Comparison of Automated Brain Volume Measures by NeuroQuant vs. Freesurfer in Patients with Mild Cognitive Impairment: Effect of Slice Thicknes
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Purpose: This study aimed to examine the inter-method reliability and volumetric differences between NeuroQuant (NQ) and Freesurfer (FS) using T1 volume imaging sequence with different slice thicknesses in patients with mild cognitive impairment (MCI). Materials and Methods: This retrospective study enrolled 80 patients diagnosed with MCI at our memory clinic. NQ and FS were used for volumetric analysis of three-dimensional T1-weighted images with slice thickness of 1 and 1.2 mm. Inter-method reliability was measured with Pearson correlation coefficient (r), intraclass correlation coefficient (ICC), and effect size (ES). Results: Overall, NQ volumes were larger than FS volumes in several locations: whole brain (0.78%), cortical gray matter (5.34%), and white matter (2.68%). Volume measures by NQ and FS showed good-to-excellent ICCs with both 1 and 1.2 mm slice thickness (ICC=0.75–0.97, ES=-1.0–0.73 vs. ICC=0.78–0.96, ES=-0.9–0.77, respectively), except for putamen, pallidum, thalamus, and total intracranial volumes. The ICCs in all locations, except the putamen and cerebellum, were slightly higher with a slice thickness of 1 mm compared to those of 1.2 mm. Conclusion: Inter-method reliability between NQ and FS was good-to-excellent in most regions with improvement with a 1-mm slice thickness. This finding indicates that the potential effects of slice thickness should be considered when performing volumetric measurements for cognitive impairment.
Abstract
Purpose: This study aimed to examine the inter-method reliability and volumetric differences between NeuroQuant (NQ) and Freesurfer (FS) using T1 volume imaging sequence with different slice thicknesses in patients with mild cognitive impairment (MCI). Materials and Methods: This retrospective study enrolled 80 patients diagnosed with MCI at our memory clinic. NQ and FS were used for volumetric analysis of three-dimensional T1-weighted images with slice thickness of 1 and 1.2 mm. Inter-method reliability was measured with Pearson correlation coefficient (r), intraclass correlation coefficient (ICC), and effect size (ES). Results: Overall, NQ volumes were larger than FS volumes in several locations: whole brain (0.78%), cortical gray matter (5.34%), and white matter (2.68%). Volume measures by NQ and FS showed good-to-excellent ICCs with both 1 and 1.2 mm slice thickness (ICC=0.75–0.97, ES=-1.0–0.73 vs. ICC=0.78–0.96, ES=-0.9–0.77, respectively), except for putamen, pallidum, thalamus, and total intracranial volumes. The ICCs in all locations, except the putamen and cerebellum, were slightly higher with a slice thickness of 1 mm compared to those of 1.2 mm. Conclusion: Inter-method reliability between NQ and FS was good-to-excellent in most regions with improvement with a 1-mm slice thickness. This finding indicates that the potential effects of slice thickness should be considered when performing volumetric measurements for cognitive impairment.
참고문헌 (27)
- Brewer JB, "Fully-automated quantification of regional brain volumes for improved detection of focal atrophy in Alzheimer disease", AJNR Am J Neuroradiol, 30, pp.578~580 (2009)
- Braak H, "Neuropathological stageing of Alzheimer-related changes", Acta Neuropathol, 82, pp.239~259 (1991)
- Jack CR Jr, "Medial temporal atrophy on MRI in normal aging and very mild Alzheimer’s disease", Neurology, 49, pp.786~794 (1997)
- 박미나, "Structural MR Imaging in the Diagnosis of Alzheimer’s Disease and Other Neurodegenerative Dementia: Current Imaging Approach and Future Perspectives", Korean Journal of Radiology, 17(6), pp.827~845 (2016), 대한영상의학회[DOI]
- Min J, "Diagnostic efficacy of structural MRI in patients with mild-to-moderate Alzheimer disease : automated volumetric assessment versus visual assessment", AJR Am J Roentgenol, 208, pp.617~623 (2017)
- Jenkinson M, "FSL", Neuroimage, 62, pp.782~790 (2012)
- Smith SM, "Advances in functional and structural MR image analysis and implementation as FSL", Neuroimage, 23(Suppl 1), pp.S208~S219 (2004)
- Ashburner J, "Voxel-based morphometry--the methods", Neuroimage, 11(6 Pt 1), pp.805~821 (2000)
- Fischl B, "FreeSurfer", Neuroimage, 62, pp.774~781 (2012)
- Brewer JB, "Fully-automated volumetric MRI with normative ranges : translation to clinical practice", Behav Neurol, 21, pp.21~28 (2009)
- Birk S, "Hippocampal atrophy : biomarker for early AD? Hippocampal volume in patients with AD is typically two standard deviations below normal", Internal Medicine News, 42, pp.12~ (2009)
- Kovacevic S, "High-throughput, fully automated volumetry for prediction of MMSE and CDR decline in mild cognitive impairment", Alzheimer Dis Assoc Disord, 23, pp.139~145 (2009)
- Ochs AL, "Comparison of automated brain volume measures obtained with NeuroQuant® and FreeSurfer", J Neuroimaging, 25, pp.721~727 (2015)
- Baker M, "Is there a reproducibility crisis? A Nature survey lifts the lid on how researchers view the’crisis rocking science and what they think will help", Nature, 533, pp.452~455 (2016)
- Ross DE, "High correlations between MRI brain volume measurements based on NeuroQuant® and FreeSurfer", Psychiatry Res Neuroimaging, 278, pp.69~76 (2018)
- Storelli L, "Measurement of whole-brain and gray matter atrophy in multiple sclerosis : assessment with MR imaging", Radiology, 288, pp.554~564 (2018)
- Fischl B, "Whole brain segmentation : automated labeling of neuroanatomical structures in the human brain", Neuron, 33, pp.341~355 (2002)
- Bigler ED, "Diffuse damage in pediatric traumatic brain injury : a comparison of automated versus operator-controlled quantification methods", Neuroimage, 50, pp.1017~1026 (2010)
- Petersen RC, "Mild cognitive impairment : clinical characterization and outcome", Arch Neurol, 56, pp.303~308 (1999)
- Ferreira D, "Multiple sclerosis patients lacking oligoclonal bands in the cerebrospinal fluid have less global and regional brain atrophy", J Neuroimmunol, 274, pp.149~154 (2014)
- Guo C, "Repeatability and reproducibility of FreeSurfer, FSL-SIENAX and SPM brain volumetric measurements and the effect of lesion filling in multiple sclerosis", Eur Radiol, 29, pp.1355~1364 (2019)
- Koo TK, "A guideline of selecting and reporting intraclass correlation coefficients for reliability research", J Chiropr Med, 15, pp.155~163 (2016)
- Cohen J, "Statistical power analysis for the behavioral sciences" (1988), Lawrence Erlbaum Associates
- Stein JL, "Identification of common variants associated with human hippocampal and intracranial volumes", Nat Genet, 44, pp.552~561 (2012)
- "NeuroQuant 3.0: scanner parameters"[URL]
- Olejnik S, "Measures of effect size for comparative studies : applications, interpretations, and limitations", Contemp Educ Psychol, 25, pp.241~286 (2000)
- Gronenschild EH, "The effects of FreeSurfer version, workstation type, and Macintosh operating system version on anatomical volume and cortical thickness measurements", PLoS One, 7, pp.e38234~ (2012)