저밀도 내피세포 환자의 백내장 수술 후 장기 임상결과
Long-Term Results after Cataract Surgery in Patients with Low Corneal Endothelial Cell Density
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초록
목적: 저밀도내피세포 환자에서 백내장수술 시행 후의 장기 임상결과를 알아보고자 하였다. 대상과 방법: 백내장 수술 전 각막내피의 세포밀도가 1,000개/mm2 이하였던 19명 19안을 저밀도내피세포군, 각막내피세포밀도가 정상이었던 경우를 대조군으로 설정하여 후향적 의무기록 분석을 시행하였고, 수술 전과 후 1주일, 1, 3, 6 그리고, 12개월째 시력, 안압,구면대응치, 전방 깊이, 안축장 길이, 중심각막두께 그리고, 각막내피세포밀도와 형태를 비교 분석하였다. 결과: 두 군 간 백내장 수술 후 시력, 안압, 구면대응치, 전방 깊이는 전 기간 동안 차이가 없었으나, 각막내피세포밀도의 감소율은수술 후 1주일째(p=0.02)와 1개월째(p=0.03), 중심각막두께는 수술 후 1주일째(p<0.01)와 1개월째(p=0.01) 유의한 차이를 보였고 수술후 3개월째부터 차이가 없었다. 각막내피세포밀도가 367개/mm2였던 1안에서만 수포각막병증이 발생하였다. 결론: 저밀도내피세포 환자의 백내장 수술은 수술 후 초기에는 정상군에 비해 각막내피세포밀도의 감소와 중심각막두께의 증가가 관찰되나 수술 후 3개월 이후부터는 유의한 차이가 없어 장기적으로 안전함을 알 수 있다.
Abstract
Purpose: To investigate the long-term results after cataract surgery in eyes with low endothelial cell density (ECD). Methods: A retrospective medical record review was performed of 19 patients with low ECD (lower than 1000 cells/mm2)who 31 patients with a normal ECD (higher than 1600 cells/mm2) underwent cataract surgery. Clinical parameters including visual acuity, intraocular pressure (IOP), spherical equivalent refraction, anterior chamber depth, axial length and central corneal thickness (CCT) were measured and specular microscopy was performed to analyze the ECD and its morphology. The follow-up periods were 1 week, and 1, 3, 6 and 12 months postoperatively. Results: Clinical parameters except ECD and CCT had no significant difference between the 2 groups until 12 months postoperatively. The decreasing rate of ECD and increase of CCT were significantly different between the 2 groups at 1 week and 1 month postoperatively. However, no significant difference was found after 3 months postoperatively. Only 1 eye in the low ECD group with 367 cells/mm2 developed bullous keratopathy. Conclusions: In the low ECD group, a significant decrease of ECD and increase of CCT were observed at 1 month after cataract surgery. However there were no significant differences compared with the control group after 3 months postoperatively. The results suggest that cataract surgery is safe postoperatively for a long-term for a patient with low ECD.
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