존 평가법들 및 건성안의 중증도와의 상관관계를 비교함으로써, 건성안 평가를 위한 비디오각막경검사의 가치를 알아보고자 하였다. 대상과 방법: 본 후향적 연구에서 총 193명(386안)의 건성안환자들의 의무기록을 분석하였다. TMS-4N™의 규칙성 지표들인 surface asymmetry index (SAI), surface regularity index (SRI), potential visual acuity (PVA), irregular astigmatism index (IAI)와 교정시력, Ocular Surface Disease Index (OSDI) score, 눈물막파괴시간, 각막염색점수, 쉬르머 I 검사 결과를 비교하고, 한국각막질환연구회 분류에 따른 건성안 중증도와의 상관관계를 분석하였다. 결과: 규칙성 지표들인 SAI, SRI, PVA, IAI는 건성안의 중증도에 따라 증가하였다. 규칙성 지표들은 교정시력, 각막염색점수와는 유의한 양의 상관관계, 눈물막파괴시간검사와는 유의한 음의 상관관계를 보였다. OSDI score는 규칙성 지표들과 유의한 상관관계를 보이지 않았다. 결론: TMS-4N™의 규칙성 지표들은 건성안의 중증도 평가와 경과 관찰의 객관적인 방법으로 사용될 수 있으리라 생각한다.
Abstract
Purpose: We evaluated the usefulness of the Tomey TMS-4N™ computerized videokeratoscopy (Tomey, Nagoya, Japan) for dry eye by analyzing the correlation between the regularity indices of TMS-4N™ and conventional dry eye parameters or dry eye severity. Methods: In this retrospective study, the medical records of 193 dry eye patients (386 eyes) were analyzed. The regularity indices of TMS-4N™ such as the surface asymmetry index (SAI), surface regularity index (SRI), potential visual acuity (PVA), and irregular astigmatism index (IAI) were compared with conventional dry eye parameters (corrected visual acuity [CVA], ocular surface disease index [OSDI] score, tear film break-up time [TBUT], corneal staining score [CFS], and Schirmer’s I test). We also analyzed correlations between the regularity indices of TMS-4N™ and dry eye severity according to the Korean Corneal Disease Study Group. Results: The regularity indices of TMS-4N™ such as SAI, SRI, PVA, and IAI increased according to the severity of dry eye. The regularity indices correlated significantly and positively with the CVA and CFS, but were significantly and negatively correlated with the TBUT. The OSDI score did not correlate with the regularity indices. Conclusions: The regularity indices of TMS-4N™ provide an objective method for follow-up as well as a means to measure the severity of dry eye disease.
참고문헌 (34)
- Craig JP, "TFOS DEWS II definition and classification report", Ocul Surf, 15, pp.276~283 (2017)
- Stapleton F, "TFOS DEWS II epidemiology report", Ocul Surf, 15, pp.334~365 (2017)
- Ahn JM, "Prevalence of and risk factors associated with dry eye : the Korea National Health and Nutrition Examination Survey 2010-2011", Am J Ophthalmol, 158, pp.1205~1214 (2014)
- Roh HC, "Systemic comorbidities of dry eye syndrome : the Korean National Health and Nutrition Examination Survey V, 2010 to 2012", Cornea, 35, pp.187~192 (2016)
- Paulsen AJ, "Dry eye in the beaver dam offspring study : prevalence, risk factors, and health-related quality of life", Am J Ophthalmol, 157, pp.799~806 (2014)
- Wolffsohn JS, "TFOS DEWS II diagnostic methodology report", Ocul Surf, 15, pp.539~574 (2017)
- Patel S, "Effects of fluorescein on tear breakup time and on tear thinning time", Am J Optom Physiol Opt, 62, pp.188~190 (1985)
- Mengher LS, "Effect of fluorescein instillation on the pre-corneal tear film stability", Curr Eye Res, 4, pp.9~12 (1985)
- Mengher LS, "A non-invasive instrument for clinical assessment of the pre-corneal tear film stability", Curr Eye Res, 4, pp.1~7 (1985)
- Nichols KK, "The repeatability of clinical measurements of dry eye", Cornea, 23, pp.272~285 (2004)
- Pinschmidt NW, "Evaluation of the Schirmer tear test", South Med J, 63, pp.1256~ (1970)
- Feldman F, "Evaluation of the Schirmer tear test", Can J Ophthalmol, 14, pp.257~259 (1979)
- Wright JC, "A review of the Schirmer test for tear production", Arch Ophthalmol, 67, pp.564~565 (1962)
- Lemp MA, "Report of the National Eye Institute", Industry workshop on Clinical Trials in Dry Eyes, 1995, pp.21, 221~232
- de Paiva CS, "Assessing the severity of keratitis sicca with videokeratoscopic indices", Ophthalmology, 110, pp.1102~1109 (2003)
- Ozkan Y, "Corneal topographical study of the effect of lacrimal punctum occlusion on corneal surface regularity in dry eye patients", Eur J Ophthalmol, 11, pp.116~119 (2001)
- Liu Z, "Corneal surface regularity and the effect of artificial tears in aqueous tear deficiency", Ophthalmology, 106, pp.939~943 (1999)
- 현준영, "Korean Guidelines for the Diagnosis and Management of Dry Eye: Development and Validation of Clinical Efficacy", Korean Journal of Ophthalmology, 28(3), pp.197~206 (2014), 대한안과학회
- McGinnigle S, "Evaluation of dry eye", Surv Ophthalmol, 57, pp.293~316 (2012)
- Yoon KC, "Usefulness of double vital staining with 1% fluorescein and 1% lissamine green in patients with dry eye syndrome", Cornea, 30, pp.972~976 (2011)
- Bron AJ, "Grading of corneal and conjunctival staining in the context of other dry eye tests", Cornea, 22, pp.640~650 (2003)
- 이석재, "연령에 따른 안구건조증의 3% 디쿠아포솔나트륨 점안 효능 비교", 대한안과학회지, 57(5), pp.734~741 (2016), 대한안과학회
- Tsubota K, "Tear dynamics and dry eye", Prog Retin Eye Res, 17, pp.565~596 (1998)
- Chen JJ, "Corneal epithelial opacity in dysfunctional tear syndrome", Am J Ophthalmol, 148, pp.376~382 (2009)
- 최계원, "건성안에서 인공누액 점안 후의 안구 수차의 변화 양상", 대한안과학회지, 47(2), pp.186~191 (2006), 대한안과학회
- Shiotani Y, "Comparison of topographic indices that correlate with visual acuity in videokeratography", Ophthalmology, 107, pp.559~564 (2000)
- Liu Z, "The effects of long-term contact lens wear on corneal thickness, and surface regularity", Ophthalmology, 107, pp.105~111 (2000)
- Dursun D, "The effects of experimental tear film removal on corneal surface regularity and barrier function", Ophthalmology, 107, pp.1754~1760 (2000)
- Németh J, "Corneal topography changes after a 15 second pause in blinking", J Cataract Refract Surg, 27, pp.589~592 (2001)
- Battat L, "Effects of laser in situ keratomileusis on tear production, clearance, and the ocular surface", Ophthalmology, 108, pp.1230~1235 (2001)
- Goto T, "Gender-and age-related differences in corneal topography", Cornea, 20, pp.270~276 (2001)
- Maeda N, "Prediction of letter contrast sensitivity using videokeratographic indices", Am J Ophthalmol, 129, pp.759~763 (2000)
- Schein OD, "Relation between signs and symptoms of dry eye in the elderly. A population-based perspective", Ophthalmology, 104, pp.1395~1401 (1997)
- Nichols KK, "The lack of association between signs and symptoms in patients with dry eye disease", Cornea, 23, pp.762~770 (2004)