유수정체용 전방각지지렌즈 삽입 후 각막내피세포의 장기 변화
Long-Term Endothelial Cell Changes after Angle-Supported Anterior Chamber Lens Implantation in Phakic Eyes
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목적: 고도근시 교정을 위한 유수정체용 전방각지지렌즈(Phakic 6H) 삽입술 후 각막 내피세포의 장기 변화에 대하여 알아보고자 하였다. 대상과 방법: 유수정체용 전방각지지렌즈 삽입술을 시행한 55명, 110안을 대상으로 후향적으로 의무기록을 분석하였다. 수술 전 및 수술후 5년 이상의 추적관찰 기간 동안 각막내피세포밀도(cell density), 세포면적변이계수(polymegethism) 및 육각형세포율(pleomorphism)을 측정하였다. 결과: 각막내피세포밀도는 수술 전 평균 2951 ± 336 cells/mm2에 비하여 수술 후 평균 감소율은 1년에 3.8%, 3년에 12.6%, 5년에 13.4%,7년에 22.5%, 9년에 22.2%로 매년 통계적으로 의미 있는 각막 내피세포의 감소를 보였다. 13안(11.8%)에서는 각막내피세포밀도가 평균936 ± 458 cells/mm2으로 감소하여 렌즈를 제거하였다. 결론: 유수정체용 전방각지지렌즈(Phakic 6H) 삽입술 후 장기간 추적관찰 결과 지속적인 내피세포 소실을 관찰할 수 있었다. 이 수술을받은 환자들은 장기간의 추적관찰을 통한 지속적인 내피세포 평가가 필요하다고 생각한다.
Abstract
Purpose: To evaluate long-term endothelial cell changes in phakic eyes that underwent implantation of an angle-supported anterior chamber lens to correct myopia. Methods: A retrospective analysis was performed in 110 eyes of 55 patients who underwent implantation of angle-supported anterior chamber lenses with a follow-up period longer than 5 years. Comparisons were made between preoperative and postoperative endothelial cell density, coefficient of variation, and percentage of hexagonal cells. Results: Mean preoperative corneal endothelial cell density was 2951 ± 336 cells/mm2 and the percentage of cell loss was 3.8% at year 1, 12.6% at year 3, 13.4% at year 5, 22.5% at year 7, and 22.2% at year 9. Explantation was required in 13eyes (11.8%) due to the decrease of endothelial cell count to 936 ± 458 cells/mm2 over 9 years of follow-up. Conclusions: Continuous endothelial cell loss was observed after implantation of angle-supported anterior chamber lens in the long-term follow-up. A constant decline in the endothelial cell density necessitates periodic ophthalmologic evaluation including specular microscopy.
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